1/19. Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy.Muscle infarction is a rare complication in patients with diabetes mellitus, probably because of the rich vascular supply of this tissue. We describe a patient with type 1 diabetes who had infarction of the muscles in her right thigh. We report, for the first time, that the patient, in addition to an advanced microvascular disease in the muscle, had increased plasma total homocysteine levels and increased platelet aggregation. These pathologies might have a synergistic effect on the development of this rare complication and should be treated aggressively to prevent further episodes.- - - - - - - - - - ranking = 1keywords = vascular disease (Clic here for more details about this article) |
2/19. spinal cord infarction during use of zolmitriptan: a case report.A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan. The partial lesion of the cord at T7 predominantly involved the spinothalamic pathways on the left side. Clinical features suggested that the lesion was an ischemic infarct, and this was confirmed by an MRI scan. There were no other known risk factors for vascular disease. There has been mild improvement of her symptoms, but most of the symptoms did not resolve. There are isolated case reports of stroke secondary to the use of triptans, however, this is the first case of spinal cord infarction reported following the use of this group of drugs. The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
3/19. Idiopathic intimal hyperplasia of small arteries and arterioles affecting intestines and myocardium.We report the case of a 52-year-old woman dying from a noninflammatory, occlusive vasculopathy. histology showed marked intimal hyperplasia of small arteries of the intestines and myocardium with subsequent infarction of myocardium, large intestine and gallbladder. A comprehensive work up including laboratory studies, clinical investigations and postmortem failed to assign this condition to any of the known vascular diseases.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
4/19. Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis.We present a woman with scleroderma who developed multiple ischemic digits after chemotherapy for lung cancer. The ischemia started during treatment with carboplatin and gemcitabine and required amputation of the affected digits. A review of the literature shows that thrombotic episodes coinciding with chemotherapy are not uncommon, though venous thrombosis occurs more frequently than arterial. Scleroderma patients are at particular risk for digital infarction because of their underlying vascular disease and associated Raynaud's phenomenon. This case illustrates the risk of severe digital ischemia and digital loss in patients with scleroderma during chemotherapy with carboplatin and gemcitabine.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
5/19. Bilateral optic nerve infarction following acute systemic hypotension and anemia--a case report.Presented here are case reports of two patients who became completely blind in both eyes following acute systemic hypotension - in one following bouts of vomiting and in the other after repeated gastrointestinal bleeding. Both patients had severe degree of anemia. There were no other risk factors for vascular disease such as arteriosclerosis or vasculitis.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
6/19. cocaine-induced renal infarction: report of a case and review of the literature.BACKGROUND: cocaine abuse has been known to have detrimental effects on the cardiovascular system. Its toxicity has been associated with myocardial ischemia, cerebrovascular accidents and mesenteric ischemia. The pathophysiology of cocaine-related renal injury is multifactorial and involves renal hemodynamic changes, alterations in glomerular matrix synthesis, degradation and oxidative stress, and possibly induction of renal atherogenesis. Renal infarction as a result of cocaine exposure, however, is rarely reported in the literature. CASE PRESENTATION: A 48 year-old male presented with a four-day history of severe right flank pain following cocaine use. On presentation, he was tachycardic, febrile and had severe right costovertebral angle tenderness. He had significant proteinuria, leukocytosis and elevated serum creatinine and lactate dehydrogenase. Radiographic imaging studies as well as other screening tests for thromboembolic events, hypercoagulability states, collagen vascular diseases and lipid disorders were suggestive of cocaine-Induced Renal infarction (CIRI) by exclusion. CONCLUSION: In a patient with a history of cocaine abuse presenting with fevers and flank pain suggestive of urinary tract infection or nephrolithiasis, cocaine-induced renal infarction must be considered in the differential diagnosis. In this article, we discuss the prior reported cases of CIRI and thoroughly review the literature available on this disorder. This is important for several reasons. First, it will allow us to discuss and elaborate on the mechanism of renal injury caused by cocaine. In addition, this review will demonstrate the importance of considering the diagnosis of CIRI in a patient with documented cocaine use and an atypical presentation of acute renal injury. Finally, we will emphasize the need for a consensus on optimal treatment of this disease, for which therapy is not yet standardized.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
7/19. Diabetic muscle infarction of the peroneus brevis: a case report.Diabetic muscle infarction of the peroneus brevis is a rare complication of diabetes mellitus. It often presents with an acute leg pain without any obvious signs. Due to poor awareness of this condition, it is often misdiagnosed and results in anxiety of the patient and unnecessary investigations. It is ominous as it usually indicates vascular disease of the end organs. We report a case where the patient presented to several physicians for leg pain without any other clinical signs. The diagnosis was suspected on ultrasound and confirmed with biopsy. The symptoms improved dramatically after excision. Although most literature suggests conservative treatment by non-weight bearing and analgesia, the recovery period can last for more than 6 weeks, with a recurrence rate of 50%. We feel that there is a role for excision biopsy of the lesion for both diagnosis and treatment. In this case, symptoms improved remarkably and the patient was able to ambulate without pain 2 days after the operation without needing any analgesia.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
8/19. Severe vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy.Vascular toxicity following the use of vinblastine, bleomycin, and cisplatin (VBP) combination chemotherapy has been described. This report gives details of 5 patients who suffered acute life-threatening vascular events following such a chemotherapy regimen for germ cell tumors. In 3 of the cases no evidence of tumor was found at autopsy. Both an acute and a long-term vascular toxicity were seen. Large artery vascular disease may result from synergistic toxicity of the drugs comprising the regimen. These cases, with an additional 16 collected from the literature, suggest that major vascular disease is a significant side-effect of the VBP regimen.- - - - - - - - - - ranking = 0.4keywords = vascular disease (Clic here for more details about this article) |
9/19. Retinal embolism following percutaneous femoral cerebral angiography.A 35-year-old female without evidence of atherosclerotic vascular disease underwent percutaneous femoral cerebral angiography. Perifoveal retinal infarction by exogenous arteriolar emboli produced a permanent absolute pericentral scotoma. Strict adherence to meticulous angiographic technique may prevent such an angiographic complication.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
10/19. spinal cord infarction in a patient with sickle cell anemia.The most common serious neurologic complication of sickle cell anemia is occlusive vascular disease with central nervous system infarction. The parenchymal lesions are most often located in the brain, chiefly within major cerebral arterial boundary zones. spinal cord infarction is extremely rare. We report a patient with sickle cell anemia who developed an acute cervical myelopathy. At autopsy, there was a spinal cord infarction with extensive involvement of the rostral cervical segments. Recanalized thrombi were present in the right vertebral artery and smaller subarachnoid arterioles adjacent to the infarcted cord. This is the first report of autopsy-confirmed spinal cord infarction associated with sickle cell anemia.- - - - - - - - - - ranking = 0.2keywords = vascular disease (Clic here for more details about this article) |
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