1/4. Organic mental disorders associated with bupropion in three patients.bupropion hydrochloride is a phenylaminoketone antidepressant whose clinical pharmacology is poorly understood. Part of bupropion's action may be attributed to inhibition of dopamine reuptake that may induce organic mental disorders in certain susceptible patients. We report three cases of organic mental disorders in patients receiving bupropion hydrochloride for treatment of the depressed phase of their bipolar-type mood instability. The organic mental disorders that occurred in these patients were characterized largely by visual disturbances--visual hallucinations and visual illusions--although one patient also experienced auditory hallucinations. The patients' use of concomitant medications and potential drug interactions are carefully evaluated and the literature on bupropion's ability to induce organic mental disorders is reviewed. We suggest a number of possible mediating mechanisms for these syndromes including dose-related dopaminergic augmentation, accumulation of toxic metabolites, predisposition to psychosis, and drug interactions.- - - - - - - - - - ranking = 1keywords = mental disorder (Clic here for more details about this article) |
2/4. Progressive systemic sclerosis with mental disorder.We present a clinical case of a 43-year-old female with progressive systemic sclerosis, Basedow's disease, atrial fibrillation and diabetes mellitus. She twice developed exacerbations of a psychotic state. She showed a depressive state followed by a paranoic hallucinatory state and stupor. Electroencephalograms revealed slow abnormal records both in psychotic and remitting periods and 123I IMP SPECT of the brain showed a low blood flow in the psychotic stage. A case of progressive diffuse sclerosis with a paranoic hallucinatory state is rarely reported. As her Basedow's disease had been well controlled, the psychotic symptoms of the present case are regarded as organic hallucinosis and organic delusional disorder due to progressive diffuse sclerosis.- - - - - - - - - - ranking = 0.5keywords = mental disorder (Clic here for more details about this article) |
3/4. Musical hallucinations and hearing deficit in a young non-psychotic female.A case of musical hallucinations in a young non-psychotic female is described. The only presented symptoms were perceptual disturbances accompanied by the fear of having a severe mental disorder. Further investigation disclosed a perforated ear-drum, with subsequent mild hearing deficit but no signs of major psychopathology. It is suggested that a psychiatric diagnosis should be deferred in such patients, before audible deficits had been ruled out. The clinical features of musical hallucinations associated with hearing deficits are discussed.- - - - - - - - - - ranking = 0.125keywords = mental disorder (Clic here for more details about this article) |
4/4. True auditory hallucinations as a conversion symptom.Detailed descriptions of true hallucinations as a conversion symptom are rare in the psychiatric literature. The author presents a case with true conversive auditory hallucinations which paradigmatically demonstrates the usefulness of the concept in the treatment of such hallucinations. The phenomenon of true conversive hallucinations may contribute to the embryological understanding of mental disorders.- - - - - - - - - - ranking = 0.125keywords = mental disorder (Clic here for more details about this article) |