1/3. Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero.Fetal valproate syndrome results from in utero exposure to valproic acid. It is characterized by a distinctive facial appearence, a cluster of minor and major anomalies, and central nervous system dysfunction. We report on a child exposed prenatally to valproic acid with unusual anomalies. This patient was the first child of young parents. Mother had several generalized seizures one year before this pregnancy, and since than she took valproic acid. pregnancy was otherwise uneventful. At birth physical examination showed generalized hypertrichosis sparing palms and soles, coarse face, gum hypertrophy, hypotonia, club feet and club hands, two annular constrictions of the right lower leg, and abnormal dermatoglyphics. Skeletal x-rays were normal. Gum hypertrophy and hypertrichosis may be part of a broader pattern of altered morphogenesis in fetus exposed to valproic acid or this patient had two conditions, fetal valproate syndrome and hypertrichosis with gum fibromatosis.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
2/3. Congenital hypertrichosis universalis.Congenital hypertrichosis universalis is a rare familial disorder felt to be inherited as an autosomal dominant trait. The patient described below was noted to have excessive body hair at birth. The hairiness increased progressively. By two years of age, the patient's face, trunk and limbs were covered with long hair. Only the mucous membranes, palms and soles were spared. The patient's father and paternal grandfather were also noted to be hirsute at birth.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
3/3. Acquired hypertrichosis lanuginosa. Rare manifestation of urinary bladder carcinoma.hypertrichosis lanuginosa developed in a patient with carcinoma of the bladder. After regional lymph node metastases became evident, soft, fine, blond hair developed on his entire body, with the exception of the soles and the palms. Extensive endocrinologic evaluation demonstrated depressed testosterone levels and elevated levels of leutinizing hormone, changes not thought to be related to the hair growth. To our knowledge, this patient constitutes the second reported case of this rare syndrome in association with bladder carcinoma.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |