1/14. Keratotsis punctata of the palmar creases: report of two cases associated with ichthyosis vulgaris.Two patients with keratosis punctata of the palmar creases are described. The association with ichthyosis vulgaris and other disorders of keratinization is discussed. In both cases, histopathology revealed a close relation between the keratotic plug and the sweat glands. The role of genetic factors and manual activity in the pathogenesis is discussed. Treatment with oral etretinate resulted in a good improvement in the first patient, but prolonged low-dose maintenance therapy was required to prevent recurrence.- - - - - - - - - - ranking = 1keywords = sweat gland, sweat, gland (Clic here for more details about this article) |
2/14. Proliferative actinic keratosis: three representative cases.OBJECTIVE: This article describes a new subtype of actinic keratosis that exhibits proliferative characteristics both histologically and clinically. We describe three representative cases occuring in the presence of infiltrative squamous cell carcinoma (SCC) and/or basal cell carcinoma (BCC). methods: Histories of each lesion in the three cases discussed were obtained. The lesions were removed by Mohs micrographic surgery. Permanent sections, stained with hematoxylin and eosin, were examined and studied under light microscopy. RESULTS: All three lesions had failed conventional treatment with liquid nitrogen and/or 5-fluorouracil (5-FU). Histologic examination of the lesions revealed sheets of dysplastic cells growing along the basal layer of the epidermis and migrating down hair follicles and sweat ducts. An associated infiltrative SCC and/or BCC was found in each case. CONCLUSIONS: Proliferative actinic keratosis is resistant to standard therapies because of deep migration of abnormal cells along hair follicles and sweat ducts. It has a strong propensity to develop infiltrative SCC and may occur concomitantly with BCC.- - - - - - - - - - ranking = 0.36556911248742keywords = sweat (Clic here for more details about this article) |
3/14. Host-vs.-altered-host eruptions in patients on liposomal doxorubicin.BACKGROUND: Anthracycline antitumor antibiotics are the most commonly used chemotherapeutic agents. One of these is doxorubicin. Liposomal doxorubicin was developed as a drug delivery system in order to deliver the active drug intracellularly while decreasing the systemic toxicity, particularly hematological and cardiac toxicity. methods: The clinical and histologic findings of the cutaneous eruptions of associated with liposomal doxorubicin are reviewed. RESULTS: The eruptions occurred in three women with metastatic ovarian carcinoma who were treated with liposomal doxorubicin. These three patients developed erythematous macular/papular to plaque cutaneous lesions, and in one patient a vesicular component. The eruptions involved the trunk and extremities approximately 3-4 weeks after completions of therapy. None of the patients had any documented infections, and none of the patients had symptoms other than pruritus. The eruptions cleared over a period of weeks to months. Histologic features included an interface dermatitis with numerous apoptotic/dyskeratotic cells within the epidermis, with involvement the intra-epidermal sweat ducts and the infundibulum of hair follicles. CONCLUSION: We believe that these eruptions represented a chemotherapy induced host-vs.-altered host reaction.- - - - - - - - - - ranking = 0.18278455624371keywords = sweat (Clic here for more details about this article) |
4/14. Morphological and biochemical studies of human beta-mannosidosis: identification of a novel beta-mannosidase gene mutation.BACKGROUND: There are seven well-known lysosomal storage diseases that produce angiokeratoma corporis diffusum clinically. beta-mannosidosis (MANB1; OMIM248510), first reported in humans in 1986, is a rare hereditary lysosomal storage disease caused by a deficiency of the enzyme beta-mannosidase. Since then, 13 cases of beta-mannosidase deficiency in ten families have been described. A human beta-mannosidase mutation has been reported only by Alkhayat et al. in 1998. OBJECTIVES: To clarify its pathogenesis we did electron microscopic, biochemical and molecular biological investigations of a Japanese patient with beta-mannosidosis. methods: Ultrastructural analyses, enzyme assays, cell culture and mRNA and genomic dna were sequenced to find mutations in the beta-mannosidase gene. RESULTS: Electron microscopy of skin biopsy specimens from the patient showed cytoplasmic vacuolation of lysosomes in blood and lymph vessels, endothelial cells, fibroblasts, secretory portions of eccrine sweat glands, neural cells and basal keratinocytes in the epidermis. This vacuolation was also observed in cultured keratinocytes and fibroblasts. Assays of seven enzyme activities in plasma and cultured skin fibroblasts showed a marked decrease of beta-mannosidase activity. Sequencing the beta-mannosidase cDNA revealed a four-base (ATAA) insertion between exons 7 and 8, resulting in a frameshift at codon 321 and termination at codon 325. Analysis of the patient's genomic dna revealed a novel homozygous A( 1)-->G splice site mutation in intron 7. CONCLUSIONS: To our knowledge, this is the first case of beta-mannosidosis reported in japan and the second report in which a gene mutation is identified. The biological importance of beta-mannose moieties in glycoproteins in basal keratinocytes is suggested.- - - - - - - - - - ranking = 1keywords = sweat gland, sweat, gland (Clic here for more details about this article) |
5/14. Porokeratotic eccrine ostial and dermal duct nevus. Report of a case of adult onset.We describe the case of a 38-year-old woman with adult-onset porokeratotic eccrine ostial and dermal duct nevus. The patient had a 9-year history of multiple keratotic papules and comedo-like pits on the medial border of the left foot. light- and electron microscopic studies showed multiple cornoid lamella-like parakeratotic columns, which invariably were associated with hyperplastic eccrine ostia and distal sweat ducts. It is concluded that this entity, the first reported case of adult-onset porokeratotic eccrine ostial and dermal duct nevus, is a variant of the congenital form described previously by Abell and Read and by Aloi and Pippione.- - - - - - - - - - ranking = 0.18278455624371keywords = sweat (Clic here for more details about this article) |
6/14. Hidrotic ectodermal dysplasia: a clinical and ultrastructural observation.Hidrotic ectodermal dysplasia (HED) was observed in a 49-year-old Japanese man. His clinical signs included alopecia, dystrophic nails and palmoplantar keratoderma, but his teeth, facial appearance and sweating were normal. In his family, 9 members in 5 generations were affected, suggesting that the disorder has an autosomal dominant mode of inheritance. biopsy specimens of the hyperkeratotic lesions of the palm and sole were studied with an electron microscope. The most prominent feature was the increase of the number of desmosomal discs in the thickened stratum corneum, suggesting that hyperkeratosis observed in HED is due to the delayed desquamation of the stratum corneum.- - - - - - - - - - ranking = 0.18278455624371keywords = sweat (Clic here for more details about this article) |
7/14. Unusual acquired hyperkeratosis: a case report.The authors describe an acquired hyperkeratosis occurring in a 74-year-old male. To the authors' knowledge this disease shows a pathological picture never before described in the literature, consisting of the presence of a large number of acrosyringum-like structures not connected with the dermal sweat ducts in hyperkeratotic skin.- - - - - - - - - - ranking = 0.18278455624371keywords = sweat (Clic here for more details about this article) |
8/14. cheilitis glandularis: a re-evaluation.cheilitis glandularis (CG) has been attributed to hyperplasia of labial salivary glands. We studied labial biopsy specimens of five patients with clinical CG and compared their salivary tissue with that seen in patients without CG. The labial glands from patients with CG did not differ in size, depth, or histologic appearance from those seen in the controls. They showed little or no inflammation and no hyperplasia. We also reviewed forty-eight cases of CG described in the literature. The accompanying photomicrographs nearly always depicted normal-appearing labial salivary glands. The case histories and clinical descriptions suggested that many examples of CG were manifestations of actinic cheilitis, whereas others may have been unusual presentations of atopic or factitious cheilitis. We believe CG represents an unusual reaction pattern in response to chronic irritation of the lips and is unrelated to labial salivary gland hyperplasia.- - - - - - - - - - ranking = 0.014679286492261keywords = gland (Clic here for more details about this article) |
9/14. Porokeratotic eccrine ostial and dermal duct naevus.With rare exceptions, the presence of cornoid lamellae in skin biopsy specimens is considered diagnostic of porokeratosis. Since the initial descriptions of this condition by Mibelli (1893) and Respighi (1893), there has been debate concerning its relationship to the eccrine sweat duct. This paper describes an epidermal naevus, which pathologically demonstrated gross examples of cornoid lamellae associated exclusively with the eccrine duct and ostia, and which appears to represent a naevus or benign hamartoma of these structures. This entity needs to be clearly differentiated from porokeratosis of Mibelli.- - - - - - - - - - ranking = 0.18278455624371keywords = sweat (Clic here for more details about this article) |
10/14. Coexistence of subepidermal calcified nodule and keratosis punctata in a patient with hyperhidrosis.A 47-year-old female with hyperhidrosis developed multiple subepidermal calcified nodules and keratosis punctata on her palms. Although calcification was not detected on eccrine sweat glands around the calcified mass by histologic examination, it was supposed that the eccrine sweat glands may have played a role in inducing these two lesions in our case.- - - - - - - - - - ranking = 2keywords = sweat gland, sweat, gland (Clic here for more details about this article) |
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