1/55. Extraosseous metastases of hepatocellular carcinoma detection and therapeutic assessment with Tc-99m PMT SPECT.Owing to recent advances in imaging technology and radiologic intervention, survival rates in patients with hepatocellular carcinoma have improved markedly. However, such prolonged survival has resulted in an increase in extrahepatic metastases. Tc-99m (Sn)-N-pyridoxyl-5-methyltryptophan (Tc-99m PMT), developed for hepatobiliary scintigraphy, has been used to visualize extrahepatic metastases, with most related reports limited to osseous metastases. The authors report two cases of hepatocellular cancer presenting as a hypopharyngeal metastasis and intraperitoneal dissemination along the tract of a fine-needle biopsy. Lesions undetectable on planar imaging could be visualized by Tc-99m PMT SPECT.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
2/55. Primary placement of a voice prosthesis on transposed colon after total pharyngolaryngoesophagectomy.BACKGROUND: Primary placement of a voice prosthesis may aid rehabilitation after total laryngectomy. methods: We present a rare clinical situation of a T4 NO MO squamous cell carcinoma of the hypopharynx and esophagus in a patient who had previously undergone a transmesocolic Billroth II gastrectomy. RESULTS: The patient benefited from a total pharyngolaryngoesophagectomy, with reconstruction using a transverse-descending colon transposition, and primary placement of a low-pressure voice prosthesis. CONCLUSION: Primary placement of a voice prosthesis may be successful even in a patient who requires extensive pharyngoesophageal reconstruction using transposed colon. To our knowledge, there has been no previous report of primary placement of a voice prosthesis on a colon autograft.- - - - - - - - - - ranking = 0.2keywords = carcinoma (Clic here for more details about this article) |
3/55. Minimally invasive surgery for recurrent neuroendocrine carcinoma of the supraglottic larynx.calcitonin-secreting neuroendocrine carcinomas of the supraglottic larynx are infrequent tumors, making it difficult to agree on treatment plans for recurrent tumors. Furthermore, this rare malignancy is often confused with the more common medullary thyroid carcinoma, resulting in inappropriate thyroidectomies. We present a case report of a calcitonin-secreting recurrent neuroendocrine carcinoma of the supraglottic larynx, in which surgery and pentagastrin stimulation were performed repeatedly at various stages of the disease. The recurrent laryngeal tumor was ultimately identified and, after construction of a protective tracheostomy, resected transorally en bloc with the underlying arytenoid cartilage. Postoperatively, the patient did well and stimulated calcitonin levels never exceeded double baseline values. Laryngoscopic removal of smaller laryngeal carcinomas is both technically feasible and safe, even when tumors are recurrent. In calcitonin-secreting malignancies, pentagastrin stimulation may facilitate the distinction between laryngeal and medullary thyroid carcinoma and thus help avoid unnecessary thyroidectomies.- - - - - - - - - - ranking = 1.8keywords = carcinoma (Clic here for more details about this article) |
4/55. Choroidal metastasis from carcinoma of the hypopharynx: a case report.Choroidal metastasis from primaries other than breast or lung cancer is a rare event. There is no documented case in the literature of choroidal metastases in patients with hypopharynx carcinoma. Early treatment with radiation therapy provides effective palliation by preserving visual function and preventing the need for enucleation. Chemotherapy alone does not seem to be as effective as radiation therapy for patients with choroidal metastases. In this paper a case of choroidal metastasis arising from a primary hypopharynx carcinoma is presented.- - - - - - - - - - ranking = 1.2keywords = carcinoma (Clic here for more details about this article) |
5/55. cytomegalovirus colitis after administration of docetaxel-5-fluorouracil-cisplatin chemotherapy for locally advanced hypopharyngeal cancer.We present the case of a patient with a locally advanced hypopharyngeal carcinoma who developed a severe cytomegalovirus (CMV) colitis after his first chemotherapy course with 5-fluorouracil (5-FU), docetaxel and cisplatin. The most probable cause of his CMV colitis is the impaired immunity during a phase of neutropenia after the chemotherapy. Although there was amelioration of the colitis and clinical status after treatment with ganciclovir, the patient later deteriorated and died due to recurrent bacterial infections. This is the third reported case of CMV colitis treated with ganciclovir in a patient with a solid tumour. It is the first report of CMV colitis after docetaxel containing chemotherapy. Although CMV colitis is most frequently observed in immunosuppressed patients such as those with acquired immune deficiency syndrome (AIDS), transplants and corticosteroid treatment, it has also been reported in less immunosuppressed (elderly, malnourished,...) and even non-immunosuppressed patients. CMV infection should therefore be included in the differential diagnosis of GI disease in all patients, and when suspected, the clinician should pursue appropriate diagnostic and therapeutic interventions.- - - - - - - - - - ranking = 0.2keywords = carcinoma (Clic here for more details about this article) |
6/55. Free colon transfer for pharyngo-oesophageal reconstruction.This report describes free transfer of transverse colon for reconstruction of the hypopharynx and cervical oesophagus. The transverse colon based on the middle colic vessels was used in three patients following laryngo-pharyngo-oesophagectomy for hypopharyngeal squamous carcinoma. There were no flap failures or intra-abdominal complications. Solid diet was well tolerated. Transverse colon is easy to harvest, has a long vascular pedicle, wide diameter and good ischaemic tolerance. Contrast studies showed it to be a wide bore passive conduit. Compared with currently available options these features may allow better outcome in pharyngo-oesophageal reconstruction and warrant further evaluation.- - - - - - - - - - ranking = 0.2keywords = carcinoma (Clic here for more details about this article) |
7/55. granular cell tumor of the hypopharynx treated by endoscopic CO(2) laser excision: report of two cases.BACKGROUND: granular cell tumor (GCT), or Abrikossoff's tumor, is an unusual lesion probably arising from schwann cells. It is frequently found in the head and neck region, where the tongue is the most commonly affected site. Involvement of the hypopharynx is exceedingly rare because, to the best of our knowledge, only four cases have been reported in the literature. methods: We describe hypopharyngeal GCT in two women aged 29 and 52 years, respectively. RESULTS: In the first patient, preoperative diagnostic examination, including endoscopy, CT, and MRI scan, was suggestive of a benign lesion arising from the posterior wall of the hypopharynx. In the second patient, a previous biopsy of the postcricoid area performed elsewhere suggested a diagnosis of well-differentiated squamous cell carcinoma, and CT scan staged the lesion as T1 N0. In both cases, treatment included surgical excision under microlaryngoscopy with CO(2) laser. The histopathologic study of the specimens, supported by immunohistochemical techniques, determined the lesions to be a GCT. The postoperative course was uneventful, and the patients were discharged 12 and 2 days after surgery, respectively. Both patients were asymptomatic without evidence of recurrence when last seen 2 years and 4 months after surgery, respectively. CONCLUSIONS: GCT should be included in the differential diagnosis of submucosal hypopharyngeal lesions. endoscopy and radiologic imaging do not display any typical finding suggestive of the diagnosis, which can be based only on histologic findings. Resection of the tumor, when technically feasible, should be performed under microlaryngoscopy with the CO(2) laser, which makes it possible to work in a bloodless field with minimal thermal damage and reduction of scarring and postoperative edema.- - - - - - - - - - ranking = 0.2keywords = carcinoma (Clic here for more details about this article) |
8/55. Rapidly progressive glomerulonephritis and carcinoma of the hypopharynx.We report on a 50-year-old man with rapidly progressive glomerulonephritis and carcinoma of the hypopharynx. Because cancer treatment was followed by remission of proteinuria and complete restoration of renal function, a causal relationship between tumor and glomerular injury seems possible.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
9/55. Intracranial metastases in patients with squamous cell carcinoma of the head and neck.BACKGROUND: Intracranial metastases are rarely clinically diagnosed in patients with head and neck squamous cell carcinoma. Only 7 patients with metastases to the cavernous sinus from head and neck squamous cell carcinomas have been reported. methods: A retrospective study revealed 13 patients with intracranial metastases of head and neck squamous cell carcinoma. In a 53-year-old woman a cavernous sinus metastasis of a laryngeal carcinoma was histologically diagnosed by using a CT-guided surgical navigation system and was treated with stereotactic radiotherapy. RESULTS: The mean survival was 4.3 months. Predictive factors for longer survival were absence of extracranial disease, age younger than 60 years, and treatment with radiotherapy. CONCLUSIONS: The prognosis for patients with intracranial disease is poor. The current development of computer-assisted stereotactic navigation and stereotactic radiotherapy may facilitate surgical diagnostic exploration and improve treatment, especially in patients without extracranial disease.- - - - - - - - - - ranking = 1.6keywords = carcinoma (Clic here for more details about this article) |
10/55. Clinical studies of immunohistochemical staining of dna-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.PURPOSE: dna-dependent protein kinase (dna-PK), a serine/threonine kinase composed of p470 catalytic subunit (dna-PKcs) and p85/p70 heterodimer (Ku antigen), is considered a critical enzyme in the repair of the dna double-strand breaks (DSB) that are the major lethal lesions induced by ionizing radiation. We investigated the expression of dna-PK subunits in human tumors. MATERIALS AND methods: We examined immunohistochemically the biopsy specimens of 44 patients with oropharyngeal carcinoma and 32 patients with hypopharyngeal carcinoma who had been treated with radiotherapy. RESULTS: Immunopositivity to Ku85 and dna-PKcs was found in all patients. The staining of Ku85 and dna-PKcs was nuclear, with none of the normal epithelial cells or malignant cells exhibiting cytoplasmic or membrane immunoreactivity. Normal epithelial cells were all stained intensely. In tumors, intense nuclear staining of dna-PKcs was seen in 75 of 76 tumors, while that of Ku85 was seen in all 76 patients. The radiation responses of a primary tumor that was stained weakly with dna-PKcs were excellent. CONCLUSION: Our results suggest the possibility of predicting the intrinsic radiosensitivity of human tumors in clinics able to perform immunohistochemical analysis of dna-PK.- - - - - - - - - - ranking = 1.2keywords = carcinoma (Clic here for more details about this article) |
| | Next -> |