1/30. Neuroendocrine lung tumors and disorders of the neuromuscular junction.We report four cases of lambert-eaton myasthenic syndrome (LEMS) or myasthenia gravis (MG) associated with pulmonary neuroendocrine carcinoma having prolonged survival. The tumors were atypical carcinoid or large cell neuroendocrine carcinoma. LEMS is associated with several neuroendocrine carcinomas. Because some neuroendocrine carcinomas have a better prognosis, aggressive tissue diagnosis of lung cancer in LEMS is warranted. Whether the association between MG and atypical carcinoid is a significant co-occurrence is uncertain.- - - - - - - - - - ranking = 1keywords = carcinoma, lung (Clic here for more details about this article) |
2/30. Poorly differentiated carcinoma of the lung presenting with Lambert--Eaton myasthenic syndrome.lambert-eaton myasthenic syndrome commonly seen in small-cell lung cancer represents an autoimmune reaction against antigens coexpressed by tumor and neurons. It is rarely seen with other histologic subtypes. Symptoms antedate the appearance of the neoplasm by weeks to years. Therapeutic options range from immunosuppression, plasmapheresis, pharmacologic facilitation of neuromuscular transmission, and definitive therapy of the primary tumor. This case report describes the rare association of lambert-eaton myasthenic syndrome with non-small-cell lung cancer.- - - - - - - - - - ranking = 7.1224166354975keywords = cell lung, carcinoma, lung (Clic here for more details about this article) |
3/30. lambert-eaton myasthenic syndrome in association with transitional cell carcinoma: a previously unrecognized association.The lambert-eaton myasthenic syndrome is known to occur with, or precede, a variety of malignancies, most commonly oat cell carcinoma of the lung. We report the first case of this syndrome associated with transitional cell carcinoma of the bladder and ureter. A brief review of published reports on the presentation, diagnosis, and treatment is included.- - - - - - - - - - ranking = 1.3898940515706keywords = carcinoma, lung, cell carcinoma (Clic here for more details about this article) |
4/30. myasthenia gravis with a paraneoplastic marker.Ocular manifestations of myasthenia gravis are very common. myasthenia gravis may be associated with lung carcinoma. Lambert-Eaton syndrome is also commonly associated with lung carcinoma and can have ocular manifestations. Overlap of these two entities has been described. The case of a patient with fatigable diplopia and ptosis 3 years after removal of a large-cell lung carcinoma is presented. Tests results for acetylcholine receptor binding and modulating antibodies were positive for myasthenia gravis. Test results for presynaptic voltage-gated calcium channel antibodies of the N-type were also positive. However, test results for the P/Q-type voltage-gated calcium channel antibodies, which are consistent with Lambert-Eaton syndrome, were negative. autoantibodies can be used to serologically distinguish paraneoplastic myasthenia gravis from Lambert-Eaton syndrome.- - - - - - - - - - ranking = 9.7697360068457keywords = cell lung, lung carcinoma, carcinoma, lung (Clic here for more details about this article) |
5/30. Chronic multiple paraneoplastic syndromes.A patient presented with symptoms of limbic and brainstem encephalitis, motor and sensory neuronopathy, cerebellar dysfunction, and highly positive anti-Hu antibodies. He also harbored P/Q-type calcium channel antibodies and manifested the lambert-eaton myasthenic syndrome (LEMS). Small-cell lung cancer was found, and he received both antineoplastic therapy and intravenous immunoglobulin (IVIg). Remission of the malignancy was achieved. Although the anti-Hu-related manifestations improved after therapy, LEMS has persisted, leading to IVIg dependency.- - - - - - - - - - ranking = 3.1015142919194keywords = cell lung, lung (Clic here for more details about this article) |
6/30. Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma.Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with lambert-eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.- - - - - - - - - - ranking = 1.676730851674keywords = carcinoma, cell carcinoma (Clic here for more details about this article) |
7/30. Lambert-Eaton myaesthenic syndrome: a possible association with Hodgkin's lymphoma.lambert-eaton myasthenic syndrome is a presynaptic neuromuscular junction disorder typically associated with small cell lung carcinoma. The characterstic electrophysiological abnormality is a low amplitude compound muscle action potential that shows a marked increment after maximal voluntary contraction or brief tetanic nerve stimulation. We describe a patient who had LEMS in association with Hodgkin's disease. A 61 year old woman presented with proximal muscle weakness 6 years following successful treatment of Hodgkin's disease. Her symptoms responded well to treatment with diaminopyridine. 9 additional patients have been described with LEMS in association with lymphoproliferative diseases. A systemic malignancy is usually found within 2 years of LEMS diagnosis but may present later. LEMS should be considered in patients with Hodgkin's disease presenting with muscle weakness.- - - - - - - - - - ranking = 37.451526954564keywords = small cell lung, cell lung, lung carcinoma, small cell, carcinoma, lung (Clic here for more details about this article) |
8/30. paraneoplastic syndromes associated with lung cancer: a unique case of concomitant subacute cerebellar degeneration and lambert-eaton myasthenic syndrome.IMPLICATIONS: We report an unusual case in which a patient with paraneoplastic subacute cerebellar degeneration (a brain disorder resulting from antibody production by a tumor located outside the skull) developed lambert-eaton myasthenic syndrome (antibody-mediated skeletal muscle weakness) that was not apparent until she underwent surgery. Failure to recognize this disease process can cause life-threatening respiratory distress.- - - - - - - - - - ranking = 0.32244779336557keywords = lung (Clic here for more details about this article) |
9/30. lambert-eaton myasthenic syndrome in children.lambert-eaton myasthenic syndrome is a presynaptic disorder of neuromuscular transmission. It is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction. It is most often associated with small cell carcinomas of the lung. Rare cases have been reported in children. We recently encountered two children with lambert-eaton myasthenic syndrome associated with antibodies to P/Q-type calcium channel but without evidence of neoplasms. Both patients showed prolonged and significant improvement following cyclosporin treatment. The diagnosis of lambert-eaton myasthenic syndrome should be considered in children with progressive weakness and a negative work-up for the usual causes. High-frequency repetitive nerve stimulation and P/Q-type calcium-channel antibodies may confirm the diagnosis.- - - - - - - - - - ranking = 1.6997630009038keywords = small cell, carcinoma, lung, cell carcinoma (Clic here for more details about this article) |
10/30. Use of intravenous immunoglobulin in lambert-eaton myasthenic syndrome.The authors report a case of a 65-year-old woman with small cell lung cancer who had profound, progressive lower extremity weakness, intermittent blurred vision, a dry mouth, and orthostatic hypotension. Results of laboratory and electrodiagnostic studies were consistent with the diagnosis of lambert-eaton myasthenic syndrome. The patient was treated with one course of intravenous immunoglobulin and had significant improvement.- - - - - - - - - - ranking = 35.282527681816keywords = small cell lung, cell lung, small cell, lung (Clic here for more details about this article) |
| | Next -> |