1/16. Interferon gamma (IFN-gamma) deficiency in generalized Epstein-Barr virus infection with interstitial lymphoid and granulomatous pneumonia, focal cerebral lesions, and genital ulcers: remission following IFN-gamma substitution therapy.A 26-year-old previously healthy woman developed granulomatous pneumonitis, encephalitis, and genital ulceration during primary Epstein-Barr virus (EBV) infection. EBV dna was demonstrated by polymerase chain reaction analysis of serum, lung tissue, and genital ulcer specimens. serology verified primary EBV infection. The patient lacked lymphocytes cytotoxic to autologous EBV-transformed B lymphocytes. No spontaneous or in vitro EBV-induced interferon gamma (IFN-gamma) production was evident in peripheral blood. The cells had normal IFN-gamma production when stimulated with staphylococcus aureus exotoxin A. In the bone marrow and peripheral blood, the number of large granular CD56 lymphocytes (natural killer cells) increased 39%-55%, but no CD4 or CD8 cell lymphocytosis was initially found. A partial clinical response was achieved with treatment with acyclovir, corticosteroids, and intravenous gamma-globulin. Because of persistent granulomatous central nervous system and lung involvement, subcutaneous IFN-gamma therapy was started but was discontinued after 3 months because of development of fever, pancytopenia, and hepatitis. This therapy initiated a complete clinical recovery, which occurred parallel to development of EBV-specific cytotoxic CD8 T lymphocytes and normalization of natural killer cell lymphocytosis. These findings provide evidence for an EBV-induced lymphoproliferative disorder due to a T lymphocyte dysfunction associated with a selective lack of IFN-gamma synthesis.- - - - - - - - - - ranking = 1keywords = granuloma (Clic here for more details about this article) |
2/16. malacoplakia of the ovary, fallopian tube and uterus: a case associated with diabetes mellitus.malacoplakia is a chronic xanthogranulomatous inflammation that most commonly affects the urinary tract and the gastrointestinal system of middle-aged women. It is rarely encountered in a female genital tract, and only a handful of cases of malacoplakia of the ovary have been described. We report an unusual case of malacoplakia extensively involving the ovary, fallopian tube and uterus of a 47-year-old woman with poorly controlled diabetes mellitus. escherichia coli was cultured from the ovarian lesion. To our knowledge, such an extensive female genital malacoplakia associated with diabetes mellitus has not been reported before. Widespread or atypical site malacoplakia occurring in a patient with systemic disease may result from a diminution of macrophagocytic function, either under the influence of the systemic illness or related to corticosteroid excess. We propose that diabetes mellitus without appropriate medical control may have resulted in impaired leukocyte function which, when combined with E. coli infection, led to the development of extensive malacoplakia in the genital tract of this patient.- - - - - - - - - - ranking = 0.16666666666667keywords = granuloma (Clic here for more details about this article) |
3/16. Ano-genital granulomatosis: the counterpart of oro-facial granulomatosis.Ano-genital granulomatosis encompasses the previously recognized clinical entities of vulvitis granulomatosa, posthitis granulomatosa, and ano-perineitis granulomatosa. We report three patients with ano-genital granulomatosis. The pathological features of the disease are lymphoedema and the presence of non-caseating giant cell granulomas. These granulomas are histologically indistinguishable from those found in both Crohn's disease and sarcoidosis, therefore, patients with ano-genital granulomatosis with accompanying gastro-intestinal or pulmonary symptoms should be investigated for the presence of Crohn's disease or sarcoidosis, respectively. The value of ano-genital granulomatosis as a unifying clinicopathologic concept is to provide a label for the affliction as well as to stimulate a careful search for possibly underlying systemic disorders, thus also permitting a more specific approach to therapy.- - - - - - - - - - ranking = 2.8333333333333keywords = granuloma (Clic here for more details about this article) |
4/16. blood-tinged stools and blood-shot eyes.A 37-year-old woman developed red painful eyes, diarrhea, and painful oral and genital ulcerations. optic disk swelling was noted bilaterally. colonoscopy was significant for granulomatous lesions consistent with crohn disease. epidemiologic factors, diagnostic criteria, and differentiating characteristics for Behcet disease and crohn disease are discussed.- - - - - - - - - - ranking = 0.16666666666667keywords = granuloma (Clic here for more details about this article) |
5/16. sarcoidosis of the female genital tract: a case presentation and survey of the world literature.sarcoidosis of the female genital tract is a rare clinical entity with only 20 cases reported in the world literature to date. An additional case is presented with a review of the previously reported cases. The diagnostic and histologic aspects of the disease are also discussed. The presence of granulomatous diseases in the female genital tract should initiate a thorough investigation for potential etiologies by both the pathologist and clinician. Etiologies of granuloma fraction must include coccidiomycosis, foreign body reactions, lymphogranuloma inguinale, and tuberculosis. Bacteriologic proof is essential to differentiate these from sarcoidosis.- - - - - - - - - - ranking = 54.619643449913keywords = inguinale, granuloma (Clic here for more details about this article) |
6/16. Xanthogranulomatous inflammation of the female genital tract.We describe three cases of xanthogranulomatous inflammation in the female genital tract--one affecting endometrium, tube and ovary, one affecting tube, ovary and parametrium and one confined to the endometrium. To date, xanthogranulomatous inflammation in the female genital tract has been reported in a total of 19 cases including the present three. The inflammation most often affects the endometrium but involvement of the vagina, cervix, fallopian tube and ovary may also occur.- - - - - - - - - - ranking = 1keywords = granuloma (Clic here for more details about this article) |
7/16. Pinworm infestation of the genital tract.Extraintestinal enterobiasis has been reported in the vagina, endometrium, myometrium, ovary, fallopian tube and pelvic peritoneum. Gravid female pinworms may migrate from the perianal area to the vagina, ascend through the genital tract and exit through the fallopian tube to the peritoneum. Ectopic enterobiasis seldom causes clinical symptoms, but chronic granuloma formation may simulate other mass lesions in the pelvis.- - - - - - - - - - ranking = 0.16666666666667keywords = granuloma (Clic here for more details about this article) |
8/16. coccidioidomycosis of the female genital tract.female genital tract involvement is a rare manifestation of disseminated coccidioidomycosis; to our knowledge, only ten patients have previously been described in the English literature. We describe a patient who seems to be unique in that she developed female genital tract coccidioidomycosis and coccidioidal peritonitis after chemotherapy for Hodgkin's disease. coccidioidomycosis of the female genital tract is usually manifest as granulomatous endometritis and/or granulomatous tubo-ovarian disease with peritonitis. The diagnosis of coccidioidomycosis was unsuspected clinically in all 11 reported cases (including our patient); initial diagnosis was made by biopsy or culture in all 11 patients. In eight of the reported cases of female genital tract coccidioidomycosis (including our patient), clinical improvement occurred after treatment with surgery or antifungal chemotherapy; three patients died of disseminated coccidioidomycosis.- - - - - - - - - - ranking = 0.33333333333333keywords = granuloma (Clic here for more details about this article) |
9/16. Malakoplakia of the female genital tract.A rare case of malakoplakia of the uterine cervix and the pelvis occurring in an elderly woman who also had xanthogranulomatous pyelonephritis is described and compared with the 15 reported cases of malakoplakia of the female genital tract.- - - - - - - - - - ranking = 0.16666666666667keywords = granuloma (Clic here for more details about this article) |
10/16. Schistosomal genital granulomas: a report of 10 cases.Genital lesions caused by schistosoma spp are difficult to diagnose because of their similarity to those of common sexually transmitted diseases (STD). Over two years 10 cases of genital lesions were identified by skin or cervical biopsies as being caused by schistosomal infection. Definitive diagnosis is possible only when schistosomal ova are identified by histological examination of biopsy specimens. Routine biopsies of proliferative genital lesions are therefore recommended in regions where schistosoma spp are endemic.- - - - - - - - - - ranking = 0.66666666666667keywords = granuloma (Clic here for more details about this article) |
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