1/9. Giant retroperitoneal hemangiopericytoma with paraneoplastic gynecomastia. Case report and literature review.We report on a 38-year-old patient with a giant retroperitoneal hemangiopericytoma associated with bilateral paraneoplastic gynecomastia, which led to an almost uncontrollable hemorrhage on initial surgery due to the extreme hypervascularity of the process. After angiographic evaluation and superselective embolization, a complete surgical excision of a hemangiopericytoma weighing almost 1,000 g could be achieved. To reduce the risk of recurrence adjuvant radiotherapy with 49 Gy followed. Follow-up of 24 months showed no sign of recurrence on CT scans. To our knowledge this is the first reported case of hemangiopericytoma associated with a paraneoplastic syndrome. The literature and the therapeutic concepts are presented and discussed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/9. gynecomastia in type-1 neurofibromatosis with features of pseudoangiomatous stromal hyperplasia with giant cells. Report of two cases.We describe the histological finding in two cases of gynecomastia in patients with von Recklinghausen's disease. The histological and immunohistochemical features of the two cases were reviewed and compared with those of five cases of gynecomastia in men without clinical evidence of neurofibromatosis. In both patients bearing von Recklinghausen's disease, the breast stroma showed features consistent with pseudoangiomatous stromal hyperplasia (PASH). It was characterised by anastomosing empty spaces lined by spindle and multinucleated giant cells which were positive with CD34 and anti-vimentin antisera and negative with anti-FVIII and CD31 antisera. In two of five of the control cases without neurofibromatosis, the mammary stroma showed focal areas with features of PASH, but no multinucleated giant cells were present in any case. PASH with giant cells should be recognised as a feature of gynecomastia in von Recklinghausen's disease. The presence of multinucleated giant cells is very unusual and, although more cases have to be studied, these cells seem to be a feature of PASH occurring in patients with von Recklinghausen's disease.- - - - - - - - - - ranking = 8keywords = giant (Clic here for more details about this article) |
3/9. gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung.OBJECTIVE: To describe a patient with human chorionic gonadotropin (hCG)-secreting giant cell carcinoma of the lung manifesting as painful gynecomastia, which resolved after surgical treatment. methods: We present the clinical, radiologic, and clinical course of our patient, who presented with painful gynecomastia. RESULTS: A 51-year-old man presented with a lung mass and rapidly progressing bilateral painful gynecomastia. Hormonal evaluation revealed high levels of hCG beta subunit, estradiol, and total and free testosterone and suppressed levels of luteinizing hormone and follicle-stimulating hormone. The patient underwent resection of the right upper and middle lobes of the lung. After the surgical procedure, the levels of hCG and estradiol rapidly decreased, and the gynecomastia resolved completely within 3 months. Fluctuation in the levels of serum hCG paralleled the clinical course of the lung tumor. CONCLUSION: Although gynecomastia is a common disorder, hormonal work-up including hCG beta subunit should be done in an adult male patient presenting with rapidly progressing or recent onset of painful gynecomastia. lung cancer should be considered in the differential diagnosis of gynecomastia attributable to ectopic production of hCG beta subunit.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
4/9. Giant cell fibroblastoma of the breast in a child--a case report and review of the literature.A case report and review of the literature are reported for giant cell fibroblastoma of the breast in a child. This is the first reported case of a congenital occurrence of this tumor type (giant cell fibroblastoma).- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
5/9. Multinucleated stromal giant cells in adolescent gynaecomastia.Bizzare multinucleated stromal giant cells were observed in a case of adolescent gynaecomastia. Similar cells have been described in the female breast in both benign and malignant conditions where they are thought to originate either from reactive stromal cells or from the mononuclear phagocyte system, respectively. immunohistochemistry and electron microscopy in this case support the idea that they originate from stromal fibroblasts. Their occurrence in gynaecomastia is further evidence that these changes in stromal cells may be due to hormonal influences.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
6/9. Gigantic cystosarcoma phyllodes in a man with gynecomastia.A 70-year-old man had a breast tumor for 50 years. The tumor, which weighed 8.6 kg, proved to be a malignant cystosarcoma phyllodes. It was successfully removed by a simple mastectomy with low axillary dissection, and a skin graft was performed. The lesion was associated with gynecomastia, and it is believed to have represented a cystosarcomatous transformation of a giant fibroadenoma.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
7/9. Resolution of prepubertal male gynecomastia following removal of a giant pigmented nevus.A male infant is reported in whom substantial gynecomastia resolved following removal of a giant pigmented nevus. Endocrinological studies were normal. It is postulated that the nevus contributed to the development of gynecomastia. Surgeons should be aware of a possible relationship between these two seemingly unrelated conditions when making evaluation and management decisions.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
8/9. Pseudogynecomastia due to neurofibromatosis--a light microscopic and ultrastructural study.A six year old boy with bilateral breast enlargement was found to have a normal endocrine status. Resected tissue revealed the features of pseudogynecomastia due to a proliferation of fibrous tissue traversed by neuroid structures. Multinucleated giant cells were present within the fibrous tissue. Ultrastructural study revealed organized nerve elements in a collagenous stroma. The multinucleated giant cells appeared to be variants of the predominant stromal fibroblasts.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
9/9. Gynaecomastia in a patient with a hCG producing giant cell carcinoma of the lung. Case report.Gynaecomastia, or enlargement of the male breast may result from various endocrine dysfunctions and often reflects ectopic production of substances such as hCG and estradiol. We report on the case of a 30 year old man who presented with gynaecomastia and elevated plasma levels of hCG, estradiol and testosterone. As a result of several diagnostic procedures such as selective venous sampling and magnetic resonance tomography (MRT), a hCG producing tumor of the upper lobe of the left lung was found. This hormonal overproduction induced an enhanced secretion of estradiol and testosterone in the testicular tissue. histology revealed a giant cell carcinoma with positive immunostaining for hCG. This case report further underlines the necessity of an intensive search for ectopic beta-hCG production due to malignant tumours, in particular in the adult.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |