1/12. The hyperkeratotic variant of disseminated superficial actinic porokeratosis (DSAP).A 78-year-old South Korean man was referred to us from the Medical intensive care Unit (MICU) for an opinion. He was comatose and was on ventilatory care due to aspiration pneumonia. Multiple tiny papules had developed 10 years previously and since then the number and size had been increasing gradually. He had been diabetic for the past 4 years, and had Parkinson's disease diagnosed 1 year previously. Laboratory examinations revealed an elevated level of white blood cells (WBCs) (25,000/microL) and decreased hemoglobin (8.8 g/dL). Other laboratory results were negative or within normal limits. skin examination showed multiple, discrete, crust-like, brownish papules over the erythematous base on the face, upper extremities, and lower extremities. With the clinical impressions of irritated verruca vulgaris, seborrheic keratosis, or cutaneous fungal infection, a skin biopsy was taken from a papule on the left shin, and histopathologic examination revealed several pronounced hyperkeratotic and parakeratotic columns, and characteristic cornoid lamellae in the stratum corneum. Beneath the cornoid lamellae, the granular layer was decreased. A number of round or oval, dyskeratotic, homogenized eosinophilic cells with pyknotic nuclei were scattered in the prickle cell layer below the cornoid lamellae. A mild lymphohistiocytic infiltrate was observed in the papillary dermis and around the blood vessels in the upper dermis. Also, actinic degeneration was present in the upper dermis.- - - - - - - - - - ranking = 1keywords = vulgaris (Clic here for more details about this article) |
2/12. Keratotsis punctata of the palmar creases: report of two cases associated with ichthyosis vulgaris.Two patients with keratosis punctata of the palmar creases are described. The association with ichthyosis vulgaris and other disorders of keratinization is discussed. In both cases, histopathology revealed a close relation between the keratotic plug and the sweat glands. The role of genetic factors and manual activity in the pathogenesis is discussed. Treatment with oral etretinate resulted in a good improvement in the first patient, but prolonged low-dose maintenance therapy was required to prevent recurrence.- - - - - - - - - - ranking = 5keywords = vulgaris (Clic here for more details about this article) |
3/12. A rare association of systemic sclerosis with psoriasis vulgaris.Three patients with systemic sclerosis (SSc) and psoriasis vulgaris were evaluated. The onset of psoriasis preceded by 3-7 years the onset of SSc in all cases. All the patients presented diffuse scleroderma, accompanied by lung and esophageal involvement in two cases. sjogren's syndrome occurred in one case. myalgia developed with the onset of SSc in two patients. The PASI score was not high (mean; 5.2), implying that the degree of psoriasis was not severe in these cases. However, this might have been due to the systemic prednisolone administered for myalgia.- - - - - - - - - - ranking = 5keywords = vulgaris (Clic here for more details about this article) |
4/12. chromoblastomycosis: report of two cases from nepal.chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by dematiaceous fungi. The first case, a 67-year-old male farmer, presented with itchy hyperkeratotic, scaly plaques with scarring and black dots on the lateral aspects of his left arm and dorsum of his left hand of 28 years duration. The case was clinically diagnosed as chromoblastomycosis. The second case, a 75-year-old farmer, presented with erythematous, crusted, scaly plaques on the dorsum of the left foot of 30 years duration. Initially, a clinical diagnosis of lupus vulgaris was made, but treatment with anti tuberculosis therapy showed no improvement. On the basis of histopathological examinations of skin biopsies and isolation of fungus on culture, both cases were diagnosed as chromoblastomycosis. To the best of our knowledge, these two cases are the first case reports of chromoblastomycosis from nepal and are presented for their academic interest.- - - - - - - - - - ranking = 1keywords = vulgaris (Clic here for more details about this article) |
5/12. doxycycline-induced photo-onycholysis.An uncommon manifestation of phototoxicity, photo-onycholysis results in the separation of the distal nail from the nail bed. Photo-onycholysis may follow the use of various medications or may occasionally be idiopathic. We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris.- - - - - - - - - - ranking = 1keywords = vulgaris (Clic here for more details about this article) |
6/12. Giant verruca vulgaris.BACKGROUND: Common warts (verrucae vulgares) are hyperkeratotic papulonodules that are most often seen on the hands, arms, and legs, but they can be seen anywhere on the glabrous skin. Common warts represent the most frequent clinical lesions produced by the human papillomavirus (HPV). OBJECTIVE: Although they are diagnosed easily, giant, chronic, isolated, solitary, recalcitrant verruca vulgaris involving nail and nail bed on the digits can be misdiagnosed, and the differential diagnosis should be made carefully and verified by biopsies. METHOD: A 50-year-old male patient had a giant periungual verruca vulgaris on his left second finger. It was present for 2 years, was unresponsive to any treatment modality, and was treated by surgical excision. RESULTS: After 18 months of follow-up, there was no evidence of recurrence, and both aesthetic and functional results were quite satisfactory. CONCLUSION: Lesions of long duration generally lose their characteristic histopathologic features, and HPV cannot be detected in these lesions by polymerase chain reaction. Therefore, multiple sections should be examined histopathologically, and extreme care should be taken in order to avoid misdiagnosis.- - - - - - - - - - ranking = 6keywords = vulgaris (Clic here for more details about this article) |
7/12. Trachyonychia: case report and review of the literature.Trachyonychia is the term used to describe nail plate roughness, pitting, and ridging that may affect 1 to 20 nails. alopecia areata, psoriasis, lichen planus, atopic dermatitis, ichthyosis vulgaris, as well as other skin conditions have been associated with trachyonychia, but the causal relationship is often challenging to demonstrate histologically. Clinical evidence of these cutaneous disorders in conjunction with a nail matrix biopsy may help elucidate an etiology of trachyonychia, but many cases often remain idiopathic. Nail biopsy findings may match skin histology, but more commonly show spongiotic or nonspecific changes. We present an interesting case of a female with progressive development of trachyonychia in all 20 nails coinciding with a new diagnosis of sarcoidosis.- - - - - - - - - - ranking = 1keywords = vulgaris (Clic here for more details about this article) |
8/12. Pyogenic granuloma following treatment of verruca vulgaris with cryotherapy and Duoplant.We report an unusual case of pyogenic granuloma that appeared after the application of liquid nitrogen and 27 percent salicylic acid (Duoplant, Stiefel Inc.) to a verruca vulgaris. Only two cases of pyogenic granuloma following cryotherapy appear in the literature and pyogenic granuloma as a complication of salicylic acid application has not been documented.- - - - - - - - - - ranking = 5keywords = vulgaris (Clic here for more details about this article) |
9/12. Two cases of trichilemmal-like horn.We report two cases of cutaneous horn: one on the palm and one on the thumb. Microscopic examination of the lesion revealed trichilemmal-like keratinization that was unrelated to hair follicles. Each of these lesions most probably developed within a preexisting verruca vulgaris.- - - - - - - - - - ranking = 1keywords = vulgaris (Clic here for more details about this article) |
10/12. ichthyosis vulgaris palmaris et plantaris dominans: a peculiar form of ichthyosis vulgaris localized on the palms and soles.4 cases with congenital hyperkeratotic lesions localized on the palms and soles, occurring in three generations of one family, were observed. The atrophic, hyperkeratotic lesions accompanied by anhidrosis were dirty yellowish-brown coloured, with an ill-defined border but without any erythematous or pigmented halo. Further clinical findings were conspicuous dryness, adherent scale formation, fissurings and parchment paper-like luster. Histological findings were identical to those of ichthyosis vulgaris, with an absence of eccrine sweat glands. Hence, this type of hyperkeratosis can be distinguished from other types of inherited palmoplantar keratosis. For this peculiar form of dominantly inherited palmoplantar keratosis, the author proposed the new name 'ichthyosis vulgaris palmaris et plantaris dominans'.- - - - - - - - - - ranking = 10keywords = vulgaris (Clic here for more details about this article) |
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