1/12. Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma.adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of four adamantinomas, and a review of eleven cases in the literature reveals extra copies of chromosomes 7, 8, 12, 19, and 21 as recurrent in this neoplasm. adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma.- - - - - - - - - - ranking = 1keywords = adamantinoma (Clic here for more details about this article) |
2/12. Osteofibrous dysplasia: two affected male sibs and an unrelated girl with bilateral involvement.Osteofibrous dysplasia (OFD) is a tumor-like bone lesion that occurs most often in the tibia, presenting as a painless swelling or anterior bowing. Radiographs show a well-circumscribed intracortical lucency, or multiple lucencies separated by sclerotic borders, associated with a diaphyseal expansion. The histogenesis of OFD and its possible relationships to fibrous dysplasia and to adamantinoma have been the subject of significant discussion and investigation. We have been unable to find any reports of familial OFD, and have found only two references to bilateral involvement. In this article, we report both bilateral and familial involvement, and suggest that more thorough investigation of patients and their families may uncover similar cases, and perhaps support a genetic component to the etiology of this condition.- - - - - - - - - - ranking = 0.14285714285714keywords = adamantinoma (Clic here for more details about this article) |
3/12. Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst.adamantinoma, a rare bone lesion of the tibia and fibula, has two distinct variants, classic adamantinoma and osteofibrous dysplasia-like adamantinoma. Composite lesions have not been described. Aneurysmal bone cyst is a benign cystic lesion which may also occur in the tibia and fibula. We report an unusual case of classic adamantinoma with osteofibrous dysplasia-like areas and foci of secondary aneurysmal bone cyst with prominent giant cells. A lesion was diagnosed in a 17-year-old girl with a 14-year history of a slowly enlarging left tibial mass and increasing deformity. Pathologically, the predominant pattern was classic adamantinoma, with minor foci of osteofibrous dysplasia-like adamantinoma and areas of secondary aneurysmal bone cyst with abundant multinucleated giant cells. We report the clinical, radiologic, and pathologic features of this case, and summarize lesions associated with secondary aneurysmal bone cyst. To our knowledge, the association of adamantinoma with secondary aneurysmal bone cyst has not been previously reported.- - - - - - - - - - ranking = 1.4285714285714keywords = adamantinoma (Clic here for more details about this article) |
4/12. Osteofibrous dysplasia: a review of the literature and presentation of an additional 3 cases.Osteofibrous dysplasia is a rare fibro-osseous lesion of uncertain etiology that occurs exclusively in the pediatric population. diagnosis and treatment are complicated by the fact that osteofibrous dysplasia can resemble monostotic fibrous dysplasia and adamantinoma of long bones grossly and microscopically and that it tends to recur if surgical intervention is performed before skeletal maturity is reached. We present 3 cases of this lesion seen at our institution and provide a review of all previous cases reported in the literature.- - - - - - - - - - ranking = 0.14285714285714keywords = adamantinoma (Clic here for more details about this article) |
5/12. Juvenile intracortical adamantinoma of the tibia with predominant osteofibrous dysplasia-like features.In view of the still disputed relationship between adult adamantinoma and osteofibrous dysplasia in children, a unique case of adamantinoma, indicating a direct relationship between the two lesions, is presented with a review of the literature. The patient was a six-year-old boy who complained of pain and swelling in the left lower leg. Roentgenographs showed a loculate osteolysis surrounded by sclerosis within the cortex of the tibial shaft that would be typical of osteofibrous dysplasia. Although an osteofibrous-dysplastic component predominated histologically, some small islands of epithelial cells were scattered throughout the lesion. Immunohistochemically, the tumor cells of these epithelial islands gave a constant positive reaction for cytokeratin as well as vimentin, while the stromal cells in the osteofibrous dysplasia-like lesion were positive for vimentin only. This type of lesion is recorded in the Bone Tumor Registry of Westphalia at a rate of 8.3% for osteofibrous dysplasia, and of 25% for adamantinoma. A review of the literature, yielding reports with remarkable uniformity on 14 cases beyond the present one, suggests the existence of a separate clinicopathologic entity to be called juvenile intracortical adamantinoma with predominant osteofibrous dysplasia-like features, and which might be a regressing form of adamantinoma specific in childhood.- - - - - - - - - - ranking = 1.2857142857143keywords = adamantinoma (Clic here for more details about this article) |
6/12. Case report 587: adamantinoma of the tibia mimicking osteofibrous dysplasia.This case emphasized that the differential diagnosis of osteofibrous dysplasia and adamantinoma of the tibia can be difficult on roentgengrams as well as on histological studies. A radiological and histological diagnosis of osteofibrous dysplasia of the tibia in a young adult should always raise the consideration of the possibility of an adamantinoma, and in the correlation of the radiological features with the biopsy findings it is very important to gain representative tissue material for establishing the correct diagnosis of adamantinoma.- - - - - - - - - - ranking = 0.42857142857143keywords = adamantinoma (Clic here for more details about this article) |
7/12. adamantinoma of the tibia masked by fibrous dysplasia. Report of three cases.Three cases of adamantinoma of the tibia associated with and mimicking fibrous dysplasia or osteofibrous dysplasia are reported in children aged three, nine, and 16 years. The roentgenographic features were typical of intracortical fibrous dysplasia (osteofibrous dysplasia). These entities are not two distinct diseases, but rather are different histologic expressions of essentially the same process, which varies depending on location (predominantly intracortical or medullary) and age. adamantinoma in children under ten years of age is not as rare as reported in the literature and was found in two of 14 cases in our files (14.3%). In some cases the fibrous dysplasialike component predominates over the scarce epithelioid islands of tumor cells and consequently is not recognized as adamantinoma. That may explain the frequent recurrences after incomplete excisions of supposed intracortical fibrous dysplasia lesions in young children. An extensive histopathologic study of the biopsy and/or surgical specimen by a specialized pathologist is therefore advisable.- - - - - - - - - - ranking = 0.28571428571429keywords = adamantinoma (Clic here for more details about this article) |
8/12. adamantinoma associated with fibrous dysplasia.Three cases of adamantinoma of the tibia, seen in one hospital over a period of 7 years, are described. They illustrate the difficulty in differentiating this lesion from fibrous dysplasia on radiographic and histological grounds. thermography may help in the differential diagnosis.- - - - - - - - - - ranking = 0.14285714285714keywords = adamantinoma (Clic here for more details about this article) |
9/12. Ossifying fibroma of long bone: its distinction from fibrous dysplasia and its association with adamantinoma of long bone.Two cases of ossifying fibroma of long bones are presented. This tumor is confused with monostotic fibrous dysplasia, but can be distinguished by its intracortical location, as demonstrated radiographically, and by its histologic pattern. Distinction from fibrous dysplasia is important since ossifying fibroma of long bone is a more aggressive lesion with different therapeutic implications. It appears that ossifying fibroma and adamantinoma of long bones are somehow related, and that lesions resembling fibrous dysplasia in association with adamantinomas of long bones are actually ossifying fibromas.- - - - - - - - - - ranking = 0.85714285714286keywords = adamantinoma (Clic here for more details about this article) |
10/12. adamantinoma of the appendicular skeleton in children.The 260 cases of adamantinoma described in the world literature have been reviewed. Case histories of 60 patients up to the age of 16 years mirror those of adults. The mortality rate is 20% in children and adults. Wide excision with bone grafting is the ideal treatment for patients under 16 years.- - - - - - - - - - ranking = 0.14285714285714keywords = adamantinoma (Clic here for more details about this article) |
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