1/5. Fatal Blastoschizomyces capitatus sepsis in a neutropenic patient with acute myeloid leukemia: first documented case from greece.Blastoschizomyces capitatus (formerly known as geotrichum capitatum and trichosporon capitatum) is a rare, yet an emerging, cause of invasive infections in immunosuppressed patients. Profound and prolonged neutropenia is the crucial predisposing factor for this yeast infection. Blastoschizomyces capitatus was isolated from peripheral blood cultures of a profoundly neutropenic patient with acute myeloid leukemia (M2 FAB). Despite administration of antifungal chemotherapy with liposomal amphotericin b at 4.5 mg kg(-1) daily, the patient succumbed 4 days after initiation of treatment. Infections attributed to B. capitatus have generally a poor prognosis, although the yeast shows in vitro susceptibility to antifungal agents. Low flucytosine, caspofungin acetate, voriconazole and amphotericin b minimum inhibitory concentration values were also recorded with our isolate. The clinical relevance of the in vitro susceptibility testing against the isolate and the current antifungal chemotherapy regimens against B. capitatus systemic infections are discussed.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
2/5. Disseminated geotrichum capitatum infection in a patient with acute myeloid leukemia.A case of invasive geotrichum capitatum infection is reported; a young patient had an acute leukemia for which he received a chemotherapy, and presented sepsis with blood cultures for geotrichum capitatum, namely dipodascus spicifer; this pathogen only described in cactus rot, is responsible for the first case of a human disseminated infection reported in literature. Then he developed a splenic and epididymic infection, with positive cultures for geotrichum capitatum after splenectomy and castration. Treatment with amphotericin b and itraconazole was started with low minimal inhibitory concentration (0.1 microgram/ml). The patient died of massive hemoptisis. autopsy findings demonstrated a lung, brain and kidneys seeding.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
3/5. Gastrointestinal phycomycosis in acute nonlymphatic leukemia.A 37-year-old patient with acute nonlymphatic leukemia developed gastrointestinal phycomycosis during failure in bone marrow production. The clinical presentation was of acute typhlitis. laparotomy revealed a necrotic mass in the region of the iliocecal valve, and on histologic examination hyphae of phycomycetes with invasion of the blood vessels were seen. The patient died as a result of widespread infection.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
4/5. Disseminated geotrichum candidum infection.The pathogenicity of the fungus geotrichum candidum in humans has not been clearly defined. A patient with acute leukemia who developed a fatal disseminated G. candidum infection while neutropenic is described. At autopsy examination, this patient was misdiagnosed on the basis of histopathology as having disseminated candidiasis until G. candidum was isolated from postmortem culture specimens. The emergence of this organism as an occasional pathogen in leukemic patients is of interest and illustrates the importance of obtaining fungal cultures. There is a need for more effective drugs for antifungal prophylaxis and therapy.- - - - - - - - - - ranking = 0.2keywords = leukemia (Clic here for more details about this article) |
5/5. osteomyelitis and intervertebral discitis caused by Blastoschizomyces capitatus in a patient with acute leukemia.We describe the first known case of vertebral osteomyelitis and discitis caused by Blastoschizomyces capitatus in a leukemic patient and the results of therapy. We also reconfirm the microbiological characteristics which differentiate this species from other yeastlike pathogens.- - - - - - - - - - ranking = 0.8keywords = leukemia (Clic here for more details about this article) |