1/6. Subsequent successful pregnancy and delivery after intracytoplasmic sperm injection in a patient with XY gonadal dysgenesisms.Report of a rare case of subsequent twin delivery after intracytoplasmic sperm injection (ICSI) into donated oocytes in a 30-year-old woman with a diagnosis of XY dysgenesis, who underwent a gonadectomy at the age of 13 years. Her husband suffers from severe oligo-astheno-terato-spermia.- - - - - - - - - - ranking = 1keywords = gonadal dysgenesis, dysgenesis (Clic here for more details about this article) |
2/6. Successful pregnancy in a patient with a 46,XY karyotype.OBJECTIVE: To report a case of successful pregnancy in a patient with 46,XY karyotype with primary ovarian failure. DESIGN: Case report. SETTING: Fertility research Center, G.G. Hospital, Chennai, Tamil Nadu, india. PATIENT(S): A 27-year-old woman with hypoplastic uterus, normal fallopian tubes on both sides, and gonadal dysgenesis. INTERVENTION(S): Chromosomal analysis, diagnostic laparoscopy, donor oocyte program, gamete intrafallopian transfer, and gonadectomy. MAIN OUTCOME MEASURE(S): Response to hormone replacement therapy and the probability of achieving a pregnancy by a tubal procedure. RESULT(S): Treatment was successful, and the patient delivered a live baby. CONCLUSION(S): A hypoplastic uterus of patients with the 46,XY karyotype can be stimulated by the use of cyclical steroid therapy to accommodate pregnancy and facilitate tubal procedures in patients with normal fallopian tubes.- - - - - - - - - - ranking = 0.2467866944919keywords = gonadal dysgenesis, dysgenesis (Clic here for more details about this article) |
3/6. Successful pregnancy in a pure gonadal dysgenesis with karyotype 46,XY patient (Swyer's syndrome) following oocyte donation and hormonal treatment.A pregnancy obtained in a patient with 46XY gonadal dysgenesis (Swyer's syndrome) after ovum donation and IVF/ET is described. The efficacy of this technique in overcoming particular cases of otherwise irreversible infertility is discussed.- - - - - - - - - - ranking = 1.2339334724595keywords = gonadal dysgenesis, dysgenesis (Clic here for more details about this article) |
4/6. Swyer syndrome with SRY y chromosome and rudimentary internal genitalia demonstrating temporary action of antimullerian hormone in utero: a case report.BACKGROUND: XY gonadal dysgenesis is characterized by streak gonads in phenotypic females without somatic abnormalities. This case demonstrated a hypoplastic uterus, an unlikely finding for the syndrome, suggesting insufficient function of antimullerian hormone prenatally. CASE: A 20-year-old, female virgin was first seen 2 years earlier complaining of primary amenorrhea. She was 168 cm tall, and secondary sexual characteristics, such as breast development and pubic and axillary hair, were absent on physical examination. Chromosome analysis with fluorescence in situ hybridization revealed 46,XY, and a molecular investigation was undertaken to assess the possibility of a mutation in SRY through dna sequencing. SRY mutations were absent. Bilateral laparoscopic removal of dysgenetic gonads was performed at another medical center immediately after genetic confirmation for an increased risk of malignancy. When the patient was seen 1 year later, we performed ultrasonography because of no menstrual outflow. Pelvic ultrasonography revealed a hypoplastic uterus (26 x 12 mm) with a rudimentary cervix. CONCLUSION: Clinical phenotypes of different mutations of the y chromosome, particularly on SRY, may cause Swyer syndrome patients to have a uterus with fertility potential after oocyte donation.- - - - - - - - - - ranking = 0.2467866944919keywords = gonadal dysgenesis, dysgenesis (Clic here for more details about this article) |
5/6. 46,XY gonadal dysgenesis: three case reports demonstrating an evolution in management.Treatment of phenotypic females with XY gonadal dysgenesis is evolving. In the past, these patients have routinely undergone hysterectomy with bilateral gonadectomy. Since the major concern in women with XY gonadal dysgenesis is ovarian malignancy, these patients need not only gonadectomy but frozen section and appropriate surgical staging based on histologic findings. However, even women with stage I dysgerminoma do not require hysterectomy. The state of the art in reproductive endocrinology makes it possible for us not only to offer them the development of secondary sexual characteristics with cyclic replacement therapy, but also the opportunity for childbearing with the use of embryo transfer.- - - - - - - - - - ranking = 1.4807201669514keywords = gonadal dysgenesis, dysgenesis (Clic here for more details about this article) |
6/6. A patient with pure gonadal dysgenesis, gonadal tumour and virilisation.A phenotypic female, karyotype XY presented with virilisation and amenorrhoea. The gonads showed evidence of oestrogen and testosterone production and, in view of the risk of malignancy, a laparotomy was performed. A streak gonad was present on one side with a streak gonad containing discrete tumours on the other. The uterus and fallopian tubes were present. Removal of the gonads and uterus and subsequent oestrogen replacement therapy have produced a satisfactory clinical result.- - - - - - - - - - ranking = 0.98714677796759keywords = gonadal dysgenesis, dysgenesis (Clic here for more details about this article) |