1/14. Genetic detection and isolation of crimean-congo hemorrhagic fever virus, kosovo, yugoslavia.Crimean-congo hemorrhagic fever virus (C-CHFV) strains were isolated from a fatal case and the attending physician in kosovo, yugoslavia. Early, rapid diagnosis of the disease was achieved by reverse transcription-polymerase chain reaction. The physician was successfully treated with oral ribavirin. These cases yielded the first genetically studied C-CHFV human isolates in the Balkans.- - - - - - - - - - ranking = 1keywords = virus (Clic here for more details about this article) |
2/14. A patient with Crimean-congo hemorrhagic fever serologically diagnosed by recombinant nucleoprotein-based antibody detection systems.We treated a male patient with Crimean-congo hemorrhagic fever (CCHF). The diagnosis of CCHF was confirmed by reverse transcription-PCR and recombinant nucleoprotein (rNP)-based immunoglobulin g (IgG) and IgM capture enzyme-linked immunosorbent assays of serially collected serum samples. The patient was treated with intravenous ribavirin and recovered with no consequences. The study indicates that rNP-based CCHF virus antibody detection systems are useful for confirming CCHF virus infections. This case also suggests that intravenous ribavirin therapy may be promising for the treatment of CCHF patients.- - - - - - - - - - ranking = 0.4keywords = virus (Clic here for more details about this article) |
3/14. Possible horizontal transmission of crimean-congo hemorrhagic fever virus from a mother to her child.The case of a child with Crimean-congo hemorrhagic fever (CCHF) presumably infected with CCHF virus from her 27-year-old mother is described. The mother with CCHF was treated with ribavirin and did not present with any symptoms of obvious hemorrhage. The child developed fever on the 5th day after the mother's onset. The partial virus genome was amplified by RT-PCR, and nested PCR from the child and the genome sequence were identical to that from the mother, indicating possible transmission of the virus from mother to child. This case indicates the importance of preventive measures for in-house outbreaks of CCHF.- - - - - - - - - - ranking = 1.4keywords = virus (Clic here for more details about this article) |
4/14. Crimean-congo hemorrhagic fever, mauritania.From February to August 2003, 38 persons were infected with Crimean-congo hemorrhagic fever (CCHF) virus in mauritania; 35 of these persons were residents of Nouakchott. The first patient was a young woman who became ill shortly after butchering a goat. She transmitted the infection to 15 persons in the hospital where she was admitted and four members of her family. In Nouakchott, two disease clusters and 11 isolated cases were identified. The case-fatality ratio was 28.6%. Of the patients not infected by the first case-patient, almost half were butchers, which suggests that the primary mode of animal-to-human transmission was direct contact with blood of infected animals. The hospital outbreak alerted health authorities to sporadic cases that occurred in the following weeks, which would have probably gone otherwise unnoticed. Studies must be conducted to determine the potential risk for continued sporadic outbreaks of CCHF in humans and to propose prevention measures.- - - - - - - - - - ranking = 0.22104701401418keywords = virus, animal (Clic here for more details about this article) |
5/14. Crimean-congo hemorrhagic fever outbreak in Rawalpindi, pakistan, February 2002: contact tracing and risk assessment.A 25-year-old woman, later identified as index case of Crimean-congo hemorrhagic fever (CCHF), presented to Holy family Hospital in Rawalpindi, pakistan with fever and generalized coagulopathy. A retrospective contact tracing was conducted to explore the modes of exposure possibly associated with transmission of CCHF infection among contacts. We traced 32 contacts of the index case and 158 contacts of secondary cases and tested them for IgG and IgM antibodies against CCHF virus by an enzyme-linked immunosorbent assay technique. According to the type of exposure, contacts were divided into five subsets: percutaneous contact with blood, blood contact to unbroken skin, cutaneous contact to non-sanguineous body fluids, physical contact with patients without body fluids contact, and close proximity without touching. Two out of four contacts who reported percutaneous exposure tested positive for antibodies to CCHF virus. We conclude that simple barrier methods and care in provision of CCHF cases may prevent transmission of this infection.- - - - - - - - - - ranking = 0.4keywords = virus (Clic here for more details about this article) |
6/14. Crimean congo hemorrhagic fever infection simulating acute appendicitis.An unusual cause of acute abdominal pain simulating acute appendicitis is presented. The patient was admitted with complaints of fever, malaise, headache, nausea, vomiting, diarrhoea, and severe bleeding. Based on the clinical and epidemiological findings, a diagnosis of Crimean congo hemorrhagic fever virus infection was suspected, and ribavirin therapy was started. While her clinical condition was improving, she experienced a sudden pain at her right lower quadrant of the abdomen. Explorative laparotomy revealed haemorrhage within the abdominal muscles. Her CCHF IgM was found to be positive.- - - - - - - - - - ranking = 0.2keywords = virus (Clic here for more details about this article) |
7/14. Imported Crimean-congo hemorrhagic fever.Crimean-congo hemorrhagic fever (CCHF) is a tick-borne disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. Despite its wide geographic distribution in animals, CCHF virus is rarely associated with recognized human diseases. We report the first case of imported CCHF in france.- - - - - - - - - - ranking = 0.21052350700709keywords = virus, animal (Clic here for more details about this article) |
8/14. Crimean-congo hemorrhagic fever: case series from a medical center in Golestan province, Northeast of iran (2004).Crimean-congo hemorrhagic fever (CCHF) is a widely distributed lethal disease, worldwide. humans are usually infected with CCHF virus through a tick bite or close contact with viral contaminated tissues or with blood of domestic animals or of infected patients. The present study reports six cases of CCHF, who were in contact with both infected tissues and blood from sheep. In some regions like Golestan province (North of iran), clinician suspicion may have an important role in early diagnosis and treatment of the disease. Conservative therapy (intensive monitoring) and prescription of antiviral medication (ribavirin) accompanied with corticosteroids, was useful at the early stage of CCHF.- - - - - - - - - - ranking = 0.21052350700709keywords = virus, animal (Clic here for more details about this article) |
9/14. A common-source outbreak of Crimean-congo haemorrhagic fever on a dairy farm.An outbreak of Crimean-congo haemorrhagic fever (CCHF) on a dairy farm in the Orange Free State in 1984 is described. Forty-six cows were purchased from the western Cape Province in January 1984; 2 died from the tick-borne disease anaplasmosis in March and a labourer who helped butcher the carcasses became ill a few days later. Another cow died at the end of April and within 9 days 4 people who had come into contact with its blood became ill. antibodies to CCHF virus were found in the sera of the 5 patients but not in other residents of the farm. Three patients recovered from a severe influenza-like illness without seeking medical attention; 1 patient, who was admitted to hospital, recovered from illness marked by haematemesis, epistaxis and amnesia and the 5th patient died of complications of surgery for brain haemorrhage. Antibody studies indicated that many of the cows became infected with CCHF after their arrival on the farm. It can be deduced that animals reared in tick-free, or relatively tick-free, circumstances, which are then moved to where they are subject to heavy parasitization by ticks, can acquire common tick-borne diseases of livestock plus CCHF infection simultaneously. In such circumstances there is a definite risk of human exposure to CCHF-infected blood or other tissues.- - - - - - - - - - ranking = 0.21052350700709keywords = virus, animal (Clic here for more details about this article) |
10/14. Investigations following initial recognition of Crimean-congo haemorrhagic fever in south africa and the diagnosis of 2 further cases.Sera from 124 cattle herds were tested, and antibodies to Crimean-congo haemorrhagic fever (CCHF) were found in 93 herds. The prevalence of antibodies was high in the interior of the country, in excess of 90% in some herds, but was less than 4% in cattle along the coast from Cape Town to East london. Only 17 out of 1109 (1,5%) human residents of 55 farms had antibodies to CCHF, while none of 164 veterinary research workers or 98 veterinarians engaged in farm animal practice had them. Specimens from 130 suspected cases of viral haemorrhagic fever were examined and CCHF was diagnosed only in the patient previously reported as the first case of the disease to be recognized in this country. A further 2 cases of CCHF were diagnosed by examining 318 specimens from patients with nonfatal febrile illness. Both patients had contact with livestock. Increasing awareness of the disease will probably lead to an increase in the number of cases diagnosed, but there are no grounds for concluding that the disease is on the increase.- - - - - - - - - - ranking = 0.01052350700709keywords = animal (Clic here for more details about this article) |
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