1/11. Neovascular glaucoma as a complication of retinal vasculitis in crohn disease.PURPOSE: To report a case of neovascular glaucoma as a complication of retinal vasculitis in crohn disease. methods: Case report with fluorescein angiogram. RESULTS: A 62-year-old man with biopsy-proven crohn disease presented with bilateral uveitis, bilateral iris new vessels, and neovascular glaucoma in the left eye. fluorescein angiography revealed signs of retinal vasculitis and capillary nonperfusion in both eyes. CONCLUSION: crohn disease may be associated with retinal vasculitis and, thus, neovascular glaucoma. A satisfactory result can be achieved by using corticosteroids to control the retinal vascular inflammation, by applying panretinal photocoagulation and by controlling the increased intraocular pressure surgically.- - - - - - - - - - ranking = 1keywords = iris (Clic here for more details about this article) |
2/11. iris neovascularization in children as a manifestation of underlying medulloepithelioma.PURPOSE: To report the occurrence of unilateral iris neovascularization in children secondary to medulloepithelioma. methods: Presenting features and the clinical course of patients confirmed to have medulloepithelioma were reviewed. RESULTS: Seven patients with medulloepithelioma had iris neovascularization during the clinical course. Associated cataract and lens coloboma occurred in two and three cases, respectively. In six (86%) cases, no apparent cause for iris neovascularization could be detected at presentation. Two cases had tube shunts for management of neovascular glaucoma before medulloepithelioma was recognized. All cases eventually required enucleation. CONCLUSION: Presence of iris neovascularization is an early manifestation of medulloepithelioma. Children with iris neovascularization of unknown cause should be evaluated to exclude underlying medulloepithelioma.- - - - - - - - - - ranking = 5keywords = iris (Clic here for more details about this article) |
3/11. Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 x 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.- - - - - - - - - - ranking = 1keywords = iris (Clic here for more details about this article) |
4/11. Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma.PURPOSE: To describe a case with motile cyst in the anterior chamber in the right eye of a 7-year-old boy. methods: The right eye's visual acuity was 20/50. intraocular pressure was 59 mmHg. Slit-lamp examination showed prominent rubeosis iridis and a grey-white mass floating freely in the anterior chamber. Ultrasound biomicroscopy revealed a cystic mass in the anterior chamber. A diagnostic cyclectomy with removal of the anterior chamber cyst was performed. Histopathology of the anterior chamber lesion showed an intact cyst composed of medullary epithelial cells. Medulloepithelioma with malignant criteria was diagnosed and the eye was enucleated. RESULTS: pathology demonstrated an medulloepithelioma with a few mitotic figures and nuclear pleomorphisms within the ciliary body. The patient was followed for 8 months without any metastasis in the orbit or elsewhere. CONCLUSION: Intraocular medulloepithelioma is a rare embryonic benign or malignant neoplasm typically diagnosed in the first decade of life as a ciliary body mass. A dislodged, free-floating anterior chamber cyst associated with neovascular glaucoma is typical of medulloepithelioma in children. This unique presentation should be differentiated from congenital iris epithelial, post-traumatic, epithelial, parasitic and neoplastic cysts. Ultrasound biomicroscopy is useful for analysing the structure of the anterior segment mass. ciliary body medulloepithelioma is characterized by echogenic mass heterogeneity and an irregular surface containing multiple cystic cavities. Lack of glial differentiation may predict a better clinical outcome in primary neuroectodermal brain tumours.- - - - - - - - - - ranking = 1keywords = iris (Clic here for more details about this article) |
5/11. Intracameral bevacizumab for iris rubeosis.PURPOSE: To determine whether intracameral bevacizumab decreases vascular leakage from iris rubeosis in patients with neovascular glaucoma. DESIGN: Interventional case series. methods: The study included six eyes of three patients with secondary neovascular glaucoma due to proliferative diabetic retinopathy (n = 2) or ischemic central retinal vein occlusion (n = 1). All patients received an intracameral injection of 1.0 mg bevacizumab. Morphologic changes and vascular leakage were investigated prospectively by iris fluorescein angiography. RESULTS: Decrease in leakage was detected as early as one day after injection. No inflammation was observed. No relapse was seen within the follow-up of four weeks. CONCLUSION: Intraocular injection of bevacizumab may provide an additional strategy for the treatment of iris rubeosis in neovascular glaucoma.- - - - - - - - - - ranking = 7keywords = iris (Clic here for more details about this article) |
6/11. Rubeosis and anterior segment ischemia associated with systemic cryoglobulinemia.PURPOSE: To report two cases of iris neovascularization associated with systemic cryoglobulinemia. DESIGN: Retrospective case report. methods: Patient chart review and review of literature. RESULTS: Two patients with iris neovascularization in the absence of retinal ischemia were subsequently found to have systemic cryoglobulinemia. Successful treatment of one patient's underlying lymphoma led to stabilization and resolution of neovascularization. CONCLUSIONS: Systemic cryoglobulinemia may be associated with anterior segment ischemia and neovascularization, and should be considered in the differential diagnosis of iris neovascularization in the absence of apparent retinal ischemia.- - - - - - - - - - ranking = 3keywords = iris (Clic here for more details about this article) |
7/11. Intravitreal bevacizumab (Avastin) in the treatment of neovascular glaucoma.PURPOSE: To describe a case series of neovascular glaucoma (NVG) caused by central retinal vein occlusion (CRVO) that was treated with intravitreal bevacizumab (IVB; Avastin). DESIGN: Retrospective interventional case series. methods: Six consecutive patients with NVG and a refractory, symptomatic elevation of intraocular pressure (IOP) and pronounced anterior segment congestion received IVB (1.25 mg/0.05 ml). Diode laser cyclophotocoagulation was carried out only if pressure was controlled insufficiently by topical medication. Follow-up examinations occurred at four to 16 weeks. RESULTS: IVB resulted in a marked regression of anterior segment neovascularization and relief of symptoms within 48 hours. IOP decreased substantially in three eyes; in the other three eyes, adjuvant cyclophotocoagulation was necessary. No side effects were observed. Panretinal photocoagulation (PRP) was performed as soon as feasible, five to 12 weeks after IVB treatment. CONCLUSION: IVB leads to a rapid regression of iris and angle neovascularization and should be investigated more thoroughly as an adjunct in the management of NVG.- - - - - - - - - - ranking = 1keywords = iris (Clic here for more details about this article) |
8/11. Chronic ocular ischemia and neovascular glaucoma: a result of extracranial carotid artery disease.Severe occlusive disease of the carotid artery may produce a rare syndrome of chronic ocular ischemia. Prolonged retinal hypoxia is associated with characteristic funduscopic changes and neovascularization of the iris, with subsequent obstruction of aqueous humor resorption. A case of neovascular glaucoma as a result of severe bilateral carotid occlusive disease and the pathophysiology involved are discussed. Definitive treatment consisted of carotid endarterectomy and aggressive control of intraocular pressure, including operative placement of a drainage implant in the anterior chamber of the eye. Seizure activity and an exacerbation of glaucoma developed after successful revascularization, exemplifying the derangements in cerebral and ocular function that may result from chronic hypoperfusion.- - - - - - - - - - ranking = 1keywords = iris (Clic here for more details about this article) |
9/11. Severe ischemic process in a young man with central retinal vein occlusion.A 32-year-old man with central retinal vein occlusion followed by severe and rapidly progressing neo-vascular glaucoma is presented. This case was characterized by a severe ischemic process, in which the rubeosis iridis was followed by almost total atrophy of the iris within a short period of time. The onset of the central retinal vein occlusion was associated with mild dehydration and stress polycythemia following strenuous physical activity.- - - - - - - - - - ranking = 1keywords = iris (Clic here for more details about this article) |
10/11. Diabetic iris neovascularization.PURPOSE: To compare the validity of careful slit-lamp biomicroscopic examination of the pupillary margin to screening gonioscopic examination in the early detection and prevention of neovascular glaucoma in diabetic patients. methods: We examined two patients with histories of diabetes mellitus. RESULTS: Angle neovascularization developed before iris neovascularization in both patients. CONCLUSION: We believe screening gonioscopic examination is valuable in patients with diabetes.- - - - - - - - - - ranking = 5keywords = iris (Clic here for more details about this article) |
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