1/11. The ultrastructure of a feminizing granulosa-theca tumor.A 13-year-old girl with evidence of hyperestrinism had a right ovarian tumor removed. This neoplasm was composed predominantly of granulosa cells and exhibited some changes of luteinization. The neoplastic cells displayed an investment of basement membrane material which was closely related to fibrillar collagen within the tumor. Scattered throughout the neoplasms were small numbers of cells with charcteristics of the theca and a few cells had cytoplasmic features suggestive of smooth muscle. The ultrastructural findings of eight similar tumors have been described. In none is the basement membrane material fully appreciated; nevertheless, the production of this extracellular material is a major and distinctive feature of granulosa-theca tumors.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
2/11. Testicular granulosa cell tumor of the adult type.A testicular granulosa cell tumor of the adult type was studied in a 61-year-old man with a history of diabetes and urinary bladder carcinoma. The tumor was composed of three areas, each with a distinctive histologic pattern: solid, cystic, and cordlike. Most of the tumor cells in the three patterns had a round to ovoid euchromatic nucleus with one or two large nucleoli and scanty cytoplasmic organelles, mainly mitochondria and rough endoplasmic reticulum. These cells showed slight immunopositivity for vimentin and no immunostaining for cytokeratins. Occasionally, elongated nuclei displaying membrane infoldings were observed. Pleomorphic nuclei were rare. The number of mitotic figures was low. Differential aspects of testicular and ovarian granulosa cell tumors are discussed.- - - - - - - - - - ranking = 0.5keywords = membrane (Clic here for more details about this article) |
3/11. Primary extraneural myxopapillary ependymoma of the broad ligament.Primary extraneural ependymomas are rare tumors that arise in ectopic sites, including pulmonary, sacrococcygeal region, ovarian, and paraovarian tissues. Four such ependymomas reported in the literature involve the paraovarian tissues, including 2 broad ligament ependymomas. Here we describe a myxopapillary ependymoma of the broad ligament in a 22-year-old woman, which may be the first tumor of this type to be reported in this location. Cytology, histology, cytochemistry, immunohistochemistry, and flow cytometry ploidy analysis are studied and described. Identification of perivascular ependymal rosettes, ependymal canals, vimentin and glial fibrillary acidic protein immunoreactivity, cytochemical staining of blepharoplasts or terminal bars by phosphotungstic acid hematoxylin, and presence of multiple foci of myxoid degeneration among the ependymal rosettes characterized a myxopapillary ependymoma.- - - - - - - - - - ranking = 221.23039742079keywords = ligament (Clic here for more details about this article) |
4/11. Testicular sex cord stromal tumour with granulosa cell differentiation: detection of steroid hormone receptors as a possible basis for tumour development and therapeutic management.A testicular sex cord stromal tumour with granulosa cell differentiation, typical of granulosa cell tumours of the adult type, was investigated immunohistologically on snap frozen and paraffin wax embedded material. The predominance of vimentin and the additional expression of cytokeratin subtypes 8 and 18, as well as the negative staining for epithelial membrane antigen, accorded with results previously reported, for ovarian granulosa cell tumours; the lack of expression of desmoplakin, however, was a distinctive feature. Together with negative staining for leucocyte common antigen, the antigen pattern facilitates the differential diagnosis between granulosa cell tumour and undifferentiated carcinoma or gonadal lymphoma, although its suitability for differentiating within the group of gonadal stromal tumours seems to be limited. The small growth fraction, shown by the monoclonal antibody Ki-67, is typical of the clinical behaviour of granulosa cell tumours. The expression of oestrogen and progesterone receptors, also recently found in testicular Leydig cell tumours, may provoke new approaches to the management of testicular granulosa cell tumours, as well as a new hypothesis on the development of these tumours.- - - - - - - - - - ranking = 0.5keywords = membrane (Clic here for more details about this article) |
5/11. Ovarian sex cord tumor with annular tubules.A pathologic study was done on four cases of ovarian sex cord tumor with annular tubules. All four tumors occurred in young women (11-24 years of age) and were not associated with the peutz-jeghers syndrome. Two patients had evidence of hyperestrinism. One patient who had metastasis to the retroperitoneum, left supraclavicular lymph node, and liver confirmed the malignant potential of this tumor. Gross examination revealed tumors that were solid, yellowish, and unilateral, with varying degrees of cystic degeneration. Microscopic examination showed simple or complex annular tubules with prominent basement membranes. Many tumor cells contained lipid in the cytoplasm. Ultrastructural study showed Charcot-Bottcher filaments in all four cases, indicating Sertoli cell differentiation. True lumens and microvilli were identified in one case. The classification of the sex cord tumor with annular tubules as a sertoli cell tumor, annular tubular type was proposed on the basis of ultrastructural findings.- - - - - - - - - - ranking = 0.5keywords = membrane (Clic here for more details about this article) |
6/11. Cytology of granulosa cell tumor of the ovary.granulosa cell tumor of the ovary may create a diagnostic challenge in cytologic preparations. Our experience with needle aspiration material, ascitic fluid, and peritoneal washings indicates that in fluids, despite some similarity between the tumor cells and reactive mesothelial cells, a correct diagnosis can be achieved by careful examination. The paucity of the cytoplasm and an intense indentation of nuclear membrane are the most helpful features in distinguishing the granulosa cells from mesothelial cells. The literature is reviewed, and the controversies regarding needle aspiration of ovarian neoplasms are discussed.- - - - - - - - - - ranking = 0.5keywords = membrane (Clic here for more details about this article) |
7/11. Ovarian sex cord tumors with annular tubules: an ultrastructural study.The ultrastructural features of two "sex cord tumors with annular tubules" are presented. The findings are compared with the reported fine structure of ovarian and testicular stromal cells and the cells of gonadal stromal neoplasms. The predominant cell in the "sex cord tumor with annular tubules" has some of the ultrastructural features found in gonadal stromal cells of either ovarian or testicular type; however, no Charcot-Bottcher crystals, lamellar bodies, crystalloids of Reinke, abundant smooth endoplasmic reticulum or complex plasma membrane interdigitations are observed in the tumor cells to suggest wither Sertoli or Leydig cell origin. The striking similarity between the predominant cell type and granulosa cells, as well as the presence of fibrillary material of the type seen in Call-Exner bodies, suggests a granulosa cell origin for these neoplasms. However, the presence of a sparsely distributed second cell type which closely resembles the dark cells in normal nonluteinized ovarian stroma indicates these tumors may arise from the nonspecialized ovarian stroma.- - - - - - - - - - ranking = 0.5keywords = membrane (Clic here for more details about this article) |
8/11. Ovarian sex cord tumors with annular tubules. An ultrastructural study of three cases.The ultrastructural features of three ovarian sex cord tumors with annular tubules were analyzed. The cells had deeply indented nuclei, interdigitating plasma membranes joined by abundant desmosomes, and numerous randomly distributed microfilaments that often complexed with desmosomes. Charcot-Bottchner crystalloids were absent. None of the tubular structures had true lumens. The characteristic central hyaline bodies resembled some forms of Call-Exner bodies and were composed of concentric layers of basal lamina, which often were continuous with redundant basal lamina of the peripheral basement membrane. Because of the clinical, histologic, and ultrastructural similarities to granulosa cell tumors and normal preovulatory granulosa cells, classification of the sex cord tumor with annular tubules is proposed as a distinctive annular and membranous variant of granulosa cell tumor.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
9/11. Laparoscopic surgical therapy and staging in a case of early malignant granulosa cell tumor of the ovary.An early right granulosa cell tumor was removed without rupture through the vaginal route after laparoscopic division of the ovarian ligament. Staging biopsies, peritoneal cytology, infracolic omentectomy, pelvic and right infrarenal para-aortic dissection were completed laparoscopically. The patient was discharged on the third day, and she is doing well 22 months postoperatively.- - - - - - - - - - ranking = 36.871732903466keywords = ligament (Clic here for more details about this article) |
10/11. Increased serum concentrations of type IV collagen and laminin associated with granulosa cell tumour of the ovary.A 65 year old woman presented with an ovarian mass. ultrasonography and computed tomography findings, and an increased serum oestrogen concentration were suggestive of an oestrogen producing ovarian tumour. The tumour was removed surgically and weighed 460 g. The pathological diagnosis was adult-type granulosa cell tumour. Strong immunohistochemical staining specific for type IV collagen and laminin was observed, and these components were localised to the pericellular region of the granulosa cells. The serum concentrations of these basement membrane components (measured by radioimmunoassay) were very high before surgery, but decreased rapidly thereafter. Serial measurement of type IV collagen and laminin, in conjunction with other tumour markers and oestrogen concentrations, might be helpful in evaluating prognosis of ovarian granulosa cell tumours, in detecting metastatic or recurrent lesions and in monitoring response to treatment.- - - - - - - - - - ranking = 0.5keywords = membrane (Clic here for more details about this article) |
| | Next -> |