1/14. Spontaneous regression associated with apoptosis in a patient with acute-type adult T-cell leukemia.We describe a 76-year-old man with acute-type adult T-cell leukemia, who demonstrated a spontaneous decrease in leukemic cell number, apparently coincident with apoptotic cell death. On admission the patient's white blood cell count was 38.9 x 10(9)/l with 77% abnormal lymphocytes. He also had hypoproteinemia (4.3 g/dl) from protein losing enteropathy. After admission the leukemic cell count decreased without chemotherapy, reaching 5.9 x 10(9)/l after 2 months. Studies of peripheral lymphocytes demonstrated appearance of the apoptotic cells and dna ladder formation from the beginning of regression. Same truncated proviral dna was recognized in primary ATL cells through the whole clinical course. The hypoproteinemia improved with intravenous nutrition, followed by increase of the leukemic cells. This case is the first report that demonstrates tumor-cell apoptosis induced clinical regression in adult T-cell leukemia. Further, we speculate that the hypoproteinemia may have been involved in the leukemic cell apoptosis.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
2/14. Lymph loss in the bowel and severe nutritional disturbances in Crohn's disease.A severe nutritional deficiency status is described in a 22-year-old patient with Crohn's disease. The clinical picture on admission was dominated by an episode of gastrointestinal bleeding secondary to clotting disturbances (vitamin k deficiency) and severe cachexia due to a protein energy malnutrition. The mechanisms of severe nutritional disturbances in Crohn's disease are multifactorial. In this patient, lymphatic leakage into the intestinal lumen was a major contributing factor in the pathogenesis of protein-losing enteropathy, fat malabsorption, and lymphocytopenia. The authors were able to demonstrate this intestinal lymph loss by nuclear imaging.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
3/14. Intestinal giardiasis: an unusual cause for hypoproteinemia.Malabsorption is a well-known complication of infection with giardia lamblia. However, selective protein-losing enteropathy is rare. We report a child with anasarca due to hypoalbuminemia as a result of gastrointestinal protein loss. Investigations established giardiasis as the etiology. The child returned to normal health after treatment with metronidazole.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
4/14. Stable reversal of pathologic signs of primitive intestinal lymphangiectasia with a hypolipidic, MCT-enriched diet.We report on a patient with protein-losing enteropathy due to primitive intestinal lymphangiectasia with an early reversal of clinical and biochemical signs and a stable late reversal of pathologic signs after treatment with a hypolipidic diet enriched with medium-chain triacylglycerols.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
5/14. A case of toxic shock-like syndrome presenting with serious hypoproteinaemia because of a protein-losing gastroenteropathy.A 37-year-old man was admitted to our hospital because of toxic shock-like syndrome (TSLS) induced by streptococcus pyogenes. After the pathogenic bacteria had been eradicated, serious diarrhoea appeared and a protein-losing gastroenteropathy developed. An immunohistochemical study of the biopsy specimens of both small and large intestines revealed the infiltration of t-lymphocytes, predominantly CD8 cells, into the lamina propria of affected mucosa, villus atrophy and crypt hyperplasia. Considering these histological findings, some immunological mechanism which lead the activation of cytotoxic t-lymphocytes may play an important role in the pathogenesis of this rare intestinal manifestation of TSLS.- - - - - - - - - - ranking = 5keywords = enteropathy (Clic here for more details about this article) |
6/14. A patient with protein-losing enteropathy associated with systemic lupus erythematosus.A 46-year-old woman previously diagnosed as having systemic lupus erythematosus presented with severe hypoalbuminemia and anasarca. She was demonstrated to have protein-losing enteropathy without any other active symptoms of SLE. Her bowel habit was normal and endoscopic examination revealed non-specific colitis and a small ulcer in the duodenum. serum biochemistry showed an abnormal profile of the serum protein, including severe hyperlipoproteinemia and hyperfibrinogenemia. The process of protein-losing was not selective in terms of the molecular size. All of these symptoms and the abnormalities in laboratory data were improved by corticosteroid therapy.- - - - - - - - - - ranking = 5keywords = enteropathy (Clic here for more details about this article) |
7/14. Congenital myotonic dystrophy with progressive edema and hypoproteinemia.We report a patient with congenital myotonic dystrophy who had progressive edema and hypoproteinemia. An atrioseptal defect and patent ductus arteriosus were noted and were considered to be the cause of the right heart failure and edema. Although urinary protein levels were minimal, infusion of albumin did not improve the hypoproteinemia. Administration of dexamethasone increased the serum protein level, but the edema was not ameliorated. autopsy revealed a slight lymphatic dilation in the small intestine, suggesting protein-losing enteropathy.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
8/14. Jejunal vasculitis with protein-losing enteropathy after bone marrow transplantation.A 37-yr-old white man experienced crampy abdominal pain beginning 21 days after successful bone marrow transplantation for chronic myelogenous leukemia. Generalized edema and hypoproteinemia developed. Symptoms persisted until 61 days post-transplant, when the patient developed an acute abdomen. At laparotomy, an edematous segment of jejunum was resected. Pathological examination showed submucosal vasculitis and necrotizing enteritis. serum protein and albumin levels returned to normal within a few weeks after surgery. vasculitis of the gastrointestinal tract should be considered in the differential diagnosis of protein-losing enteropathy after bone marrow transplantation.- - - - - - - - - - ranking = 5keywords = enteropathy (Clic here for more details about this article) |
9/14. Late presentation of small-bowel injury--hypoproteinaemia, anaemia and obstruction. A report of 2 cases.In contrast with traumatic intestinal perforation, the late sequelae of lesser small-bowel injury are not readily recognised. A protracted course of protein-losing enteropathy as an intermediate result of traumatic segmental small-intestinal ischaemia, and a fibrotic stricture with anaemia, intestinal obstruction and bezoar formation as a late result, are illustrated.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
10/14. Intestinal lymphangiectasia--a case report.Primary intestinal lymphangiectasia is a rare cause of protein-losing enteropathy. We report here our first case, a young girl presenting at the age of ten months at the Department of Paediatrics, singapore General Hospital with generalised oedema and diagnosed to have intestinal lymphangiectasia proven by intestinal biopsy. The literature on some aspects of the subjects is also reviewed.- - - - - - - - - - ranking = 1keywords = enteropathy (Clic here for more details about this article) |
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