1/10. Acute febrile neutrophilic dermatosis (sweet syndrome).We describe the third reported case of acute febrile neutrophilic dermatosis (sweet syndrome) in the united states. In the majority of reported cases, the patients were female. However, in our case and in the two cases reported previously in the united states, the patients were male. In two of these three male patients, a malignant neoplasm has been found, possibly as a coincidence.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
2/10. Chronic lymphocytic leukemia presenting with extreme hyperleukocytosis and thrombosis of the common femoral vein.Very few case reports dealing with chronic lymphocytic leukemia (CLL) and hyperleukocytosis have been reported in the medical literature and none with venous thrombosis as a complication. Here, we describe a 73-year-old woman who presented with newly diagnosed CLL, leukostasis, and hyperleukocytosis (2000 x 10(9)/l), affecting the respiratory and nervous system. In addition, she also had deep vein thrombosis (DVT). Although hypercoagulability and thrombosis are well-described phenomena in solid tumors and in myeloproliferative neoplasms, CLL is generally not associated with an acquired coagulopathy. We hypothesize that in our patient the extreme number of circulating lymphocytes resulted in an abnormal accumulation of lymphocytes possibly causing stasis and occlusion of a larger vessel, which resolved after leukopheresis. The patient has since been successfully maintained with chemotherapy. We conclude that leukopheresis should be considered as the therapy of choice in CLL patients presenting with major complications of leukostasis.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
3/10. Inflammatory pseudotumor of pelvic lymph nodes.BACKGROUND: Inflammatory pseudotumor is a rare benign cause of lymphadenopathy previously reported in several anatomic locations that can simulate malignant neoplasm. CASE: A postmenopausal woman presented with abdominal pain, generalized malaise, leukocytosis, and intermittent fevers up to 102 degrees F. A 5-day course of antibiotics was given with persistence of symptoms. Computed tomography of the abdomen and pelvis demonstrated an ill-defined, retroperitoneal soft-tissue density, and lymphadenopathy. She underwent an exploratory laparotomy, total abdominal hysterectomy, bilateral salpingo-oophorectomy, and unilateral pelvic and paraaortic lymphadenotomy. Histologic examination revealed inflammatory pseudotumor of the lymph nodes, with immunohistochemical studies demonstrating actin-positive myofibroblastic cells. Four months after surgery, the patient remains asymptomatic without evidence of disease. CONCLUSION: Inflammatory pseudotumor of the pelvic lymph nodes is a rare entity and should be included in the differential diagnosis of patients with persistent fever and lymphadenopathy.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
4/10. Hepatocellular carcinoma presenting with pyrexia and leukocytosis: report of five cases.In the past 26 years we have encountered five patients with primary liver malignancy clinically characterized by high remittent fever and leukocytosis mimicking liver abscess. Two patients underwent exploratory laparotomy, and drainage was carried out in another. The clinical courses went rapidly downhill. The liver was cirrhotic in two patients. The interior of the main mass was almost totally necrotic in four cases. Histologically, the malignant cells in the main portion resembled sarcoma, but in some areas cells appeared epithelial with eosinophilic cytoplasm and were in a trabecular arrangement, except for one case not subjected to autopsy in which histological study was inadequate because of extensive necrosis. It seems that these neoplasms were very poorly differentiated hepatocellular carcinomas rather than combinations of sarcoma and hepatocellular carcinoma. These patients, therefore, may represent a distinct clinicopathological type of hepatocellular carcinoma that is very rare in japan but perhaps more common in south africa, where similar cases have been clinically described in larger numbers.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
5/10. Sweet's syndrome and malignancy: a case associated with multiple myeloma and review of the literature.A case of Sweet's syndrome developed as a presenting feature of multiple myeloma. This is the third such case reported, suggesting that myeloma is among the increasing group of neoplasms in which Sweet's syndrome may occur as a paraneoplastic phenomenon.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
6/10. Three cases of oral squamous cancer associated with leukocytosis, hypercalcemia, or both.Three examples of malignant neoplasms primary to the oral cavity and associated with paraneoplastic syndromes are presented. The first case is a squamous cell carcinoma of the maxilla associated with leukocytosis. The second case is a mandibular squamous cell carcinoma associated with hypercalcemia in the absence of bony metastases. The third case is a squamous cancer of the tongue that metastasized to the lumbar vertebrae and right second rib and was associated with both hypercalcemia and leukocytosis. There was no evidence of acute infection or leukemia that could be expected to account for leukocytosis. hypercalcemia in the second case was defined as humoral hypercalcemia of malignancy by biochemical and clinical evaluations. To our knowledge, this is the first definitive report of a carcinoma primary to the oral cavity associated with humoral hypercalcemia of malignancy. In each case, the severity of hypercalcemia, leukocytosis, or both very closely correlated with tumor growth. Surgical excision of the tumors or regression of tumor mass due to aggressive anticancer drug administration resulted in decreases in leukocyte number, serum calcium level, or both. In contrast, recurrence or regrowth of tumors induced further development of hypercalcemia, leukocytosis, or both. It is therefore likely that humoral factors released by these oral carcinomas are responsible for the hypercalcemia, leukocytosis, or both.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
7/10. Primary squamous cell carcinoma of the thyroid associated with leukocytosis and hypercalcemia.Primary squamous cell carcinoma of the thyroid is an extremely rare, aggressive neoplasm with a uniformly poor prognosis. Described herein is a case of a 66-year-old man with primary squamous cell carcinoma of the thyroid associated with hypercalcemia (13 mg/dL [3.24 mmol/L]) and unexplained leukocytosis (28,400/mm3 [28.4 X 10(9)/L]). The histogenesis of squamous cell carcinoma of the thyroid remains controversial. The associated hypercalcemia and leukocytosis most likely represent a form of paraneoplastic syndrome; possible mechanisms will be discussed in the light of recent studies on tumor-derived mediators.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
8/10. Acute febrile neutrophilic dermatosis (Sweet's syndrome) associated with lymphoma.A case of Sweet's syndrome (acute febrile neutrophilic dermatosis) in a patient in whom lymphoma subsequently developed is presented. The literature concerning Sweet's syndrome in association with malignancy is reviewed. awareness of this potential association is imperative for the early detection of the neoplasm and for the institution of appropriate follow-up care.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
9/10. Bladder carcinoma producing granulocyte colony-stimulating factor: a case report.A 67-year-old man with squamous cell bladder carcinoma showed remarkable leukocytosis (maximum 50,300 per microliter.) for 4 months while the neoplasm recurred and metastasis progressed. The patient died of systemic metastasis within 9 months after cystectomy. Enzyme immunoassay of the serum demonstrated remarkably high levels of granulocyte colony-stimulating factor (4,928 pg./ml.). Immunohistochemical examination with anti-granulocyte colony-stimulating factor monoclonal antibody demonstrated granulocyte colony-stimulating factor production in the metastatic cancer cells in the liver. The expression of the granulocyte colony-stimulating factor gene in the tumor specimens was examined by standard Northern blot analysis. Specific granulocyte colony-stimulating factor transcript was identified in the total ribonucleic acid fraction extracted from a tumor specimen of the peritoneal metastatic lesion. These results indicated that the autonomous production of granulocyte colony-stimulating factor in this bladder carcinoma induced paraneoplastic leukocytosis.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
10/10. Mesenteric tumor emboli manifested as recurrent abdominal pain.Mesenteric tumor emboli have been rarely reported in the literature. Tumors associated with this phenomenon include aortic angiosarcomas, pulmonary neoplasms, Hodgkin's lymphoma, and renal cell carcinoma. In most cases, presentation is dramatic and death is rapid. We present a case of mesenteric tumor emboli from an aortic source that had a more subtle presentation with recurrent abdominal pain and leukocytosis.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
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