1/21. Necrotizing ulcerative periodontitis associated with severe congenital immunodeficiency in a prepubescent subject: clinical findings and response to intravenous immunoglobulin treatment.common variable immunodeficiency (CVID) is a rare multifactorial congenital disease of genetic origin caused by an impairment in the secretion of specific immunoglobulins. It manifests systemically through recurrent respiratory infections, gastrointestinal disorders and autoimmune diseases. oral manifestations may include gingivitis and lichenoid lesions with Wickham's striae. The treatment for CVID is supported by using intravenous infusion of immunoglobulins (IVIG) that allows for control of the disease and avoidance of recurrent opportunistic infections. This report presents a case of necrotizing ulcerative periodontitis (NUP) in a young patient with CVID, and correlates his periodontal status with systemic conditions before and after IVIG administration during 1 year of evaluation.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
2/21. Gingival disease associated with a decorative crown.Decorative crowns for the teeth have gained a resurgence of popularity among adolescents. Similar to other forms of body art found in the mouth, these trendy crowns may be associated with a variety of oral complications. This case report describes a localized form of necrotizing ulcerative gingivitis, exacerbated by a cosmetic gold crown in a teenage girl. Healthier artistic options are discussed to replace this flashy dental fad.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
3/21. Developmental absence of the premolar teeth: dental management.A boy aged 11 years presented with dental pain, several carious teeth and a localized area of acute necrotizing ulcerative gingivitis (ANUG). Developmental absence of the premolar teeth was notable and additional anomalies included mid-facial hypoplasia, mandibular prognathism, transposed teeth and delayed exfoliation of the deciduous teeth. These abnormalities have significant oral, dental, orthodontic and orthognathic implications.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
4/21. Oral pemphigoid masquerading as necrotizing ulcerative gingivitis in a child.BACKGROUND: Cicatricial pemphigoid (benign mucous membrane pemphigoid) is an autoimmune vesiculobullous disease that affects mucosal tissues of adults and rarely presents in children. Only 9 cases in the English literature have reported cicatricial pemphigoid in children, primarily as oral mucosal lesions. This paper presents a case of childhood cicatricial pemphigoid that clinically manifested as necrotizing ulcerative gingivitis (NUG). methods: A 9-year-old girl presented with gingival bleeding and discomfort for 2 weeks. NUG was suspected and the patient was treated with antibiotics and an oral hygiene regimen. When the condition did not improve after repeated treatment trials, routine hematoxylin and eosin (H&E) and direct immunofluorescence examinations were performed. RESULTS: Microscopic examination of H&E stained sections showed a non-specific ulceration with chronic inflammation. Direct immunofluorescence studies of peri-lesional tissue showed linear deposition of C3 at the basement membrane zone that was consistent with a diagnosis of cicatricial pemphigoid. CONCLUSION: Cicatricial pemphigoid is an autoimmune ulcerative condition that is rarely seen in children. Immunofluorescence studies are essential to differentiate this condition from other ulcerative oral lesions.- - - - - - - - - - ranking = 5keywords = necrotizing (Clic here for more details about this article) |
5/21. Fatal necrotizing stomatitis due to trichoderma longibrachiatum in a neutropenic patient with malignant lymphoma: a case report.Primary invasive mold infection of the oral cavity is a rare but serious complication in immunocompromised hosts. We report a case of fatal trichoderma longibrachiatum stomatitis in a 66-year-old female patient with malignant lymphoma. The infection rapidly disseminated from the oral mucosa to the lungs during neutropenia. Despite intensive antifungal therapy with amphotericin b and itraconazole, there was a fatal progression of the condition. While trichoderma species have been recognized to be pathogenic in profoundly immunosuppressed hosts, this is the first report of the primary oral focus causing a fatal infection.- - - - - - - - - - ranking = 4keywords = necrotizing (Clic here for more details about this article) |
6/21. Acute myelogenous leukemia complicated by acute necrotizing ulcerative gingivitis due to aspergillus terreus.Infections caused by aspergillus terreus are rare but have been associated with a poor outcome in immunocompromised patients due to frequent resistance to conventional antifungal therapy. This report describes a case of a woman who developed acute necrotizing ulcerative gingivitis (ANUG) due to A. terreus during induction chemotherapy for acute myelogenous leukemia. She initially failed to respond to treatment with amphotericin b but the infection resolved following the introduction of oral itraconazole. opportunistic infections caused by A. terreus are an emerging problem and can be associated with a high mortality rate. Early microbiological diagnosis is critical since resistance to amphotericin b is likely and itraconazole appears to be an effective treatment for this infection.- - - - - - - - - - ranking = 5keywords = necrotizing (Clic here for more details about this article) |
7/21. Necrotizing stomatitis: report of 3 pseudomonas aeruginosa-positive patients.Necrotizing oral lesions have been described in immunosuppressed patients, usually in association with gingival and periodontal pathoses. The etiology of these lesions has not been completely elucidated. We present 3 patients with a type of necrotizing stomatitis in which clinical patterns appear distinct from the periodontal forms of the disease. The lesions yielded bacterial cultures positive for pseudomonas aeruginosa and reverted to no growth in 2 patients after proper antibiotic therapy. We propose that P aeruginosa may be responsible for selected necrotizing oral lesions with a clinical presentation lacking typical necrotizing periodontal disease and that this condition may represent the intraoral counterpart of ecthyma gangrenosum. In such cases, bacterial culture of the lesion becomes imperative because the disease does not respond to typical periodontal and antimicrobial therapy.- - - - - - - - - - ranking = 3keywords = necrotizing (Clic here for more details about this article) |
8/21. Acute necrotizing ulcerative gingivitis and bacteremia caused by stenotrophomonas maltophilia in an immunocompromised host.An 8-year-old girl with leukemia developed acute necrotizing ulcerative gingivitis with stenotrophomonas maltophilia and herpes simplex virus. Progression to bacteremia with pathologic evidence of osteomyelitis occurred despite appropriate antimicrobial therapy. This case highlights the importance of prompt recognition, debridement and appropriate therapy in immunocompromised patients with acute necrotizing ulcerative gingivitis.- - - - - - - - - - ranking = 6keywords = necrotizing (Clic here for more details about this article) |
9/21. Complex oral manifestations of an hiv-seropositive patient.A complex manifestation of characteristic oral lesions occurring simultaneously in an hiv-seropositive patient is presented. Necrotizing ulcerative gingivitis (NUG), necrotizing ulcerative periodontitis (NUP), oral-facial herpes infection, pseudomembranous candidiasis and atypical oral ulceration are discussed. In spite of extremely low CD4 T-cell counts of 3 x 10(6)/L and lack of anti-retroviral therapy, an AIDS patient responded favourably to standard periodontal therapy. In the follow-up period of 3 months, no recurrence of any of the oral lesions initially present occurred and no special prophylactic regimes were needed to maintain oral health. This case illustrates that appropriate management of the oral manifestations contributes significantly to improvement of the quality of life of patients in the terminal stage of hiv-AIDS.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
10/21. Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report.A case of necrotizing ulcerative periodontitis (NUP), the most severe inflammatory periodontal disorder caused by plaque bacteria, is shown. Clinically, the gingiva showed distinct signs of ulceration, and radiography revealed horizontal bone loss. Indirect immunofluorescence, carried out on frozen sections of tissue specimens obtained from the NUP lesion, exhibited clear expression of atypical keratin K19, particularly in basal cells, when compared to noninflamed gingiva. Moreover, NUP tissue showed extensive intraepithelial abundance for the basement membrane component laminin-1/10 and the extracellular matrix molecule tenascin. Strong expression of integrin subunit alphav and matrix metalloproteinase-13 in conjunction with interleukin 1-beta further discriminated NUP gingival epithelium from normal tissue. The results suggest that NUP is associated with changes in the expression and topography of the analyzed molecules in the gingival epithelium, which in turn may reflect the fast progression of the disease.- - - - - - - - - - ranking = 5keywords = necrotizing (Clic here for more details about this article) |
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