1/33. An infectious mononucleosis-like syndrome induced by minocycline: a third pattern of adverse drug reaction.A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne. His illness was also characterized by a palpable spleen tip, marked lower extremity and scrotal edema, and generalized lymphadenopathy. The patient had leukocytosis with a large percentage of atypical lymphocytes on peripheral smear and liver dysfunction. Titers for Epstein-Barr virus, hepatitis B, toxoplasmosis; and cytomegalovirus were all negative. Human immunodeficiency virus-1 viral load and antibodies were also negative. Marked improvement was noted after the discontinuation of minocycline and the use of systemic corticosteroids. With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
2/33. Heterophil negative infectious mononucleosis like syndrome due to hepatitis b virus.A case of acute viral hepatitis B with features suggestive of infectious mononucleosis in a 20 year girl is described. A differential diagnosis of heterophil negative infectious mononucleosis like syndrome due to varied aetiology based on serology is emphasised.- - - - - - - - - - ranking = 5keywords = hepatitis (Clic here for more details about this article) |
3/33. Active infective endocarditis due to methicillin-resistant staphylococcus aureus in the acute phase of infectious mononucleosis.A 26-year-old male was treated for acute hepatitis due to Epstein-Barr virus and infectious mononucleosis in our hospital. At 2 weeks after admission, there was relapse with high fever. A blood culture detected methicillin-resistant staphylococcus aureus. A two-dimensional echocardiogram revealed severe aortic regurgitation and vegetation on the left coronary cusp of the aortic valve. The diagnosis was active infective endocarditis due to methicillin-resistant staphylococcus aureus in the acute phase of infectious mononucleosis. Following preoperative administration of vancomycin, the aortic valve was replaced with a Carbomedics prosthetic valve. The aortic valve was bicuspid, and the right cusp and non-coronary cusp were conjoined. As the focus of infection was localized to the left coronary cusp, the infected tissue was fully removed with resection of all the cusps. Although fever persisted long after the operation, the blood culture became negative for methicillin-resistant staphylococcus aureus, and repeated echocardiograms including transesophageal echocardiogram showed no prosthetic valve infection. vancomycin was administered until the c-reactive protein became negative at 45 days after the operation.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
4/33. Renal enlargement associated with infectious mononucleosis.A 5 1/2 year old boy developed severe infectious mononucleosis (I.M.) with fever and hepatitis persisting for eight weeks. The diagnosis of I.M. was confirmed serologically by the development of a heterophile antibody and an ox cell hemolysin. During the acute illness, bilaterally enlarged kidneys were noted by intravenous urography even though the patient had no significant clinical or laboratory evidence of renal disease. Fifteen months following discharge, clinical and laboratory findings were normal and the kidneys had decreased markedly in size.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
5/33. infectious mononucleosis presenting as acute hepatitis, with marked leukocytosis and renal involvement.We report a 45-year-old lady with infectious mononucleosis due to Epstein-Barr virus. The unusual features of this case included a negative heterophil antibody test, marked leukocytosis, renal involvement and jaundice.- - - - - - - - - - ranking = 4keywords = hepatitis (Clic here for more details about this article) |
6/33. Diphenylhydantoin sensitivity. a syndrome resembling infectious mononucleosis with a morbilliform rash and cholestatic hepatitis.A ten-year-old boy presented with an illness resembling infectious mononucleosis associated with an unusual skin rash and marked cholestatic hepatitis. This combination represents a rare reaction to diphenylhydantoin. Few reported cases have been published. The illness commences from three to seven weeks after starting therapy. Although one death has been reported, other cases have shown complete recovery. Early recognition of the combination of symptoms and cessation of drug therapy is essential.- - - - - - - - - - ranking = 5keywords = hepatitis (Clic here for more details about this article) |
7/33. Acute hepatitis in childhood: virological, immunological and clinical aspects.Virological, immunological and clinical findings in 7 previously healthy children, aged 18 months to 11 years, with viral hepatitis are reported. Asymptomatic and fully recovering, although protracted, hepatitis B was diagnosed by chance in a 1 1/2 year-old boy. Anicteric and short-term hepatitis occurred in three children with Epstein-Barr virus infection, concomitantly with typical mononucleosis syndrome. On the contrary, cytomegalovirus (CMV)-associated hepatitis was severe and protracted in two children, and fatal in a 4-year-old girl, whose main autoptic finding was submassive hepatic necrosis. Therefore, our study showed that acute viral hepatitis in non-immunocompromised children is generally self-limited and that CMV hepatitis is more frequent and severe than commonly believed.- - - - - - - - - - ranking = 10keywords = hepatitis (Clic here for more details about this article) |
8/33. infectious mononucleosis hepatitis: a case-report.46-year-old Mexican-born who lived in mexico City was admitted to the hospital for evaluation with a two-week history of fever, jaundice, and malaise. Physical examination he had cardiac murmurs. The liver was palpable 2 cm below the costal margins. Liver-function tests showed hypertransaminasemia. The patient had a high titer of anti-EBV IgM antibodies, but tests for all other antiviral antibodies were negative. The liver biopsy shows EBV latent membrane protein.- - - - - - - - - - ranking = 4keywords = hepatitis (Clic here for more details about this article) |
9/33. 1. Fatal acute hepatitis in infectious mononucleosis in a forensic setting: a case report.Mononucleosis is generally considered a benign, self-limited disease. However, though uncommon, fatal complications are sometimes encountered. Deaths from liver failure, splenic rupture, respiratory obstruction, neurological complications, secondary infections and bleeding complications have been described. In the forensic setting, there are a few reports of sudden and unexplained deaths from splenic rupture and upper airway obstruction. We report here the first case of sudden and unexplained death from acute hepatitis in infectious mononucleosis presenting as a suspicious death.- - - - - - - - - - ranking = 5keywords = hepatitis (Clic here for more details about this article) |
10/33. Mononucleosis and hepatic failure associated with diphenylhydantoin treatment in an infant.Diphenylhydantoin-induced hepatitis and mononucleosis are uncommon in children. The occurrence of these two diseases in the same individual, with progression to hepatic failure is rare and has not been reported in infants. This report represents a 6-month-old male infant who developed an infectious mononucleosis-like syndrome and hepatic failure 16 days after diphenylhydantoin administration. He took this anticonvulsant for controlling seizures after a head injury. fever, skin rash, hepatosplenomegaly, lymphadenopathy, and atypical lymphocytosis led to the initial diagnosis of infectious mononucleosis. However, negative heterophil antibody did not support the diagnosis. jaundice ensued in the following course and became more and more profound. Meanwhile, physical examination showed shrinking in liver size. Negative virology studies, including Epstein-Barr virus, cytomegalovirus, and hepatitis b virus, excluded them as causative agents. The patient lapsed into a stage I hepatic coma, but gradually recovered clinically and biochemically after eight successive exchange transfusions and supportive care. Two liver biopsies were performed 20 and 50 days after the onset of disease, respectively. Remarkable hepatic parenchymal loss, cholestasis, and fatty change were found on histologic examination of the first biopsy specimen, and portal fibrosis was noted on the second.- - - - - - - - - - ranking = 2keywords = hepatitis (Clic here for more details about this article) |
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