1/3. Characteristics of pyridoxine overdose neuropathy syndrome.A newly recognised neurotoxic syndrome due to pyridoxine (B6) overdose is described. It is the largest series of B6 intoxication hitherto reported. A raised serum B6 level was present in 172 women of whom 60% had neurological symptoms, which disappeared when B6 was withdrawn and reappeared in 4 cases when B6 was restarted. The mean dose of B6 in the 103 women with neurological symptoms was 117 /- 92 mgs, compared with 116.2 /- 66 mgs in the control group. There was a significant difference (P less than 0.01) in the average duration of ingestion of B6 in the neurotoxic group of 2.9 /- 1.9 years compared with 1.6 /- 2.1 years in controls. The symptoms were paraesthesia, hyperaesthesia, bone pains, muscle weakness, numbness and fasciculation, most marked on the extremities and predominantly bilateral unless there was a history of previous trauma to the limb. These women were taking a lower dose of B6 than previously described (1,2), which may account for the complete recovery within 6 months of stopping B6.- - - - - - - - - - ranking = 1keywords = paraesthesia (Clic here for more details about this article) |
2/3. Urological complications following chemonucleolysis.Urinary complications following chemonucleolysis have not been reported in the urological literature. We report a case of urinary retention, perineal hypoesthesia and penile dysesthesia following L5 to S1 chemonucleolysis with chymopapain and review the literature in this area.- - - - - - - - - - ranking = 72.447809626825keywords = dysesthesia (Clic here for more details about this article) |
3/3. strychnine poisoning: natural course of a nonfatal case.A rare case of suicidal strychnine poisoning that resolved naturally without treatment is presented. The patient first complained of chest pain, which was originally thought to be caused by a dissecting aneurysm; however, nystagmus, dysesthesia, spastic paraplesia, and hyperreactivity to stimuli shortly developed. diagnosis was difficult because the patient did not disclose the drinking of strychnine or the suicidal intent, and no abnormal signs were seen in the various central nervous system examinations. The natural course was observed without treatment because the patient's circulatory and respiratory condition was good. movement disturbances in the upper extremities disappeared after 2 days, nystagmus in 3 days, and dysesthesia and spastic paraplesia in 4 days. The patient was able to stand on the fourth day and walk on the seventh. He was discharged on day 10 without any detectable ill effects.- - - - - - - - - - ranking = 144.89561925365keywords = dysesthesia (Clic here for more details about this article) |