1/12. Brown tumour of hyperparathyroidism in the mandible associated with atypical parathyroid adenoma.The brown tumour of hyperparathyroidism is a localized bone tumour and an uncommon manifestation of hyperparathyroidism. A 27-year-old woman presented with a mandibular 8 x 10 cm solid mass diagnosed as central giant cell granuloma. Chemical blood analysis revealed increased serum calcium levels of 12.46 mg/dL and the parathyroid hormone level was 124 pg/dL. The patient underwent surgery with removal of a parathyroid mass. Histologically, this parathyroid tissue was seen to be limited by a fibrous capsule with morphological features consistent with atypical parathyroid adenoma. The mandibular tumour has receded and the patient declined further procedures. This is the first case reported of brown tumour as the primary manifestation of an atypical parathyroid adenoma, a lesion that shares some features with parathyroid carcinoma without the unequivocal properties of malignancy.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/12. Brown tumor of the thoracic spine in a patient on long-term hemodialysis.A 39-year-old woman on long-term hemodialysis presented with a history of rapidly progressive paraplegia. Radiological examination showed a compression fracture of seventh thoracic vertebra and expansive mass lesion in the posterior elements of the fourth thoracic vertebra. Laboratory tests on admission showed serum calcium of 11.9 mg/dl, phosphate 6.0 mg/dl, and the high-sensitive parathyroid hormone level of 139,191 pg/ml measured by radioimmunoassay. Percutaneous biopsy of the expansive mass showed a large number of multinucleated giant cells in a fibroblastic stroma containing abundant hemosiderin. Tumor resection and anterior interbody fusion with artificial bone graft was performed on 14th hospital day. paraplegia gradually improved postoperatively. Total parathyroidectomy and autotransplantation of parathyroid gland were subsequently performed. Nodular hyperplasia was evident in the parathyroid glands by light microscopy. Brown tumor is rarely found in vertebral bone and this is the sixth case of such tumor in secondary hyperparathyroidism.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
3/12. Giant cell lesion of the mandible in coincidental hyperparathyroidism and hyperthyroidism.A patient with hyperparathyroidism, thyrotoxicosis and a giant cell lesion of the mandible is reported. The hyperparathyroidism was secondary to renal hypoplasia and/or thyrotoxicosis. A review of the literature revealed other cases with giant cell lesions and secondary hyperparathyroidism. This study indicates that giant cell lesions are not specific for primary hyperparathyroidism.- - - - - - - - - - ranking = 3keywords = giant (Clic here for more details about this article) |
4/12. Central giant cell granuloma.Central giant cell granuloma, a fibro-osseous lesion, is more commonly found in the mandible and mainly in children and young adults. The lesion, which has a greater incidence in females, may be uni or multilocular. On the basis of clinical, radiological and histologic features, central giant cell granulomas can be classified as "non-aggressive" or "aggressive". Management involves surgical removal and in most cases the dentition can be maintained. Three cases of central giant cell granuloma are reported and they illustrate clinical features of the lesion, how differential diagnosis can be assisted by ORAD (a special software program), treatment, and the importance of recall examinations.- - - - - - - - - - ranking = 7keywords = giant (Clic here for more details about this article) |
5/12. Vertebral localization of a brown tumor: description of a case and review of the literature.The authors report a case of a female aged 45 years submitted to a long period of hemodialysis, affected with brown tumor of the lumbar spine. Brown tumor must be taken into consideration in the differential diagnosis of osteolytic lesions of the skeleton, particularly in young, nephropathic women undergoing hemodialysis. Brown tumor has a more favorable prognosis as compared to other lesions that have similar clinical and radiographic findings, such as metastatic lesions and giant cell tumors. In the case of brown tumor, in addition to treating lesion of the spine, treatment varying depending on neurological findings and biomechanical complications (structural collapse, segmental kyphosis, pathologic fracture, etc.), removal of the parathyroids and correction of the metabolic alterations is indispensable.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
6/12. Fluorosis-induced hyperparathyroidism mimicking a giant-cell tumour of the femur.We report the case of a young woman who, over a period of five years was diagnosed and treated for a giant-cell tumour of bone, osteomalacia and fluorosis. A review of the literature revealed a correlation between these three diagnoses, the primary pathology being fluorosis and the remaining symptoms being secondary manifestations. It is important to be aware of this association, especially in regions with endemic skeletal fluorosis.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
7/12. diagnosis of a maxillary brown tumor associated with hyperparathyroidism secondary to chronic renal failure--a case report.Brown tumor associated with hyperparathyroidism secondary to chronic renal failure has been increasingly documented of late. This intraosseous giant cell lesion is indistinguishable from a central giant cell granuloma and is considered as an unusual local complication of renal osteodystrophy. This report presents a case of a maxillary brown tumor in an uremic, non-hemodialysis patient with secondary hyperparathyroidism. The radiographic, biochemical, and histopathological examinations are reported and the possible pathogenesis is also discussed.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
8/12. Brown tumor of secondary hyperparathyroidism involving the superior orbit and frontal calvarium.A 29-year-old white man with chronic renal failure on hemodialysis presented with a subacute onset of painful proptosis, inferior displacement and limited upgaze of his right globe, and a tender, palpable fronto-temporal mass beneath the right scalp. A cranio-orbitotomy was performed to completely excise a large, necrotic, multilocular, cystic, heterogeneous mass. Histopathologic examination with light microscopy demonstrated the characteristic findings of a giant cell tumor. Based on the patient's history of renal failure and laboratory evidence of hyperparathyroidism, a diagnosis of brown tumor was determined.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
9/12. Giant cell lesion associated with secondary hyperparathyroidism: case report.A child with a giant cell lesion (brown tumor) associated with secondary hyperparathyroidism due to chronic renal failure was reported. The patient presented at age 6 years, 5 months with swelling in the right mandible that was biopsied and diagnosed histologically as a giant cell lesion. The patient received a successful kidney transplant 8 months later and the giant cell lesion resolved during the 17 months following the operation.- - - - - - - - - - ranking = 3keywords = giant (Clic here for more details about this article) |
10/12. Secondary hyperparathyroidism combined with uremia and giant cell containing tumor of the cervical spine. A case report.A 47-year-old woman with chronic pyelonephritis since 1950 was prepared for hemodialysis or kidney transplantation. Investigation disclosed secondary hyperparathyroidism and an osteolytic lesion in C VII and Th I causing a subluxation. There were minor neurological symptoms and apparent risk of luxation of the cervical spine with resulting injury to the spinal cord. Operation was performed with total parathyroidectomy and excision of the bone tumor, followed by fixation of the cervical spine with bone graft. There were no major complications during the postoperative period and the patient was mobilized four months after the operation.- - - - - - - - - - ranking = 4keywords = giant (Clic here for more details about this article) |
| | Next -> |