1/17. Congenital multiple plaque-like glomangiomyoma.Congenital glomus tumor is a rare clinical variant of glomus tumor, and glomangiomyoma is the least frequent histologic type of glomus tumor. We report a case of congenital multiple plaque-like glomangiomyoma in a 38-year-old man with multiple nodules and plaques on his left arm and forearm. Histopathologic study showed an angiomatous, nonencapsulated tumor with numerous highly folded dilated vascular lumina scattered throughout the dermis. The lumina were lined by a single layer of flat endothelial cells, and one to several rows of glomus cells were observed adjacent to the endothelial cells. Around large vessels, there was a gradual transition from glomus cells to elongated mature smooth muscle cells with thin and long "blunt-ended" nuclei. Immunohistochemically, there were strong positive reactions for cytoplasmic alpha-smooth muscle actin in glomus cells and smooth muscle cells, vimentin in glomus cells and endothelial cells, and desmin in the smooth muscle cells only. To our knowledge, this is the first case report of congenital multiple plaque-like glomus tumor with the microscopic appearance of a glomangiomyoma.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
2/17. Solitary glomus tumour.A 42-year-old woman developed a purplish, tender nodule on her wrist of 6 months duration. Histological examination showed a well-circumscribed lesion situated in the dermis and subcutis characterized by numerous, dilated thin-walled vascular spaces surrounded by sheets of glomus cells. The histological findings are characteristic of the diagnosis of an uncommon type of glomus tumour, known as glomangioma.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
3/17. Localized multiple glomus tumors of the face and oral mucosa.We describe a 54-year-old patient with an unusual localization of localized multiple glomus tumors. She had several nodules on the left mandibular area, lower lip, and anterior part of the buccal mucosa. A biopsy taken from the left mandibular area showed cystically dilated vessels lined by endothelial cells and a few outer layers of glomus cells in the dermis to subcutis. Localized multiple glomus tumors are rare, and both their facial and oral mucocal localization are extremely rare.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
4/17. Glomus tumour of the hard palate: case report and review.Glomus tumours are usually small benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities. They are rare in the oral cavity, only 18 cases having been reported in the medical journals to our knowledge. They arise from the epithelioid glomus cells that normally reside in the stratum retinaculare corii of the skin and are concerned with temperature regulation. We report the clinical, morphological and immunohistochemical features of a case of glomus tumour of the hard palate.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
5/17. diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle aspiration biopsy. A case report with cytologic, histologic and immunohistochemical studies.BACKGROUND: The majority of glomus tumor are small, benign neoplasms that arise from modified smooth muscle cells. They usually occur in the dermis or subcutis of the extremities. However, rare cases have been reported in the visceral locations, most often in the stomach. CASE: A 32-year-old woman presented with episodes of right upper quadrant pain. She was found to have a gastric tumor that was biopsied at another hospital, where the diagnosis of gastrointestinal stromal tumor (GIST) was made. Endoscopic ultrasound (EUS) performed at our institution revealed a gastric submucosal tumor that was then biopsied by fine needle aspiration (FNA). Cytology revealed cohesive clusters of uniform, round, small cells with ill-defined cytoplasmic borders and scanty, amphophilic cytoplasm. Nuclei were round, with smooth nuclear membranes and evenly distributed, dusty chromatin. Intermingled with those epithelioid cells were small, short, spindled, normal endothelial cells. Immunohistochemical studies performed on cell block showed that the tumor cells were negative for CD34, CD117, chromogranin, synaptophysin, desmin and AE1/AE3 and were strongly positive for SMA, HHF-35 and collagen type iv. glomus tumor was diagnosed and later confirmed by histology. CONCLUSION: EUS-guided FNA biopsy is efficient and permits adequate sampling for accurate diagnosis of gastric glomus tumor. Although rare, glomus tumor should be in the differential diagnosis among other gastric lesions, such as well-differentiated adenocarcinoma, epithelioid GIST and carcinoid tumor.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
6/17. Glomangioma of the hip.BACKGROUND: Glomus tumors may occur in any region of the body, but they are very rare in the hip. OBJECTIVE: To present the eighth reported case of a glomus tumor of the hip up to date. methods: This is a case report and a literature review. RESULTS: A 68-year-old man presented with severe pain and tenderness in the right hip, especially on palpation and in the sitting position. On physical examination, there was a soft palpable subcutaneous mass and severe tenderness in the right hip. Ultrasound revealed a hypervascular subdermal mass that was 2 cm in diameter. The lesion arose from the dermis and extended into the subcutaneous tissue. It was totally excised under local anesthesia. The histopathologic diagnosis was a glomangioma. The patient has been symptom free in the 2 months of follow-up. CONCLUSIONS: Glomus tumors should be kept in mind in the differential diagnosis of painful subdermal mass. Surgical excision of the lesion with a sufficient margin of surrounding normal tissue not only achieves the exact diagnosis but also results in adequate treatment. In case of the presence of malignant features, a wide excision is needed with a close follow-up of patient for regional or distant metastases.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
7/17. glomus tumor: a rare location in the upper lip.glomus tumor is a benign neoplasm composed of glomocytes and vessels in varying proportions. It appears as a single painful nodule typically found in the dermis and the subcutaneous tissue of the extremities. A rare appearance of the tumor in the upper lip is presented. Differential diagnosis (along with clinical, microscopic, and immunohistochemical findings) is discussed.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
8/17. Subungual glomus tumor diagnosis based on imaging.A 50-year-old woman had had tenderness of the nail bed of the right thumb for more than 20 years. For the previous 5 or 6 years, she had also had attacks of pain with exposure to cold, and deformity of the right thumb nail plate began to appear. There was red discoloration on the proximal aspect of the nail bed, and a longitudinal fissure on the distal aspect of the nail plate. ultrasonography showed a well-circumscribed hypoechoic area under the proximal aspect of the nail plate and the nail matrix. color Doppler ultrasonography showed subtle flow signals within the hypoechoic area. magnetic resonance imaging showed a well-circumscribed mass in the same place that the ultrasonography indicated. It was isointense to the dermis of the nail bed on the T1-weighted image and hyperintense on the T2-weighted image. radiography showed subtle dorsal bone erosion in the distal phalanx. Surgery was performed. Histologically, the diagnosis of a subungual glomus tumor was made. We diagnosed the exact location and size of the subungual glomus tumor by preoperative imaging and completely removed it easily and safely. Imaging is very useful for diagnosing tumors of the nail unit.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
9/17. Congenital plaque-type glomuvenous malformations presenting in childhood.BACKGROUND: Glomuvenous malformations (GVMs) are now considered a separate entity from venous malformations. The rarest type of GVM is the generalized congenital plaque-type GVM. OBSERVATIONS: We present 10 new cases of congenital plaque-type GVM and describe their clinical progression and treatment. Mutations in the glomulin gene were found in those patients who participated in the genetic study. CONCLUSIONS: Congenital plaque-type GVMs are unique in their congenital nature, extensive distribution, difficult to diagnose and treat, and progressive involvement after birth. Most cases are familial, yet affected relatives usually have only minor lesions. The lesions of congenital plaque-type GVM are severe, visible at birth, and usually mistaken for extensive venous malformations. vascular malformations are divided by hemodynamic type into slow-flow and fast-flow lesions. Slow-flow lesions are subcategorized as capillary, lymphatic, and venous.(1) Capillary malformations are flat, sharply demarcated, red-pink vascular stains of the skin commonly referred to as port-wine stains. These persist throughout life and are characterized histologically by dilated capillaries within the dermis. They slowly increase in size with age. Lymphatic malformations are spongelike collections of abnormal channels and spaces that contain clear lymphatic fluid, causing an excess of fluid to accumulate and dilate the lymphatic channels. This results in swelling of the affected area and, if extensive, can cause enlargement of soft tissues and bones.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
10/17. A clinicopathologic study of glomus tumor of the stomach.Glomus tumors are benign lesions and originate from modified smooth muscle cells of the glomus body. These tumors are commonly observed in the dermis or subcutis, but only rarely found in the stomach. Here we report a case of a 67-year-old patient in whom glomus tumor of the stomach was diagnosed after 10-day history of melena. We have reviewed the 13 cases selected from literature of gastric glomus tumor in Korean, including our case. The age of onset ranged from 30 to 68 years (median 54 y) with a strong female dominance (10 females and 3 males). The tumors typically presented with gastrointestinal bleeding or ulcerlike symptom, and 6 tumors had mucosal ulceration. The tumor sizes varied from 1.2 to 3.8 cm (median 2.5 cm), and all tumors presented in antrum of stomach. Microscopically, the tumors were well-circumscribed, and composed of uniform, small, round to polygonal cells. Mitotic activity was usually low. The characteristics of gastric glomus tumors in Korean patients are very similar to those of Western populations. Although gastric glomus tumors can be considered more likely benign, a small possibility of malignant behavior cannot be ruled out.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
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