1/13. Subsequent cancer in patients with Ewing's sarcoma.Among 31 long-term survivors of Ewing's sarcoma, two patients developed second primary cancers, compared to an expected number of 0.03 (relative risk = 72; 95% confidence limit = 8-259). One patient had renal medullary neuroblastoma, which is not known to be related to Ewing's tumor or its therapy. The second patient had a bone fibrosarcoma, arising at the primary tumor site, which was thought to be radiation-induced. The risk of radiation-induced bone sarcomas was lower, although not significantly so, than in a recently reported series of Ewing's tumor. These two reports suggest that patients with Ewing's sarcoma have a tendency to develop radiogenic sarcomas following primary megavoltage radiation therapy. The lowest radiation dose consistent with local tumor eradication should be employed to minimize the risk of subsequent radiogenic cancer.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
2/13. Echocardiographic assessment of radiation-induced mitral valve disease in a child.A young girl, previously treated with mediastinum irradiation because of a pulmonary fibrosarcoma, developed mitral valve disease with valvular insufficiency. In consideration of the clinical course and the echocardiographic findings, authors hypothesize a relation between the radiation therapy and the valvular damage.- - - - - - - - - - ranking = 2keywords = radiation-induced (Clic here for more details about this article) |
3/13. Unusual postirradiation sarcoma of chest wall.This paper reports a sarcoma of the chest wall following postoperative radiation therapy for breast carcinoma. A total of 9346 rads was delivered at a 2-cm tissue depth from two treatment courses separated by a five-year interval. The sarcoma appeared 16 years following the initial radiation course. The existence of two mesenchymal elements in the lesion led to the final diagnosis of malignant mesenchymoma. Criteria for evaluating a possible radiation-induced malignancy are discussed.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
4/13. radiation-induced fibrosarcoma following treatment for breast cancer.A patient with radiation-induced fibrosarcoma following mastectomy and postoperative radiation for bilateral breast carcinoma is described. Only six such cases have been reported in the literature. In this patient erosion of the axillary artery produced massive hemorrhage, and emergency transthoracic ligation of the subclavian artery caused gangrene of the extremity and empyema and sepsis. Interscapulothoracic amputation not only was life-saving but offered the patient a reasonable chance for long-term survival. Only aggressive surgical management can salvage a patient with radiation-induced sarcoma.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
5/13. fibrosarcoma of the mandible following supravoltage irradiation. Report of a case.Supravoltage irradiation is commonly thought not to be carcinogenic. Several recent studies question this concept, as does our case report. A 50-year-old woman with stage 1 squamous carcinoma of the left side of the tongue was treated in 1973 with 73 Gy of supravoltage irradiation. Twelve years later a painful, ulcerated lesion that eventually was shown to be fibrosarcoma developed in the contralateral mandible. The fibrosarcoma in this case fulfills all criteria for diagnosing radiation-induced neoplasia and demonstrates that supravoltage irradiation, like other forms of irradiation, can cause malignancy. The occasional occurrence of sarcoma should be recalled during follow-up of patients treated with supravoltage radiation. Similarly, the possibility of radiation-induced tumors should be considered in planning treatment for younger patients with tumors that can be treated equally well by surgery or irradiation.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
6/13. Postradiation sarcoma of bone in hodgkin disease.We report 16 cases seen in the Memorial Sloan-Kettering Cancer Center (MSKCC) during the past 50 years. These patients had been treated with external radiation for hodgkin disease and had developed sarcomas in the field 4-31 years after the diagnosis of hodgkin disease. Most of the tumors (12 of 16) occurred in the chest wall. There were three tumors of the pelvis and an unusual osteosarcoma of the femur following treatment for a primary hodgkin disease of the femur. The tumors were predominantly osteosarcomas (9). In addition, there were five malignant fibrous histiocytomas, one fibrosarcoma, and one chondrosarcoma. prognosis was poor; the mean survival was 12 months. survival of patients with other primary cancers who developed radiation sarcomas was not significantly different from that of patients with hodgkin disease. hodgkin disease is now the most common tumor among radiation-induced sarcomas in previously normal bone and has surpassed breast cancer, which was previously the most common original tumor.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
7/13. radiation-induced fibrosarcoma of the thyroid.A rare thyroid tumour is described. It started as a papillary cytoadenoma 20 years ago, followed by the appearance of a papillary adenocarcinoma 6 years later. At that time most of the tumour was excised, except for a small portion which had invaded the trachea. Post-operatively 6,000 rads of Co60 was given to the neck; the tumour remained quiescent for 18 years until two years ago, when a recurring fibrosarcoma appeared in her neck. It is suggested that this tumour was a radiation-induced sarcoma.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
8/13. fibrosarcoma in a previously irradiated larynx.The patient presented in this report had a rare tumour occurring in a situation suggestive of a radiation-induced mesenchymal neoplasm. attention is drawn to the need for prolonged follow-up in cases of squamous carcinomata of the larynx apparently disease free for many years following irradiation.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
9/13. Modified technique for radical transmediastinal forequarter amputation and chest wall resection.Forequarter or interscapulothoracic amputation is a major surgical procedure indicated primarily in the treatment of malignant lesions involving the bony and soft tissue parieties of the upper part of the arm, shoulder, and scapula. It is also indicated in extensive trauma with irreparable damage to the shoulder area and as a palliative measure in intractable pain caused by incurable tumors of the shoulder girdle. Several operative techniques have been described: the classical Berger approach, an anterior pectoral approach, and posterior retroscapular approaches. A radical transthoracic approach has been described in cases in which the tumor had spread through the chest wall. The two main goals of these approaches have been early ligation of the subclavian vessels and immediate exploration for operability. This report details our experience with a modified technique for radical forequarter amputation and chest wall resection in which a transmediastinal approach is employed. This approach was used in two patients: One had a radiation-induced fibrosarcoma of the left axilla and adjacent chest wall following a radical mastectomy 19 years earlier, and the other patient had a recurrent rhabdomyosarcoma of the right axilla with invasion of the chest wall. This technique avoids time-consuming and individual excision of ribs and minimizes the amount of blood loss by early ligation of the internal mammary vessels. Safe and excellent exposure and division of the subclavian vessels and early exploration for mediastinal and intrathoracic involvement are made possible. Details of the procedure with illustrations are described.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
10/13. radiation-induced fibrosarcoma of the head and neck.Primary fibrosarcoma of the neck is uncommon; radiation-induced similar lesions are rare. They might start as irradiation fibromatosis akin to extraabdominal desmoids, but they tend to kill by local invasion rather than by distant dissemination. The literature has been briefly reviewed with a short discussion of clinical and pathological features of both the primary (de novo) and the secondary (radiation-induced) types of fibrosarcoma. Two cases of post-irradiation fibrosarcoma of the neck are presented.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
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