1/29. A poroid neoplasia arising close to a seborrheic keratosis and a trichoepithelioma.A 69-year-old woman had a well-defined, slightly raised, brownish, keratotic plaque with an eccentric group of roughly circular, bluish, dome nodules on her right scapular area. Histological study revealed the presence of an eccrine poroma demonstrating features of eccrine poroma, hidroacanthoma simplex, and dermal duct tumor and arising in a lesion of seborrheic keratosis and a trichoepithelioma. In the eccrine poroma region, an area with malignant changes was evident. The findings in this case support the view of eccrine poroma as a spectrum of histological variants and the possibility of malignant transformation from a eccrine poroma towards porocarcinoma. The association with seborrheic keratosis is most probably coincidental, and the trichoepithelioma was probably due to induction of the tumoral stroma on adjacent follicular epithelia.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
2/29. Coexistence of acanthosis nigricans and the sign of Leser-Trelat in a patient with gastric adenocarcinoma: a case report and literature review.The association of acanthosis nigricans (AN) with the sign of Leser-Trelat (LT) and gastric carcinoma is rare. Our patient was a 69-year-old man, who presented with hematemesis; a stage-IV poorly differentiated, diffuse-type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed.- - - - - - - - - - ranking = 11.26250147192keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
3/29. Multiple fibroepithelial basal cell carcinoma of Pinkus associated with seborrheic keratosis in a nevoid distribution.We describe a patient with multiple fibroepithelial basal-cell carcinoma (FEBCC) associated with seborrheic keratosis distributed in a neviform fashion on the left side of the body and clinically resembling skin tags.- - - - - - - - - - ranking = 5keywords = carcinoma (Clic here for more details about this article) |
4/29. The sign of Leser-Trelat in a case of adenocarcinoma of the lung.This is what we believe to be the first report of the sign of Leser-Trelat in association with occult adenocarcinoma of the lung. The sign of Leser-Trelat is proposed as a sign of possible occult malignancy, despite various suggestions to the contrary. Also, it is suggested that a tumor-produced humoral factor (eg, transforming growth factor-alpha [TGF-alpha]) could be responsible for both the acute eruption of the monomorphous seborrheic keratoses and the nearly concomitant development of acanthosis nigricans, which occurred in our case. The possible distinction between a hyperplastic and a neoplastic origin of various types of seborrheic keratosis is discussed in relation to this hypothetical humoral factor. In addition, we suggest a refinement of the definition of the sign of Leser-Trelat and discuss the use of "sign of Leser-Trelat" and "syndrome of Leser-Trelat" in relation to physical findings. All patients with the sign of Leser-Trelat should undergo a thorough evaluation for occult malignancy.- - - - - - - - - - ranking = 10.26250147192keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
5/29. Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma.Although seborrheic keratoses of the vulva are described in textbooks, to our knowledge, inverted follicular keratosis has not been reported. A 27-year-old woman underwent an excisional biopsy for a small lesion of the left labium majus. Squamous cell carcinoma was considered in the clinical differential diagnosis. The initial pathologic diagnosis suggested squamous cell carcinoma in situ, and the consultation diagnosis was superficially invasive squamous cell carcinoma. On pathologic examination, a symmetrical, endophytic, epithelial tumor was observed consisting of a proliferation of basaloid cells with many areas of reactive squamous cells showing numerous squamous eddies, focal reactive nuclear atypia, and occasional mitotic figures. After the pathologic diagnosis of inverted follicular keratosis was made, a history of close perineal shaving and total body tanning was obtained. Because inverted follicular keratosis is postulated to be related to follicular injury, it is likely that the trauma of close shaving is a significant etiologic factor. There is less evidence that ultraviolet ray exposure is of etiologic importance.- - - - - - - - - - ranking = 7keywords = carcinoma (Clic here for more details about this article) |
6/29. The sign of Leser-Trelat: a paraneoplastic cutaneous syndrome that facilitates early diagnosis of occult cancer.The sign of Leser-Trelat has been described as a rare cutaneous marker of internal malignancy. We report a patient presenting with the sign of Leser-Trelat, in whom a limited diagnostic workup for an associated malignancy lead to the early diagnosis of asymptomatic renal cell carcinoma and curative tumor nephrectomy. A review on this and other cutaneous paraneoplastic syndromes is given. Since they may be the only presenting sign of an occult cancer, patients with these syndromes should undergo a diagnostic screening program for malignant disease.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
7/29. Non-ulcerative basal cell carcinoma arising on the genitalia.We report two cases of basal cell carcinoma (BCC) arising on the genitalia. The first case was a 49-year-old male who became aware of a dull erythematous plaque with a keratotic surface on his scrotal skin, and the second case was a 44-year-old female suffering from a keratotic plaque on her right vulvar region. Neither lesion was ulcerative. Both were resected under local anesthesia following a clinical diagnosis of angiokeratoma for the former and seborrheic keratosis or BCC for the latter lesion. Histopathological study revealed that both lesions were BCC. Many questions regarding the pathogenesis of BCC still remain to be clarified. Because most of the reported cases have been ulcerative lesions and the genital region is an uncommon site for BCCs, caution should be taken in cases in whom a clinically non-ulcerative tumor suspected to be angiokeratoma or seborrheic keratosis arises in this region.- - - - - - - - - - ranking = 5keywords = carcinoma (Clic here for more details about this article) |
8/29. Herpesvirus infection of seborrheic keratoses.We present three examples of patients with seborrheic keratoses complicated by necrotizing herpesvirus infection. Two patients had localized cutaneous herpetic infections, and the third patient had a generalized cutaneous herpesvirus infection. Two of the lesions were thought to be squamous cell carcinoma. The third was clinically identified as inflamed seborrheic keratosis. Herpesvirus infection was not clinically suspected in two of the patients. The histologic changes were similar in all cases. Epidermal proliferation was accompanied by hyperkeratosis and pseudo horn cyst formation. Extensive keratinocyte necrosis was present along with balloon degeneration of keratinocytes, herpetic viral inclusions, and multinucleated giant cells. Viral lesions of molluscum contagiosum and human papillomavirus have been observed in benign skin proliferations. Nevertheless, we were unable to find descriptions of herpesvirus involvement in seborrheic keratosis in a medline search. Necrotic seborrheic keratoses should be carefully examined for the possibility of herpesvirus infection, a condition that may be improved by prompt medical intervention as demonstrated in one of our cases.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
9/29. Sign of Leser-Trelat associated with adenocarcinoma of the rectum.The acute onset and/or rapid increase in size and number of multiple seborrheic keratoses associated with internal malignancy is called sign of Leser-Trelat. Although some authors reject its existence, there are more than 80 well-documented case reports in the literature. Here, we report a 75-year-old man who presented with abrupt appearance of multiple seborrheic keratoses without any suspicious symptom of cancer. The screening for malignant neoplasms let us detect a rectal adenocarcinoma that was in a curative stage. This case-report illustrates a true sign of Leser-Trelat, and proves that these patients must be appropriately investigated for underlying malignancy.- - - - - - - - - - ranking = 10.26250147192keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
10/29. The leser-trelat sign in association with carcinoma of the ampulla of vater.A 45-yr-old woman was admitted to our hospital for surgical treatment of obstructive jaundice. She was treated by a standard pancreatoduodenectomy (Whipple procedure). The biopsy of the specimen disclosed an adenocarcinoma of the ampulla of vater. Six months before the appearance of the obstructive jaundice, she noted a sudden onset of many seborrheic keratoses on the upper part of her trunk and upper extremities. This, to our knowledge, is the first case of Leser-Trelat sign associated with adenocarcinoma of the ampulla of vater.- - - - - - - - - - ranking = 8.105000588768keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
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