1/7. Lentiginosis profusa. III: Aesthetic and sanguineous aspects.Lentiginosis profusa syndrome and progressive cardiomyopathic lentiginosis are preferable terms to "leopard syndrome". Considerable cosmetic improvement followed facial dermabrasion and light electrodesiccation of lentigines on the exposed surfaces. Hematologic evaluation did not reveal hematopoietic defect in the patient studied.- - - - - - - - - - ranking = 1keywords = leopard syndrome, leopard (Clic here for more details about this article) |
2/7. Gerstmann tetrad in leopard syndrome.We report a 12-year-old boy with multiple lentigines (Leopard) syndrome who was evaluated for learning difficulties and Gerstmann tetrad syndrome (i.e., dyscalculia, left-right disorientation, finger agnosia, and dysgraphia). Cranial computed tomography revealed left ventriculomegaly, more pronounced in the occipital horn suggesting mild atrophy of the left parietal lobe. This is the first report of an association between the Leopard and Gerstmann syndromes and one of the few to demonstrate a computed tomographic abnormality in the latter.- - - - - - - - - - ranking = 4keywords = leopard syndrome, leopard (Clic here for more details about this article) |
3/7. The occurrence of supernumerary teeth with isolated, nonfamilial leopard (multiple lentigines) syndrome: report of case.A case of leopard syndrome with abnormal dental findings of supernumerary teeth is described. The risks involved with providing dental care to patients with this syndrome is also discussed.- - - - - - - - - - ranking = 1.6021569865755keywords = leopard syndrome, leopard (Clic here for more details about this article) |
4/7. Premature cataracts associated with generalized lentigo.Generalized lentigo (leopard syndrome) is an autosomal dominant trait characterized by lentigo, sensorineural deafness, retarded growth (below 25%), ocular hypertelorism, mandibular prognathism, pectus carinatum or excavatum, dorsal kyphosis, winging of the scapulae, valvular pulmonary artery stenosis, electrocardiographic conduction defects, and genitourinary defects. Ocular evaluations of patients with generalized lentigo have revealed the appearance of multiple small white punctate and comma-shaped opacities in the cortex and nuclci of the lenses of affected patients. On the basis of age of the patients examined, it would seem that the corneal opacities first appear in the third decade. Although the opacities may be extensive, the lens opacities do not appear to impair visual function until approximately twenty years after they first appear.- - - - - - - - - - ranking = 1keywords = leopard syndrome, leopard (Clic here for more details about this article) |
5/7. A study of a family with leopard syndrome.We report a family with multiple lentigines syndrome and a manic-like psychosis. The psychosis and multiple lentigines syndrome are genetically unrelated, since the psychosis occurred in a maternal half-sibling of the propositus, while multiple lentigines syndrome occurred in the father of the propositus. The propositus also had Gilbert's syndrome and mitral valve prolapse. No other family members personally examined had either of these last two disorders.- - - - - - - - - - ranking = 4keywords = leopard syndrome, leopard (Clic here for more details about this article) |
6/7. Factitial dermatitis as the presenting sign of multiple lentigines syndrome. Therapeutic effect of autodermabrasion.Factitial dermatitis was the presenting sign of the multiple lentigines syndrome (leopard syndrome) in a young woman. Six years of an unremitting succession of erosive lesions was medically interpreted as a continuous, nonverbal appeal for help in avoiding an undesirable job. Manifestations of her multiple lentigines syndrome included generalized lentigines, mild mental retardation, diabetes mellitus, transitory ECG abnormalities, a cardiac murmur, ocular hypertension, eye muscle paresis, webbed toes, and skeletal deformities of the hands and chest. Through the years, the repetitive sequence of factitial, erosive, nonscarring lesions eradicated her lentigines, leaving the relatively inaccessible back as the only site of residual multiple lentigines.- - - - - - - - - - ranking = 1keywords = leopard syndrome, leopard (Clic here for more details about this article) |
7/7. Diffuse lentiginosis in a patient with Werner's syndrome--a possible association with incomplete leopard syndrome.A classical case of Werner's syndrome is described. In addition to the numerous skin changes that are typically associated with Werner's syndrome, our patients also displayed diffuse lentiginosis, and several of the clinical features of leopard syndrome. Histopathological and ultrastructural findings from a hyperpigmented macule displayed the typical features of a simple lentigo. A striking feature was the presence of melanosomes in langerhans cells as has been reported in the leopard syndrome. A possible generalized mesodermal defect has been suggested in Werner's syndrome, while the basic defect in the leopard syndrome is thought to be of neuroectodermal origin with pleiotropic changes in the organs derived from the mesoderm. Our patient, with incomplete leopard syndrome and typical Werner's syndrome, may be an example of an association of genetic defects affecting both tissues of neuroectodermal and mesodermal origin.- - - - - - - - - - ranking = 8keywords = leopard syndrome, leopard (Clic here for more details about this article) |