1/9. Leukocyte adhesion deficiency in a child with severe oral involvement.Leukocyte adhesion deficiency is a rare inherited defect of phagocytic function resulting from a lack of leukocyte cell surface expression of beta2 integrin molecules (CD11 and CD18) that are essential for leukocyte adhesion to endothelial cells and chemotaxis. A small number of patients with leukocyte adhesion deficiency-1 have a milder defect, with residual expression of CD18. These patients tend to survive beyond infancy; they manifest progressive severe periodontitis, alveolar bone loss, periodontal pocket formation, and partial or total premature loss of the primary and permanent dentitions. We report on a 13-year-old boy with moderate leukocyte adhesion deficiency-1 and severe prepubertal periodontitis. This case illustrates the need for the dentist to work closely with the pediatrician in the prevention of premature tooth loss and control of oral infection in these patients.- - - - - - - - - - ranking = 1keywords = periodontitis (Clic here for more details about this article) |
2/9. Destructive membranous periodontal disease (Ligneous periodontitis).Generalized membranous gingival enlargement due to accumulation of amyloid or fibrin-like material is a rare, destructive and poorly defined disease entity. Some patients also show extraoral manifestations. The lesion is an involvement of periodontal tissues caused by the same process as ligneous conjunctivitis. In this report, 3 new cases, two of whom are siblings, are presented. Defective fibrinolysis and abnormal wound healing seem to be the main pathogenetic mechanism of this unusual disease, which should be evaluated systemically considering other mucosal involvement.- - - - - - - - - - ranking = 2keywords = periodontitis (Clic here for more details about this article) |
3/9. C-1 esterase inhibitor dysfunction localised to the periodontal tissues: clues to the role of stress in the pathogenesis of chronic periodontitis?BACKGROUND: C1-esterase inhibitor (C1eIn) is an important modulator of complement activation via the classical pathway. Deficiencies or dysfunction involving this inhibitor underlie the condition of angioneurotic oedema. AIM: The purpose of this report is to describe a female patient who presented at the age of 24 years with an apparently aggressive form of periodontitis and severe oedema, localised to the free gingival tissues. After 21 years of repeated surgical reduction of the gingiva, a diagnosis of C1eIn dysfunction was made. methods: Exhaustive serological investigations were performed along with histopathology. RESULTS: All investigations were unremarkable, until the function of the C1eIn molecule was investigated. These demonstrated a functional activity of only 29% and a raised C1q at 157 mg/l. Subsequent repeated investigation with careful specimen handling demonstrated undetectable levels of C1eIn and normal C1q. A diagnosis of C1eIn dysfunction was made, although at present it is unclear whether this represents an unusual variant of hereditary dysfunctional C1eIn deficiency. The patient was managed by various means, including steriodal and non-steroidal drugs, the latter forming part of her maintenance regime. CONCLUSIONS: To our knowledge, this is the first case of angio-oedema localised to the free gingiva. The role of stress in the acute exacerbations of oedema and bone loss is discussed along with the diagnostic pitfalls associated with this case.- - - - - - - - - - ranking = 2.5keywords = periodontitis (Clic here for more details about this article) |
4/9. Destructive membranous periodontal disease (ligneous periodontitis): a case report and 3 years follow-up.Destructive membranous periodontal disease is a rare, destructive and poorly defined entity, which is the part of a systemic disease due to plasminogen deficiency and fibrin deposition. The disease is characterised by gingival enlargement and periodontal tissue destruction that leads to rapid tooth loss despite treatment attempts. biopsy is essential to rule out other periodontal disease in the differential diagnosis.- - - - - - - - - - ranking = 2keywords = periodontitis (Clic here for more details about this article) |
5/9. Intraoral pyogenic granuloma after allogeneic bone marrow transplant. Report of three cases.Allogeneic bone marrow transplant patients commonly have oral complications related to their disease or its treatment. Those reported include: xerostomia, mucositis, caries, infection, gingival hyperplasia, periodontitis, and graft-versus-host disease. These complications may be responsible for significant morbidity. This article reviews commonly reported oral complications of bone marrow transplantation and presents three cases in which intraoral pyogenic granuloma occurred. The cause of these lesions in post-bone marrow transplant patients is discussed.- - - - - - - - - - ranking = 0.5keywords = periodontitis (Clic here for more details about this article) |
6/9. Periodical gingival bleeding as a presenting symptom of periodontitis due to underlying cyclic neutropenia. Case report.A 13-year-old boy presenting with spontaneous and periodical gingival bleeding accompanied by fever was thoroughly examined in order to determine the underlying aetiology of the gingival bleeding. Following repeated blood tests, the patient was diagnosed as having cyclic neutropenia. Thus, it was suggested, gingival bleeding, especially when spontaneous and periodical, should be carefully investigated to eliminate the possibility of cyclic neutropenia.- - - - - - - - - - ranking = 2keywords = periodontitis (Clic here for more details about this article) |
7/9. Unusual gingival enlargement with rapidly progressive periodontitis. Report of a case.A 15-year-old female patients suffered from recurrent unusual enlargement of the gingiva together with rapidly progressive alveolar bone loss. The enlarged gingiva completely covered her anterior teeth and protruded from the mouth. Marked inflammatory edematous tissue, which predominantly contained plasma cells, was observed in the connective tissue. Rapidly progressive alveolar bone loss was observed radiographically. The serum antibody titer to porphyromonas gingivalis, measured by ELISA, was much higher than that in healthy individuals. The diagnosis was unusual gingival enlargement with rapidly progressive periodontitis. Conventional periodontal therapy, including plaque control, scaling, root planing, and surgical removal of the soft tissue, did not produce complete healing of the gingival lesion, although recurrence of gingival enlargement and further loss of the periodontal attachment level were well controlled. After the periodontal treatments, the serum antibody titer to P. gingivalis decreased to normal levels. This unusual gingival enlargement was considered due to systemic factors that exaggerated the gingival response to local irritation and altered the usual clinical features of chronic gingivitis; local plaque irritation produced the extensive and recurrent enlargement of the gingiva. Under these circumstances, infection or overgrowth of periodontopathic bacteria, including P. gingivalis, might occur and the alveolar bone loss would then advance very rapidly.- - - - - - - - - - ranking = 2.5keywords = periodontitis (Clic here for more details about this article) |
8/9. Periodontal disease in three siblings with familial neutropenia.The periodontal status and treatment of three teenagers in a Finnish family with familial neutropenia is described. The mother was also diagnosed with neutropenia. At initial examination, the 15-year-old male and the 10-year-old female had severe periodontitis, whereas the 13-year-old male had oral ulcerations but no significant periodontal disease. The two siblings with periodontitis were treated and followed approximately 5 years. It was concluded that periodontal therapy including scaling, surgery, and use of antimicrobial agents can be successful in patients with familial neutropenia, and that such patients are not necessarily candidates for full mouth extraction. The role of granulocyte colony-stimulating factor in which was used in the treatment of these patients remains to be established.- - - - - - - - - - ranking = 1keywords = periodontitis (Clic here for more details about this article) |
9/9. Oral-dental findings in a case of Maffucci's syndrome.A case of Maffucci's syndrome (MS) in a 17-year-old Caucasian female is presented with a thorough intraoral examination. The prominent finding was recurrent gingival hyperplasia affecting both the free and attached gingiva with deep periodontal pockets, tooth mobility, pathological tooth migration, and severe alveolar bone loss. Furthermore, the pattern of alveolar bone destruction, in many ways, resembled that of localized juvenile periodontitis. Although there is always the possibility that these oral features may not be related with the syndrome, we suggest a careful dental and periodontal examination in future cases, which we believe will help develop a better description of oral findings in MS.- - - - - - - - - - ranking = 0.5keywords = periodontitis (Clic here for more details about this article) |