1/15. Ovarian fibrosarcoma producing multiple cytokines.A case of ovarian fibrosarcoma producing multiple cytokines is presented. The tumor occurred in the left ovary of a Japanese woman with epigastralgia, remittent fever, leukocytosis and slight thrombocytosis with moderate increase of mast cells in bone marrow, but lack of hormonal abnormality. The resected tumor of the ovary was well encapsulated and it was composed of spindle-shaped tumor cells and scattered tubules with marked mast cell infiltration. The tumor recurred in the pelvic cavity 14 months later, accompanied by similar signs and symptoms as occurred with the primary tumor. serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha were elevated. The recurrent tumor showed similar histological findings to those of the primary tumor, except for lack of tubules. Tumor cells revealed a focally positive immunoreaction for vimentin, IL-6 and TNF-alpha and alpha-inhibin. reverse transcription-polymerase chain reaction using total rna obtained from the recurrent tumor demonstrated mRNA expression of IL-6, IL-10, TNF-alpha and stem cell factor. This is a rare case of ovarian fibrosarcoma producing multiple cytokines, resulting in atypical clinical findings.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
2/15. Recurrent primary fibrosarcoma of the brain treated with the GliaSite brachytherapy system: case report.BACKGROUND: Primary brain sarcomas are rarely curable with surgery and standard radiation therapy. They typically recur locally within 6 months of treatment. This case report describes a novel treatment approach for primary or recurrent brain sarcomas with intracavitary brachytherapy. CASE DESCRIPTION: This 34-year-old female presented with a large and rapidly recurrent primary fibrosarcoma in the right fronto-parietal brain only 1 month postinitial total resection. She was reoperated, again with an MRI-documented gross total resection, but at this second surgery a GliaSite RTS (a recently FDA-approved balloon catheter system for intracranial intracavitary brachytherapy) was inserted into the surgical cavity. Over four days a radiation dose of 152 Gy was delivered at the balloon surface dose and 50.0Gy was delivered at a depth of 7 mm from balloon surface. The patient received subsequent treatment with external beam radiation and chemotherapy. The patient tolerated her treatment well and has shown no evidence of tumor recurrence with a follow up of 18 months. CONCLUSIONS: Boost intracavitary brachytherapy can play a critical role in preventing local recurrence and early death in patients with primary brain sarcomas.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
3/15. Inflammatory myofibroblastic tumor (inflammatory fibrosarcoma) of the pancreas: a case report.Inflammatory myofibroblastic tumors (inflammatory fibrosarcomas) of the pancreas are extremely rare. We report a 29-year-old woman who underwent pancreatoduodenectomy for a 6-cm tumor of the pancreas head causing obstructive jaundice. Tumor involvement was local, without apparent metastasis. The tumor was composed of proliferating fibroblastic/or myofibroblast-like spindle cells and aggregates of chronic inflammatory cells in a fibromyxoid matrix. Immunohistochemical examination demonstrated reactivity only to vimentin. This tumor has often been found in the peritoneal cavity, the retroperitoneum, or the pelvic cavity, but only very rarely in the pancreas.- - - - - - - - - - ranking = 2keywords = cavity (Clic here for more details about this article) |
4/15. fibrosarcoma originating in the mandible.fibrosarcoma is a malignant mesenchymal neoplasm of fibroblasts that rarely affects the oral cavity and can cause local recurrences or metastasis. In this article we describe a case of primary fibrosarcoma in the mandible in a 16-year-old girl. Microscopically the tumor showed an intense proliferation of spindle-shaped cells, varying little in size and shape and arranged in parallel bands, partly crossing each other, the mitotic activity was increased and there was nuclear pleomorphism. Immunohistochemically the cells only showed immunoreactivity for vimentin and negativity for S-100 protein, CD 68, cytokeratin cocktail, HMB-45, CD34, pan actin HHF 35, desmin, smooth muscle actin and epithelial membrane antigen (EMA). Based on clinical, radiological, histological and immunohistochemical findings the final diagnosis was high-grade intra-osseous fibrosarcoma. The treatment choice was radical surgery with mandibular reconstruction. After one year and nine months of the treatment the patient displayed multiple metastases. radiation therapy and chemotherapy were used as adjuvant treatment. Unfortunately, the girl died two years after initial diagnosis.- - - - - - - - - - ranking = 8.1267503240419keywords = oral cavity, cavity (Clic here for more details about this article) |
5/15. Fibrous tissue tumours.Thirty-three patients, ranging in age from newborn to 12 years, with fibrous tissue tumours, were treated at the Hospital for Sick Children, Great Ormond Street, london, from 1970 to 1984. Seven infants presented with tumours at birth. In 42% of cases, the tumour was noted during the 1st year of life. The anatomical distribution of the lesions was: upper extremity 6, lower extremity 5, head and neck 10, trunk 6, thoracic cavity 2 (heart 1), abdominal cavity 4 (pelvis, bladder, small bowel mesentery, and canal). Three patients had multiple tumours. Seven of the tumours were classified as sarcomas. Complete excision was possible in 28 patients, following initial biopsy in six patients of whom three were treated preoperatively with radiotherapy and/or chemotherapy. There were two deaths, one in an infant with a huge resectable pelvic tumour and the other in a child with cardiac fibroma. Recurrences occurred in 14 patients (48%), in nine of whom the recurrences were multiple. The mean time interval to recurrence was 13.8 months.- - - - - - - - - - ranking = 2keywords = cavity (Clic here for more details about this article) |
6/15. fibrosarcoma of the mandible.fibrosarcoma is a rare malignancy in the oral cavity. Tumours of fibrous connective tissue are sometimes difficult to classify as benign or malignant. The literature is reviewed and three cases of oral fibrosarcoma are presented.- - - - - - - - - - ranking = 8.1267503240419keywords = oral cavity, cavity (Clic here for more details about this article) |
7/15. Poorly differentiated fibrosarcoma (spindle cell sarcoma) involving the temporal bone.A case of metastatic fibrosarcoma of the temporal bone was studied histopathologically. The primary site of this tumor was the posterior neck region. The initial major symptom of the patient was a left facial nerve paralysis. Although the patient underwent a suboccipital posterior craniectomy, radio-, and chemotherapy, she eventually died from multiple metastases. Histological examination of the temporal bones showed an extensive tumor invasion in the external auditory canal, middle ear cavity, middle ear muscle, tympanic membrane, mastoid cavity, petrous apex, facial nerve, and superior division (distal segment) of the vestibular nerve (left ear). The route from the stylomastoid foramen to the superior division of the vestibular nerve via the facial nerve canal could be one of the possible passages of tumor invasion.- - - - - - - - - - ranking = 2keywords = cavity (Clic here for more details about this article) |
8/15. Sarcoma obstructing right ventricular cavity: clinical, echocardiographic, haemodynamic and angiographic features.Right atrial hypertension and pericardial effusion developed 2 years after mastectomy for fibrosarcoma. Clinical and echocardiographic features suggested right ventricular tumour. At catheterization the right ventricular cavity was almost obliterated, with an infundibular gradient of 13 mmHg, and biopsy of the mass was attempted. Post-mortem revealed extensive infiltrating and intracavitary right ventricular fibrosarcoma without extracardiac tumour.- - - - - - - - - - ranking = 5keywords = cavity (Clic here for more details about this article) |
9/15. Myofibroblastoma: a tumour of myofibroblasts.A myofibroblastoma occurring in the abdominal cavity of a 15 year old boy is described. This tumour was diagnosed as a low grade sarcoma by light microscopy but electron microscopy showed that the tumour was composed almost entirely of myofibroblasts and a few macrophages. Intermediate forms between myofibroblasts and macrophages were not seen nor were any fibroblasts seen in the main tumour mass. Total excision was impossible because the tumour had trapped loops of bowel and was adherent to the abdominal organs. The patient died of cachexia and haemorrhage but there were no distant metastases nor was there any marked infiltration of the abdominal organs. This case and a review of the literature shows that myofibroblastomas are locally aggressive tumours which do not metastasize and that if total excision is possible an uneventful recovery can be expected.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
10/15. Vascularized free fibula transfer in the treatment of bone tumours. Report of three cases.The surgical treatment of two cases of bone tumours and one case of a tumour-like lesion are reported in this article. The tumours were resected radically and the massive bone defect or bone cavity were substituted by vascularized free fibula transfer. All of them were cured by early union. Neither atrophy nor non-union between the graft and the recipient bone occurred. Early restoration of function was observed. Our experiences of isolating the graft and the operative procedure are discussed. We believe that this method has prospects not only in the field of treatment of bone tumours but also in the management of bone defects or non-union due to various other causes.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
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