1/24. The hyperkeratotic variant of disseminated superficial actinic porokeratosis (DSAP).A 78-year-old South Korean man was referred to us from the Medical intensive care Unit (MICU) for an opinion. He was comatose and was on ventilatory care due to aspiration pneumonia. Multiple tiny papules had developed 10 years previously and since then the number and size had been increasing gradually. He had been diabetic for the past 4 years, and had Parkinson's disease diagnosed 1 year previously. Laboratory examinations revealed an elevated level of white blood cells (WBCs) (25,000/microL) and decreased hemoglobin (8.8 g/dL). Other laboratory results were negative or within normal limits. skin examination showed multiple, discrete, crust-like, brownish papules over the erythematous base on the face, upper extremities, and lower extremities. With the clinical impressions of irritated verruca vulgaris, seborrheic keratosis, or cutaneous fungal infection, a skin biopsy was taken from a papule on the left shin, and histopathologic examination revealed several pronounced hyperkeratotic and parakeratotic columns, and characteristic cornoid lamellae in the stratum corneum. Beneath the cornoid lamellae, the granular layer was decreased. A number of round or oval, dyskeratotic, homogenized eosinophilic cells with pyknotic nuclei were scattered in the prickle cell layer below the cornoid lamellae. A mild lymphohistiocytic infiltrate was observed in the papillary dermis and around the blood vessels in the upper dermis. Also, actinic degeneration was present in the upper dermis.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
2/24. Superficial spreading (and disappearing) seborrheic keratosis.A rapidly spreading plaque of seborrheic keratosis developed following liquid nitrogen treatment and involuted quietly after a dermatitis developed; polymerase chain reaction of the tissue did not demonstrate papillomavirus dna. Seborrheic keratoses can both develop and involute from more than one cause.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
3/24. Disseminated superficial actinic porokeratosis associated with topical PUVA.Disseminated superficial actinic porokeratosis (DSAP) is associated with sun exposure and tanning bed usage and has been rarely reported in association with systemic PUVA. We report the first case of DSAP occurring after topical foot PUVA.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
4/24. Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol.Hyperkeratosis lenticularis perstans (HLP) or Flegel's disease is a rare dermatosis characterized by asymptomatic hyperkeratotic papules predominantly located on the lower extremities. Lesional and non-lesional epidermis samples were studied by light- and electron-microscopic examination. The main ultrastructural finding was the presence of structurally altered Odland bodies/membrane-coating granules. Different therapeutic options for HLP have been reported, but none of the treatments was shown to be consistently effective. Here, we report on a patient with Flegel's disease who did respond to topical 5-fluorouracil, whereas topical vitamin d(3) synthetics were ineffective.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
5/24. Acquired crateriform hyperkeratotic papules of the lower limbs: an unusual variant of acrokeratoelastoidosis of Costa.We report a man with a 3-year-history of a striking eruption of small, 2-3 mm diameter keratotic, crateriform papules distributed symmetrically over the lower limbs. Morphologically the individual papules closely resembled those described in acrokeratoelastoidosis (AK) of Costa and in focal acral hyperkeratosis of Dowd (FAH). The case is unusual, however, in that there was dramatic involvement of the legs but the hands and feet were largely spared. Current terms used for these entities are unsatisfactory.- - - - - - - - - - ranking = 0.2keywords = keratosis (Clic here for more details about this article) |
6/24. Bowen disease associated with porokeratosis of Mibelli.A 73-year-old woman developed Bowen precancerous dermatosis in an area of porokeratosis of Mibelli on her leg. This is the fourth reported case of Bowen disease arising from porokeratosis of Mibelli. The recent literature indicates that porokeratosis of Mibelli may be due to an abnormal clone of cells, predisposing affected individuals to development of malignant neoplasms over the involved areas.- - - - - - - - - - ranking = 1.4keywords = keratosis (Clic here for more details about this article) |
7/24. Co-existence of variants of porokeratosis: a case report and a review of the literature.Rarely, different variants of porokeratosis may coexist in an individual patient or their family members. A patient with the linear form of porokeratosis present since birth subsequently developed the disseminated superficial actinic form at a later age. A review of the literature pertaining to the coexistence of variants of porokeratosis suggests a significant association between the linear and disseminated superficial actinic forms. genetic linkage between different variants and the basis for their association is discussed.- - - - - - - - - - ranking = 1.4keywords = keratosis (Clic here for more details about this article) |
8/24. Hyperkeratosis lenticularis perstans (Flegel's disease). Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil.Lesional and perilesional skin samples from a 57-year-old man who had hyperkeratosis lenticularis perstans (HLP) (Flegel's disease) were studied by light and electron microscopic examination. Keratohyalin granules were diminished at the center of a fully-developed lesion. In contrast, keratohyalin appeared normal and membrane-coating granules were found in reduced numbers at the edges of the HLP lesion and were easily detected in normal numbers in clinically normal, perilesional skin. The inflammatory infiltrate in the HLP lesion was composed of small lymphocytes, which often displayed nuclei with deep infoldings resembling Sezary cells, and larger histiocytic cells, many of which were in close contact with the lymphocytes. Peripheral blood mononuclear cells did not show an abnormal ultrastructural appearance. Treatment with topical 5-fluorouracil cream led to the disappearance of the HLP lesions, whereas topical tretinoin was ineffective.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
9/24. porokeratosis in association with lymphoedema.We describe four patients in whom porokeratosis coexisted with lympoedema of the legs. A possible pathogenetic link between the two disorders is discussed, as well as the therapeutic implications and the novel physical sign of lymphoedema bulging through the porokeratotic lesions.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
10/24. Linear porokeratosis.A 66-year-old man presented with linear lesions of 5-years duration on his right lower extremity along Blaschko's lines. physical examination showed hyperpigmented and violaceous papules with hypopigmented centers that were surrounded by fine, raised hyperkeratototic rims. The lesions were characteristic of porokeratosis, and the diagnosis was confirmed by histopathological examination. Associated medical conditions and treatment modalities are reviewed.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
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