1/5. Documented evolution of a solar lentigo into a solitary lichen planus-like keratosis.The purpose of this communication is to report the evolution of a solar (senile) lentigo into a solitary lichen planus-like keratosis (SLPLK). This case is unique because this evolution was documented by biopsies taken from the same lesion nearly 5 years apart. The pathogenesis of SLPLK is discussed.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
2/5. Multiple benign lichenoid keratoses simulating photodermatoses: evolution from senile lentigines and their spontaneous regression.Evidence from several studies has established that a solitary benign lichenoid keratosis evolves from a senile lentigo. This lesion tends to resolve spontaneously with partial or complete regression of the original senile lentigo. In a 2-year period we studied fourteen patients with multiple benign lichenoid keratoses simulating photodermatoses. The original two patients were thought initially to have either cutaneous lupus erythematosus or a drug-induced photodermatitis. All fourteen patients were found to have multiple benign lichenoid keratoses distributed primarily in sun-exposed skin and arising from preexisting senile lentigines. The lichenoid lesions disappear either with topical corticosteroid treatment or spontaneously and are followed by partial or complete regression of the original senile lentigines. This disease entity seems to be fairly common and may be easily confused with photodermatoses.- - - - - - - - - - ranking = 0.2keywords = keratosis (Clic here for more details about this article) |
3/5. Vesiculation of focal acantholytic dyskeratosis in acral lentiginous malignant melanoma.A case of acral lentiginous malignant melanoma is presented in detailed clinical and histologic features because it showed an unusually large vesicle in which there were findings consistent with an exaggerated focal acantholytic dyskeratosis.- - - - - - - - - - ranking = 1keywords = keratosis (Clic here for more details about this article) |
4/5. Spreading pigmented actinic keratosis.We present four cases of spreading pigmented actinic keratoses, an only recently described pigmented lesion of sun-exposed areas, in which the histologic appearance is that of actinic keratosis with the additional feature of excessive melanin deposition in the lower epidermis and in the upper dermis. Clinically, it is a brown patch or plaque with a smooth surface, usually larger than 1 cm, that tends to spread centrifugally. Clinical differential diagnoses include seborrheic keratosis, melanocytic nevus, senile lentigo, lentigo maligna, and lentigo maligna melanoma. This pigmented lesion is probably much more common than the existing literature would indicate.- - - - - - - - - - ranking = 1.2keywords = keratosis (Clic here for more details about this article) |
5/5. radiation lentigo. A distinct cutaneous lesion after accidental radiation exposure.BACKGROUND: Accidental exposure of skin to ionizing radiation leads to long-term alterations such as fibrosis, keratosis, and teleangiectasias. Also, noncharacteristic hyperpigmentation and hypopigmentation may be noted. OBSERVATIONS: A distinct lesion is described on the calves of a white male survivor of the 1986 nuclear accident at Chernobyl, ukraine. Several years after the accident at Chernobyl, characteristic pigmented macules developed in the areas of skin that had previously been exposed to ionizing radiation: there was a marked, sharply demarcated lentiginous hyperpigmentation of epidermal and basal keratinocytes and melanocytes, as well as an increase in the number of melanocytes. No cellular atypia was noted. CONCLUSIONS: This case demonstrates the potential of high single doses of ionizing radiation to induce pigmented lesions with similar clinical and histological features as they have been described after exposure to natural UV radiation or radiation from a tanning bed or sunlamp or after therapy with oral psoralen with long-wave UV-A radiation (PUVA), described as solar, tanning bed, and PUVA lentigines. The absence of cellular atypia may account for a favorable prognosis and enables clear distinction from more serious diagnoses such as lentigo maligna melanoma.- - - - - - - - - - ranking = 0.2keywords = keratosis (Clic here for more details about this article) |