1/11. Persisting hiv-1 replication triggered by acute hepatitis a virus infection.We report the case of two patients in whom acute hepatitis A was associated with a marked and prolonged increase in human immunodeficiency virus type 1 (hiv-1) viral load. Although in one patient the rise in hiv-1 rna might also have been related to the interruption of antiretroviral therapy, we also observed a similar pattern in the other patient who had a stable undetectable plasma viraemia prior to acute hepatitis and never received treatment with anti-retrovirals. Our observation supports the hypothesis that immune activation that is induced by acute hepatitis a virus (HAV) infection may trigger hiv-1 replication. This highlights the importance of maintaining antiretroviral therapy throughout the acute phase of hepatitis A and of preventing HAV infection through active immunization.- - - - - - - - - - ranking = 1keywords = deficiency (Clic here for more details about this article) |
2/11. Prolonged hepatitis A infection in an hiv-1 seropositive patient.hepatitis a virus (HAV) is a worldwide disease; in most cases, it causes an acute self-limited illness that does not lead to a chronic state. The course of HAV viremia in a homosexual male with human immunodeficiency virus type 1 (hiv-1) and the correlation between HIV and HAV viral load, alanine aminotranferase (ALT) level, and CD4( ) lymphocyte count were investigated during the course of the infection. HAV rna was detected quantitatively up to 256 days after clinical onset. To our knowledge, this specific case is the first report of a prolonged infection with hepatitis A in a male with hiv-1. The ALT levels decreased gradually; however, 286 days after clinical onset of hepatitis, ALT levels were three times higher than normal values. HIV viral load was not affected by the infection with HAV and CD4( ) cell count was stable during the course of the co-infection. The duration and the high-titer viremia of hepatitis a virus in an immunodeficient patient constitute a serious risk of the spread of hepatitis A within this population. As inactivated HAV vaccine is safe in HIV-positive subjects, it would be wise to establish a strategy of preventive vaccination in this high-risk group.- - - - - - - - - - ranking = 1keywords = deficiency (Clic here for more details about this article) |
3/11. Severe haemolysis associated with hepatitis A and normal glucose-6-phosphate dehydrogenase status.We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency.- - - - - - - - - - ranking = 196.35303367083keywords = dehydrogenase deficiency, dehydrogenase, deficiency (Clic here for more details about this article) |
4/11. Hepatoerythropoietic porphyria precipitated by viral hepatitis.porphyria cutanea tarda (PCT), the condition resulting from a deficiency of hepatic uroporphyrinogen decarboxylase activity, is the commonest form of porphyria. Both acquired and familial form exist and are commonly associated in adults with liver disease and hepatic iron overload. The condition is extremely rare in children; most cases of childhood PCT are familial and some particularly severe cases have been shown to have a hepatoerythropoietic porphyria or homozygous uroporphyrinogen decarboxylase deficiency. A case is described of hepatoerythropoietic porphyria in which the disease was first precipitated at the age of two by a coincidental hepatitis A infection and improved as the hepatitis cleared. This paper reviews the evidence that viral hepatitis may precipitate overt PCT in children in a manner analogous to the precipitation of PCT in adults by alcohol associated liver disease.- - - - - - - - - - ranking = 2keywords = deficiency (Clic here for more details about this article) |
5/11. hyperbilirubinemia following hepatitis A in a patient with G6pD deficiency.A case of viral hepatitis A with G6PD deficiency is described. The condition should be suspected in the presence of indirect hyperbilirubinemia, and anemia in a patient with viral hepatitis; repeat G6PD testing 8 weeks later is recommended for diagnosis.- - - - - - - - - - ranking = 5keywords = deficiency (Clic here for more details about this article) |
6/11. Acute viral hepatitis, glucose-6-phosphate dehydrogenase deficiency and prolonged acute renal failure: a case report.A 10-year-old boy with glucose-6-phosphate dehydrogenase deficiency developed acute renal failure during the icteric phase of non-fulminant hepatitis A infection. He needed peritoneal dialysis for 54 days. Acute tubular necrosis was confirmed by percutaneous renal biopsy. He had complete recovery of his renal function when he was discharged.- - - - - - - - - - ranking = 825.82660819448keywords = dehydrogenase deficiency, dehydrogenase, deficiency (Clic here for more details about this article) |
7/11. Severe hyperbilirubinemia due to acute hepatitis A superimposed on a chronic hepatitis b carrier with glucose-6-phosphate dehydrogenase deficiency.taiwan is an endemic area for hepatitis A and B virus infections; nearly 90% of adults have serological markers for either virus. glucose-6-phosphate dehydrogenase (G6PD) deficiency is also common, ranging from 2% to 10%. We report the case of a 36-yr-old chronic HBV male carrier with G6PD deficiency who developed acute viral hepatitis A with severe hyperbilirubinemia and intravascular hemolysis. The hemolysis was in all likelihood the result of recent exposure to sulfa drugs. Fulminant hepatitis was the initial impression, because the peak serum total bilirubin concentration was alarmingly high, at 85.4 mg/dl. Exchange plasmapheresis was fresh frozen plasma was performed, and various laboratory studies gradually returned to near normal laboratory studies gradually returned to near normal over the next 3 wk. The patient made an uneventful recovery 1 month after admission.- - - - - - - - - - ranking = 670.45821456356keywords = dehydrogenase deficiency, dehydrogenase, deficiency (Clic here for more details about this article) |
8/11. Infectious hepatitis and glucose-6-phosphate dehydrogenase deficiency.The occurrence of infectious hepatitis in patients with coexistent glucose-6-phosphate dehydrogenase (G6PD) deficiency may present a clinical picture similar to that of fulminant hepatitis. To determine the factors which enable a rapid diagnosis of this disease combination, the clinical and biochemical findings in 14 patients were compared with those in 50 patients with uncomplicated hepatitis and those in 14 patients with fulminant hepatitis. Similarities with the latter group included persistence of fever, tachycardia, leukocytosis and hyperbilirubinemia of greater than 340 mumol/liter (20 mg/dl). A rise in bilirubin values of more than 50 mumol/liter (3 mg/dl) per day in patients with viral hepatitis strongly suggested the presence of G6PD deficiency. Despite the severity of the illness, prothrombin activity was well maintained in G6PD-deficienct patients.- - - - - - - - - - ranking = 670.45821456356keywords = dehydrogenase deficiency, dehydrogenase, deficiency (Clic here for more details about this article) |
9/11. Coombs-negative severe hemolysis associated with hepatitis A.Mild anemia can occasionally be observed during viral hepatitis, but severe hemolysis has previously only been reported in a few patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a case of massive acute hemolysis associated with an acute hepatitis A in a 39-year-old woman in the absence of G6PD-deficiency. The patient was also suffering from mild rheumatoid arthritis. All known factors responsible for hemolysis were ruled out. Although tests for autoimmune hemolytic anemia were negative the patient made a dramatic recovery after treatment with corticosteroids, suggesting an immune mediated mechanism nonetheless.- - - - - - - - - - ranking = 9.7969280079839keywords = dehydrogenase, deficiency (Clic here for more details about this article) |
10/11. Hepatitis A and cytomegalovirus infection precipitating acute hemolysis in glucose-6-phosphate dehydrogenase deficiency.A 34-year-old man presented with acute hemolytic anemia secondary to acute viral hepatitis A and a coexisting acute cytomegalovirus infection. This association has not been described previously in patients with glucose-6-phosphate dehydrogenase deficiency and is the subject of this report.- - - - - - - - - - ranking = 825.82660819448keywords = dehydrogenase deficiency, dehydrogenase, deficiency (Clic here for more details about this article) |
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