1/5. leukoplakia of the anal canal.Two cases of leukoplakia of the anal canal are presented, with illustrations of the typical gross and microscopic appearance. The lesions were asymptomatic, and were discovered by routine rectal examination. Histological findings included hyperkeratosis and acanthosis extending cephalad from the anal verge to the dentate line. Followup after 3 and 15 years revealed no evidence of dysplastic changes, and a review of the literature did not uncover any reported cases with dysplasia or with documented evolution to malignancy. There is little evidence that leukoplakia of the anal canal is premalignant but patients should be followed carefully, since the natural history of this rare lesion is unknown.- - - - - - - - - - ranking = 1keywords = acanthosis (Clic here for more details about this article) |
2/5. Diffuse finely nodular lesions of the esophagus.Double contrast study of the esophagus revealed a variety of diffuse finely nodular lesions, some of which have not been adequately reported. acanthosis nigricans, superficial spreading esophageal cancer, leukoplakia, moniliasis, and esophagitis were found to produce this appearance. Typical cases of the first three diseases are demonstrated and the differential diagnosis discussed.- - - - - - - - - - ranking = 0.22692430019047keywords = nigricans (Clic here for more details about this article) |
3/5. Caustic cicatrization of the pharynx associated with dysphagia and premalignant mucosal changes.Although esophageal strictures with attendant malignant degeneration are well known sequelae of caustic ingestion, fixed pharyngeal structural lesions and development of oral leukoplakia are not well appreciated consequences of such ingestion. We present a patient 12 yr after lye ingestion who displayed rapidly progressive dysphagia suggestive of esophageal carcinoma. Instead, adhesions bisecting the cricopharyngeal inlet and an upper esophageal stricture were found endoscopically. In addition, an area of hypopharyngeal leukoplakia with marked acanthosis, parakeratosis, and dysplasia was noted and resected. The management of this patient's dysphagia and subsequent follow-up for his potentially precancerous oral lesion form the basis of this report.- - - - - - - - - - ranking = 1keywords = acanthosis (Clic here for more details about this article) |
4/5. Laryngeal glycogenic acanthosis presenting as leukoplakia.We report a case of an incidental finding of glycogenic acanthosis of the larynx on autopsy in a 79-year-old man who died of myocardial infarction. The lesion was grossly recognized as a white plaque (leukoplakia) on the subglottic compartment of the left side of the larynx. Histological sections revealed thickened squamous mucosa positive for abundant glycogen on periodic acid-Schiff staining. No epithelial dysplasia was noted. The patient had a history of smoking. This case represents the first report of glycogenic acanthosis involving the larynx. This benign condition should be added to the vast differential diagnosis of leukoplakia in this anatomical location.- - - - - - - - - - ranking = 6keywords = acanthosis (Clic here for more details about this article) |
5/5. Radiological manifestations of oesophageal involvement in acanthosis nigricans.Radiologic features of two cases of acanthosis nigricans with oesophageal involvement are reported. The first case demonstrated diffuse, granular shadows throughout the oesophagus which were difficult to differentiate from oesophageal moniliasis. Another case showed many discrete and tiny elevations resembling pseudopolyposis of the colon. Emphasis is placed on radiological differential diagnosis from moniliasis and leukoplakia of the oesophagus.- - - - - - - - - - ranking = 11.737842905717keywords = acanthosis nigricans, acanthosis, nigricans (Clic here for more details about this article) |