1/29. Radiation-induced gliomas: report of 10 cases and review of the literature.BACKGROUND: radiotherapy and more recently radiosurgery represent important therapeutic methods for the treatment of tumors and arterovenous malformations affecting the central nervous system, even though several significant side-effects have been described (radionecrosis, tumors, etc.). Gliomas induced by radiation therapy are decidedly unusual, and the first descriptions of this association only appeared in the 1960s. methods: The pertinent literature was reviewed to yield 116 cases in which a glioma developed after radiotherapy for cranial pathologies (included 10 personal cases treated in our Institution). One of our patients had undergone radiosurgery for a cavernous angioma. RESULTS: patients who developed a radiation-induced glioma were younger, as a group, than those affected with so-called "spontaneous" gliomas. The tumor originated in the previously irradiated area, after average doses of 32 Gy and an average latency period of 9.6 years in accordance with the findings reported by the authors and in our experience as well. radiotherapy had most frequently been performed for acute lymphoblastic leukemia. Our Case 10 is the fourth case of intracranial tumor arising after radiosurgery to be described in the literature. CONCLUSIONS: Though rare, gliomas may represent a late complication of radiation treatment. The behavior of the radiation-induced variety of glioma does not seem to differ significantly from that of its "spontaneous" counterpart. Late complications of the radiosurgery are probably underestimated because of the relatively recent introduction of this technique. On the contrary, these should be scrupulously evaluated when deciding whether to employ this method for therapeutic purposes for relatively benign or congenital lesions (which generally affect young patients with a long life expectancy).- - - - - - - - - - ranking = 1keywords = radiation-induced, leukemia (Clic here for more details about this article) |
2/29. Brainstem glioma after radiation therapy for acute myeloblastic leukemia in a child with down syndrome. Possible pathogenetic mechanisms.A 13-year-old boy with down syndrome (DS) had a brainstem glioma confirmed at autopsy, 10 years after receiving prophylactic cranial irradiation for acute myeloblastic leukemia. There is no clear association of brain tumors with DS; despite a reported link between leukemia and glioma, a causal association with radiation therapy is more likely.- - - - - - - - - - ranking = 0.005625874895286keywords = leukemia (Clic here for more details about this article) |
3/29. Visual loss despite anticoagulation in radiation-induced optic neuropathy.Radiation therapy to the brain may produce necrosis and loss of function months after completion of the treatment. The case is presented of a 62-year-old man who developed radiation-induced optic neuropathy 2 years after treatment for a glioma of the left temporal lobe, despite being on anticoagulation therapy. Although anticoagulation appears to be beneficial in cerebral radiation necrosis, its usefulness in the treatment of radiation-induced optic neuropathy is unclear.- - - - - - - - - - ranking = 2.9971870625524keywords = radiation-induced (Clic here for more details about this article) |
4/29. radiotherapy and marfan syndrome: a report of two cases.marfan syndrome (MFS) is a heritable disorder of the connective tissue which has been linked to mutations in the FBN (fibrillin-1) gene. Murine knockouts of the FBN gene show increased interstitial fibrosis and TGF-beta (tumor growth factor-beta) gene activation. Abnormal TGF-beta expression has previously been linked to radiation-induced fibrosis, suggesting a possible link between MFS and increased late effects following radiotherapy. Herein we report two cases in which MFS patients treated with radical radiotherapy without undue acute or late radiotherapy toxicity suggesting that radiotherapy should not be withheld from MFS patients. MFS patients may provide a unique clinico-translational setting to test associations between FBN mutations, TGF-beta activation and the risk of tissue fibrosis.- - - - - - - - - - ranking = 0.49953117709206keywords = radiation-induced (Clic here for more details about this article) |
5/29. Multicentric glial brain tumors of a varying degree of differentiation in patient with chronic lymphocytic leukemia.Chronic lymphocytic leukemia is associated with an increased incidence of secondary neoplasms. Primary brain tumors are rarely seen; however, an increased risk relative to the general population has been observed in male patients with chronic lymphocytic leukemia. A case report of a 62-year-old man with progressive chronic lymphocytic leukemia and pronounced neurologic symptoms is presented. Richter's syndrome or brain infiltration with leukemia cells was clinically suspected and suggested by computed tomography findings. Progression of the neurologic symptoms rapidly continued and the patient died. Neuropathologic examination revealed multicentric glial tumors of a varying degree of differentiation located throughout the brain and cerebellum.- - - - - - - - - - ranking = 0.007501166527048keywords = leukemia (Clic here for more details about this article) |
6/29. Cerebellar malignant glioma after radiation therapy for suprasellar germinoma--case report.A 39-year-old male was discovered to have a malignant glioma in the right cerebellar hemisphere 8 years after surgical excision of a suprasellar germinoma and postoperative irradiation (4250 cGy). The clinical and pathological details are presented, and the literature on radiation-induced gliomas is reviewed.- - - - - - - - - - ranking = 0.49953117709206keywords = radiation-induced (Clic here for more details about this article) |
7/29. Radiation-induced intracranial malignant gliomas.The authors present seven cases of malignant gliomas that occurred after radiation therapy administered for diseases different from the subsequent glial tumor. Included among these seven are three patients who were treated with interstitial brachytherapy. Previously reported cases of radiation-induced glioma are reviewed and analyzed for common characteristics. Children receiving central nervous system irradiation appear particularly susceptible to induction of malignant gliomas by radiation. Interstitial brachytherapy may be used successfully instead of external beam radiotherapy in previously irradiated, tumor-free brain, and thus may reduce the risk of radiation necrosis.- - - - - - - - - - ranking = 0.49953117709206keywords = radiation-induced (Clic here for more details about this article) |
8/29. Radiation-induced osteosarcoma of the sphenoid bone.The case of a patient who developed osteosarcoma in the sphenoid bone 15 years after radiation therapy for a craniopharyngioma is reported. Radiation-induced osteosarcoma of the sphenoid bone has not been reported previously. Reported cases of radiation-induced osteosarcomas are reviewed.- - - - - - - - - - ranking = 0.49953117709206keywords = radiation-induced (Clic here for more details about this article) |
9/29. Gliomas in children following radiation therapy for lymphoblastic leukemia.Four children treated for acute lymphoblastic leukemia developed intracranial gliomas between 40 and 120 months following multiagent chemotherapy, prophylactic whole brain irradiation, and intrathecal methotrexate. The diagnosis of glioma was confirmed in each case with biopsy or autopsy. These children were part of a larger series of 73 patients with acute lymphoblastic leukemia treated at indiana University receiving 24 Gy as per the protocol guidelines of the Children's Cancer Study Group. Currently 42 patients of the original 73 children survive in continuous remission.- - - - - - - - - - ranking = 0.005625874895286keywords = leukemia (Clic here for more details about this article) |
10/29. Radiation-associated gliomas: a report of four cases and analysis of postradiation tumors of the central nervous system.Four cases of radiation-associated gliomas are described. All patients were white men, irradiated in childhood for craniopharyngioma, anaplastic ependymoma, retinoblastoma of the orbit, and Burkitt's lymphoma, respectively. The dose ranged from 1800 to 5900 rads, and the latency period was 5 to 25 years. All primary and secondary tumors were verified histologically, and no evidence of persistence of the primary tumors was found. All secondary tumors arose in the fields of irradiation. Ninety-six cases of radiation-induced tumors of the central nervous system have been reported in the literature to date. Twenty-four were gliomas and occurred mainly in young men.- - - - - - - - - - ranking = 0.49953117709206keywords = radiation-induced (Clic here for more details about this article) |
| | Next -> |