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1/1. Intracranial giant cell arteritis with fatal middle cerebral artery territory infarct.

    A 37 year-old man who developed a fatal middle cerebral territory infarct was found at autopsy, to have widespread granulomatous angiitis involving meningeal and intracranial--extracerebral vessels but not intracerebral vessels or other extra-cranial vessels. The findings are unique and overlap with those of granulomatous angiitis of the nervous system (GANS) and classic giant cell arteritis (GCA). A possible precipitant for this devastating illness was a recent chlamydia infection. The salient clinical and pathologic differences between GANS and GCA of the nervous system are discussed.
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