1/11. Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa.hidradenitis suppurativa is a chronic inflammatory disease of the sweat glands and hair follicles which is rarely associated with squamous cell carcinoma (SCC). A case of vulval SCC complicating hidradenitis suppurativa is presented. In addition to being the first case to report the association of vulval SCC and hidradenitis suppurativa in the English language literature, it also illustrates the difficulty inherent in distinguishing between invasive SCC and pseudoepitheliomatous hyperplasia on histological examination. The success of wide local excision of the vulval lesion and primary closure without recourse to skin grafts, rotational flaps, or healing by secondary intention is demonstrated.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
2/11. hidradenitis suppurativa polyposa.A case of severe chronic hidradenitis suppurativa of the perineum complicated by disfiguring fibrous, polypoid lesions is presented. The patient, a 41-year-old woman, had a long history of axillary hidradenitis which subsequently involved the perineum. Draining sinuses, scars and large pendulous masses of the vulva developed over 10 years. Cutaneous scars, ridges, papules and large fibrous polyps were present. Deep clefts, sinuses, dense fibrous scars and foci of chronic inflammation were seen. Rarely, large fibrous polyps may develop in chronic hidradenitis suppurativa and may be due to chronic local lymphedema. Careful pathologic examination is necessary to exclude squamous cell carcinoma.- - - - - - - - - - ranking = 0.2keywords = carcinoma (Clic here for more details about this article) |
3/11. Verrucous carcinoma arising in hidradenitis suppurativa.There are many reported cases of squamous carcinoma complicating hidradenitis suppurativa, but only one previous mention of verrucous carcinoma in this setting. We describe a case of verrucous carcinoma arising in hidradenitis suppurativa of the anal margin in a non-immunosuppressed man. This is the second report of verrucous carcinoma arising in a lesion of hidradenitis suppurativa. Although hidradenitis suppurativa can involve multiple intertriginous sites, malignant degeneration occurs mostly in the anogenital region. This suggests a role for a regional factor which, when combined with chronic inflammation, predisposes to malignant degeneration. A likely candidate for this factor is human papillomavirus; our case showed histologic evidence for this, but the specimen did not show viral dna by polymerase chain reaction in situ hybridization. The ability of anogenital hidradenitis suppurativa to form squamous and verrucous cancers reinforces the argument for early and complete resection.- - - - - - - - - - ranking = 1.6keywords = carcinoma (Clic here for more details about this article) |
4/11. Negative-pressure dressings in the treatment of hidradenitis suppurativa.Negative-pressure dressings have been used in the treatment of a variety of open wounds, and as a bolster for skin grafts. The benefits of these dressings include increased oxygen tension in the wound, decreased bacterial counts, increased granulation formation, and the prevention of shear force on wounds. Also, by virtue of the diminished need for daily dressing changes, there are the additional advantages of enhancing patient comfort, decreasing nursing work, and diminished cost of wound care. hidradenitis suppurativa (HS) is a chronic infection of the apocrine sweat glands. Treatment options range from oral isotretinoin to radical excision. Wound closure may be achieved by secondary intention, skin grafting, or flap closure. Complications may still arise and include disease progression and squamous cell carcinoma. Radical excision yields the best results in terms of disease eradication. The authors describe using the negative-pressure dressing in two cases of bilateral axillary HS to secure skin grafts firmly to the wound bed after radical excision of all involved tissues. Patient comfort and acceptance was high, and skin graft take was excellent. The dressings themselves are simple to apply and are highly effective.- - - - - - - - - - ranking = 0.2keywords = carcinoma (Clic here for more details about this article) |
5/11. hidradenitis suppurativa and squamous cell carcinoma.BACKGROUND: hidradenitis suppurativa is a recurrent, chronic inflammatory disease with complications such as abscesses and sinus tract formations, fistulization, and scarring. Squamous cell carcinoma is rare, and is the most serious complication. OBJECTIVE: To present the evolution of squamous cell carcinoma in long-term hidradenitis suppurativa. methods: Case report and literature review. CONCLUSION: Many conservative therapies have no or minimal effect in perineal hidradenitis suppurativa. Therefore surgical excision must be considered in the early stages of the disease at this region to prevent further complications.- - - - - - - - - - ranking = 1.2keywords = carcinoma (Clic here for more details about this article) |
6/11. hidradenitis suppurativa complicated by squamous cell carcinoma and paraneoplastic neuropathy.Squamous cell carcinoma is a rare complication of chronic, severe, hidradenitis suppurativa. We describe a patient with a 20-year history of extensive perineal hidradenitis suppurativa who presented with subacute muscle weakness and sensory symptoms. He was subsequently diagnosed with squamous cell carcinoma arising in the area of hidradenitis. The neurologic symptoms and signs resolved after complete excision of the tumor. This presentation is consistent with a paraneoplastic neuropathy, which has not been reported previously in patients with squamous cell carcinoma arising in patients with hidradenitis suppurativa.- - - - - - - - - - ranking = 1.4keywords = carcinoma (Clic here for more details about this article) |
7/11. Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa.We report a case of vulval squamous cell carcinoma (SCC) arising in chronic hidradenitis suppurativa (HS). The patient had a complex medical history including a 25-year-history of Crohn's disease. In addition she had recently received immunosuppressive therapy for nephrotic syndrome secondary to membranous glomerulonephritis. A painful nodule was noted on the vulva that was clinically very suspicious of SCC. An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. We suggest constant vigilance with regard to malignant change in ano-genital HS as the diagnosis can be difficult.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
8/11. A case of squamous cell carcinoma complicating hidradenitis suppurativa.A case of extensive squamous cell carcinoma arising in widespread perianal and inguinal hidradenitis suppurativa is used to illustrate the pathological features which influence management. The surgical pathology, with wide extension along subcutaneous sinuses, frequently leads to the view that it is incurable. A planned surgical approach, using both immediate frozen section and delayed paraffin histology to assess clearance margins allowed complete surgical excision in two stages. colostomy is not a necessary part of management and healing by granulation is an acceptable alternative to extensive reconstruction procedures. radiotherapy and chemotherapy, sometimes used in palliation mode, are not likely to be beneficial.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
9/11. Elevated parathyroid hormone-related protein and hypercalcemia in a patient with cutaneous squamous cell carcinoma complicating hidradenitis suppurativa.We have described the case of a patient with long-standing hidradenitis suppurativa in whom associated cutaneous squamous cell carcinoma developed; this was complicated by hypercalcemia. serum PTH-RP levels were elevated to 14.8 pmol/L. This is the third case report of hypercalcemia associated with squamous cell carcinoma complicating hidradenitis suppurativa and the first in which an elevated serum PTH-RP level has been documented in cutaneous squamous cell carcinoma.- - - - - - - - - - ranking = 1.4keywords = carcinoma (Clic here for more details about this article) |
10/11. Squamous cell carcinoma complicating perianal hidradenitis suppurativa.hidradenitis suppurativa or Verneuil's disease is usually a chronic, recurrent, suppurative and cicatricial disorder. It most often affects the skin of the axillae, groins and perineum, and less commonly the buttocks and upper thighs. A squamous cell carcinoma located in the hidradenitis-affected area is a rare complication. We present a review of the twenty-six published cases adding one of our own.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
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