1/4. Keloidal Kaposi's sarcoma: report of three patients.Kaposi's sarcoma is a unique neoplasm which has emerged as an important element of AIDS in homosexuals but not in others at high risk for AIDS. The biology of this important tumor may be related to cytokines secreted by hiv-infected cells and/or by Kaposi's sarcoma cells themselves. We report 3 patients with multiple keloid-like tumors. These lesions proved to be Kaposi's sarcoma histologically, yet with a unique keloidal component. This variant has not been described previously. It is possible that cytokines that stimulate Kaposi's sarcoma cell growth may also stimulate proliferation of local fibroblasts to produce this variant.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
2/4. thallium-201 uptake in keloid tissue masquerading as a pulmonary neoplasm.Tl-201 imaging is useful in the diagnostic work-up of tumors. However, Tl-201 uptake is not specific for tumor and is also noted in other conditions. A case is described in which Tl-201 was taken up by a keloid.- - - - - - - - - - ranking = 4keywords = neoplasm (Clic here for more details about this article) |
3/4. Keloidal basal cell carcinoma. A new clinicopathological variant of basal cell carcinoma.Basal cell carcinoma is the commonest malignant neoplasm of the skin. Clinical and histopathological variants are well known. We describe two patients with nodular lesions on the face, clinically suggestive of keloids, but with no previous history of injury at that site. Histopathological study, in both cases, demonstrated characteristic basaloid neoplastic aggregations of basal cell carcinoma, intermingled with thick, sclerotic, keloidal collagen bundles in the stroma. This peculiar stroma is responsible for the clinical and histopathological characteristics. We propose the name of keloidal basal cell carcinoma for this striking and distinctive variant of basal cell carcinoma.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
4/4. Solitary fibrous tumor of the skin.Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that most commonly involves the pleura, but is increasingly more often observed in extrapleural locations. A 37-year-old woman presented with an SFT involving the skin and subcutaneous tissue of the scalp. Histologically, SFT is well circumscribed and composed of uniform spindle cells arranged in interlacing fascicles. It exhibits alternating hypercellular and hypocellular areas with abundant thick, often keloid-like, hyalinized collagen. hemangiopericytoma-like areas are frequently prominent. Immunohistochemical markers for smooth muscle, neural, and epithelial differentiation are negative, but generalized positivity for CD-34 is characteristic. Because of the expanding spectrum of anatomic involvement of SFT, it is not surprising that on rare occasions this tumor may involve the skin.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |