1/114. leiomyosarcoma of the heart and its pulmonary metastasis, both with prominent osteoclast-like multinucleated giant cells expressing tartrate-resistant acid phosphatase activity.An autopsy case of cardiac leiomyosarcoma and its pulmonary metastasis, both with osteoclast-like multinucleated giant cells (OMGC) mimicking the so-called giant cell variant of malignant fibrous histiocytoma (MFH), is reported. The patient, a 70-year-old male, was admitted for sudden dyspnea. Extensive work-up established only a left atrial tumor mass. Three months after admission, the patient developed multiple intracranial and pulmonary metastases, followed by a worsening clinical course characterized by semicoma and dyspnea, and subsequently died 6 months after the onset of his symptoms. At subsequent autopsy, the left atrial polypoid tumor was found to have invaded destructively to the left half of the cardiac wall. histology of the cardiac tumor revealed a bimorphic sarcoma in which a poorly differentiated leiomyosarcoma comfirmed by histologic and immunohistochemical findings was juxtaposed to a small nodule with features closely mimicking giant cell MFH. The pulmonary metastatic nodules exhibited features that were entirely indistinguishable from giant cell MFH except for the fact that a minority of polymorphic cells manifested myogenic differentiation. We believe that such a MFH-like pattern represents a pleomorphic form of leiomyosarcoma rather than a dedifferentiated one. The OMGC within the MFH-like component coexpressed CD68 and tartrate-resistant acid phosphatase activity.- - - - - - - - - - ranking = 1keywords = histiocytoma (Clic here for more details about this article) |
2/114. In utero diagnosis of cardiac hemangioma.Fetal cardiac hemangioma is rarely diagnosed prenatally. We present here a fetus with such a tumor diagnosed at 28 weeks' gestation. With the use of fetal echocardiography, a mixed echogenic mass protruding outward from the right atrial wall was observed. Moderate amounts of pericardial effusion were also found. Although no apparent blood flow signal was detected in the mass, fetal echocardiography showed signs suggestive of a hemangioma. Differential diagnosis, management and prognosis are discussed.- - - - - - - - - - ranking = 0.25866956895515keywords = hemangioma (Clic here for more details about this article) |
3/114. Cardiac explantation and autotransplantation.Cardiac explantation and autotransplantation is a procedure by which the heart is removed from the chest and replaced. Explantation of the heart for tumor removal has been documented six times in the literature; however, with this aggressive approach, the median patient survival rate is only eight months. This article presents a case study in which this procedure was used to treat a patient with malignant fibrous histiocytoma.- - - - - - - - - - ranking = 1keywords = histiocytoma (Clic here for more details about this article) |
4/114. Left ventricular hemangioma.Cardiac hemangiomas are rare, primary benign cardiac tumors. The authors report their experience of diagnosis and treatment of an hemangioma localized into the left ventricle. The tumor could be successfully resected and there is no recurrence at 1 year follow-up.- - - - - - - - - - ranking = 0.25866956895515keywords = hemangioma (Clic here for more details about this article) |
5/114. A case of interleukin-6-producing malignant fibrous histiocytoma originating in the heart.Primary cardiac malignant fibrous histiocytoma is extremely rare and its pathophysiological characteristics remain largely unknown. We treated a female patient with persistent fever and disseminated intravascular coagulation. Since ultrasonic echocardiography revealed the presence of a cardiac tumor and her serum interleukin-6 level was elevated, we speculated she had a cardiac myxoma. Histological examination of the surgically resected specimen, however, revealed that the tumor was malignant fibrous histiocytoma. Although her disseminated intravascular coagulation and heart failure were transiently improved after operation, local recurrence and systemic metastasis occurred and she died 7 weeks after operation. Using the autopsied specimen, we examined whether the malignant fibrous histiocytoma constitutively synthesized interleukin-6. The interleukin-6 content in the tumor was high, consistent with interleukin-6 production by the tumor. This was confirmed by immunohistochemical analysis. To our knowledge, this is the first report demonstrating interleukin-6 production by a cardiac malignant fibrous histiocytoma.- - - - - - - - - - ranking = 8keywords = histiocytoma (Clic here for more details about this article) |
6/114. Resection of a large right atrial hemangioma in a neonate after prenatal diagnosis.Cardiac hemangiomas are extremely rare benign tumors. We describe the case of a right atrial hemangioma in a neonate diagnosed prenatally and successfully operated 10 days after spontaneous delivery. This unusual case illustrates the importance of prenatal diagnosis and delivery of the baby next to a pediatric center with a department of appropriately specialized cardiovascular surgery.- - - - - - - - - - ranking = 0.25866956895515keywords = hemangioma (Clic here for more details about this article) |
7/114. Survival following treatment of a cardiac malignant fibrous histiocytoma.The authors report the successful surgical and chemotherapeutic management of a malignant fibrous histiocytoma with localization in the heart. This rare malignancy has specific morphologic characteristics and is diagnosed in adults when it is already locally aggressive or metastasized. The average survival time for patients with malignant fibrous histiocytoma is < 12 months. Neither clinical nor instrumental signs of recurrence have been detected in this patient after an aggressive surgical resection and a specific therapeutic approach.- - - - - - - - - - ranking = 6keywords = histiocytoma (Clic here for more details about this article) |
8/114. hemangioma of the right ventricular outflow tract.Obstruction of the right ventricular outflow tract by a primary cardiac tumor is rare. Six cases of right ventricular outflow tract obstruction by a primary cardiac hemangioma have been reported; all but one were detected before the age of 25 years. In this report, we review the literature and describe what we believe to be only the second reported case of right ventricular outflow tract obstruction produced by a cardiac hemangioma that presented in late adulthood.- - - - - - - - - - ranking = 0.086223189651717keywords = hemangioma (Clic here for more details about this article) |
9/114. Rare presentation of cardiac hemangiomas.Cardiac hemangiomas are exceptionally rare tumors with an incidence of 1% to 2% of all detected benign heart neoplasms. The clinical appearance of the tumor varies considerably and may mimic other pathological findings of definite heart structures. We report two cases of cardiac hemangiomas presenting with an unusual location and clinical course.- - - - - - - - - - ranking = 0.25866956895515keywords = hemangioma (Clic here for more details about this article) |
10/114. decompression of fetal cardiac tamponade caused by congenital capillary hemangioma of the pericardium.BACKGROUND: Isolated fetal pericardial effusion is rare but has been associated with various cardiac masses. decompression in utero might prolong the pregnancy. CASE: In a 34-year-old white woman, gravida 3, para 0-1-1-1, at 34 5/7 weeks' gestation, ultrasound detected massive fetal pericardial effusion that progressed rapidly to hydrops. The fetal heart was structurally normal. We decompressed the fetal cardiac tamponade by pericardiocentesis, removing 52 mL of straw-colored fluid, which improved fetal movement and hydrops. We did pericardiocentesis at 6 weeks postpartum for a large pericardial effusion. Two weeks later the effusion recurred and we did thoracotomy with pericardial window placement. Pathologic diagnosis of pericardial biopsy was congenital capillary hemangioma of the pericardium. CONCLUSION: Isolated fetal pericardial effusion can be caused by capillary hemangioma of the pericardium despite lack of any mass on ultrasound. decompression of pericardial effusion in utero might relieve fetal cardiac tamponade and extend pregnancy.- - - - - - - - - - ranking = 0.25866956895515keywords = hemangioma (Clic here for more details about this article) |
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