1/26. Unilateral linear lichen planus with mucous membrane involvement.Linear lichen planus is a rare distinctive variant of lichen planus (LP) characterized by a pruritic eruption of lichenoid, violaceous papules in a linear distribution that sometimes assume a Blaschko line pattern. We describe a 33-year-old woman who presented with a 4-month history of a slightly pruritic unilateral linear array of papular lesions on the left side of her neck that were clinically and histologically consistent with linear LP. Two months after the onset of her skin disease she developed typical lesions with a lacy white pattern on the left lateral aspect of her tongue and the left buccal mucosa with a striking predominance for the left side. Clinically the lesions on the patient's neck were similar to lichen striatus or lichenoid epidermal naevus, a variant of linear verrucous epidermal naevus. However, the histological features and the fact that later in the course of her disease the patient developed typical LP of the oral mucosa suggest that this patient has the rare condition of linear LP with unilateral restriction.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
2/26. Erosive mucosal lichen planus: response to topical treatment with tacrolimus.Erosive mucosal lichen planus is a painful and disabling inflammatory skin disease that is highly resistant to topical treatment. We report on six patients with severe recalcitrant erosive mucosal lichen planus who benefited from topical application of tacrolimus ointment. After 4 weeks of treatment, complete resolution was observed in three cases, and substantial improvement was achieved in the other three patients. In these cases, prolonged treatment resulted either in further improvement or in complete healing. All patients reported rapid relief from pain and burning. No severe side-effects were observed.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
3/26. lichen planus pemphigoides with IgG autoantibodies to the 180 kd bullous pemphigoid antigen (type XVII collagen).We describe a 75-year-old patient with pruritic papules on her trunk and extremities, typical of lichen planus, who later experienced subepidermal blisters. These clinical features are consistent with lichen planus pemphigoides. Immunofluorescence of perilesional skin showed linear deposits of C3 along the dermoepidermal junction. Circulating IgG autoantibodies were found to be directed against an epidermal component of the dermoepidermal junction because the patient's serum labeled the epidermal side of 1 mol/L NaCl-split skin. The patient's IgG autoantibodies were directed exclusively against the 180 kd bullous pemphigoid antigen (BPAg2, type XVII collagen) detected in human keratinocyte lysate by Western blot assay. No reactivity was found against the 230 kd bullous pemphigoid antigen, type VII collagen, or the laminin-5 subunits. This study demonstrates that BPAg2 is recognized, not only by bullous pemphigoid sera, but also by lichen planus pemphigoides sera. Our findings attest to the similarity of immunopathology in these two subepidermal blistering skin diseases.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
4/26. Previous tuberculosis, hepatitis c virus and lichen planus. A report of 10 cases, a causal or casual link?We report 10 cases of lichen planus (LP) and chronic liver disease linked to HCV. The mean age was 63.4 /- 5.1 years (range 51-73), five were female; six patients had an established cirrhosis of the liver, as shown by either a liver biopsy or the ultrasonographic and biohumoral evidence. The remaining four patients had chronic hepatitis. Histological examination confirmed the presence of LP: the localization of the dermatosis was restricted to the skin in four patients, to the mucous membranes in five (4 atrophic erosive and one erosive) while the remaining had mucous-cutaneous localization. A type II cryoglobulinemia was demonstrated in two and a type III in one of the patients, while no one had otherwise circulating autoantibodies (anti-nuclear, anti-smooth muscle, anti-liver kidney microsomal type 1 and anti-mitochondrial antigens) such as other etiological factors of liver disease. In six of the patients the history was positive for previous mycobacterium tuberculosis infection. In clinical practice the patients with chronic liver disease and HCV infection can also suffer from severe extrahepatic manifestations, including lichen planus.- - - - - - - - - - ranking = 2.009566128669keywords = dermatosis (Clic here for more details about this article) |
5/26. lichen planus occurring after hepatitis B vaccination: a new case.lichen planus is a pruritic inflammatory dermatosis of unknown origin. An increased prevalence of a wide range of liver disease in lichen planus has been observed by many authors. Most recently, many reports appeared of the occurrence of lichen planus after administration of different types of hepatitis b vaccines. We report one case and briefly review this intriguing observation.- - - - - - - - - - ranking = 2.009566128669keywords = dermatosis (Clic here for more details about this article) |
6/26. ESRD-associated cutaneous manifestations in a hemodialysis population.Cutaneous manifestations occurring in patients with end stage renal disease (ESRD) can indicate systemic problems that have significant morbidity and mortality risks. Skin changes are sometimes a consequence of the disease that caused the renal failure or may be an ESRD manifestation. pruritus is the most prevalent ESRD cutaneous complaint, but its pathogenesis is not understood. The pathophysiology, presentation, and nursing implications of perforating dermatosis, metastatic calcification, polytetraflouroethylene graft infection, and lichen planus are discussed with corresponding case reports.- - - - - - - - - - ranking = 2.009566128669keywords = dermatosis (Clic here for more details about this article) |
7/26. Report of a new case with four skin diseases.A 70 year old man is presented with four distinct skin diseases that were diagnosed concomitantly. lichen planus, vitiligo, lichen sclerosis, and disseminated actinic porokeratosis were all diagnosed clinically and histologically in this man, who was otherwise healthy.- - - - - - - - - - ranking = 5keywords = skin disease (Clic here for more details about this article) |
8/26. Vulvar lichen planus associated with ulcerative colitis. A case report.BACKGROUND: lichen planus (LP) is a common inflammatory dermatosis the diagnosis of which can be very complex when it affects the female genital area exclusively. The condition should be managed by both dermatologists and gynecologists because the association between vulvar LP and other immune-mediated disorders occurs frequently. CASE: Vulvar LP was diagnosed in 37-year-old woman whose past history was significant for ulcerative colitis (UC) since the age of 21. The oral mucosa and skin were completely unaffected, but whitish papules and plaques were seen diffusely on the whole vulvar region, which had become sclerotic and edematous. Microscopic examination of lesional tissue confirmed the diagnosis, showing classic histologic features in spite of the mixed and hypertrophic clinical variant. Oral therapy with cyclosporin at an initial dose of 250 mg/d led to complete remission within 3 months. CONCLUSION: This case is reported on for the rarity of isolated vulvar involvement by LP and for the excellent response to treatment.- - - - - - - - - - ranking = 2.009566128669keywords = dermatosis (Clic here for more details about this article) |
9/26. Lichen striatus in adults or 'adult blaschkitis'?. There is no need for a new naming.BACKGROUND: Lichen striatus (LS) is a well-known acquired linear inflammatory dermatosis. In 1990, Grosshans and Marot introduced the term 'adult blaschkitis' (AB), describing an eruption similar to LS occurring in an adult (adult LS). Does there really exist a new entity or a need for a new naming? OBJECTIVE AND methods: Two new cases of adult LS are described and the data from 16 earlier cases (12 AB and 4 adult LS) are reviewed. RESULTS: The analysis of 18 adult patients with an acquired inflammatory blaschkolinear eruption reveals that females are affected two times as frequently as males. The mean age at onset is 44 years, the mean duration until spontaneous cure 8.7 months. Relapses occur in 27.7%. In 78%, the eruption is localized on the trunk, in 55% on the arms and in 50% on the legs. Multilinearity is found in 100% if the eruption is on the trunk, and 61.5% if it is on the limbs. Neither clinical nor morphological differences exist between AB and adult LS. CONCLUSION: There are no convincing characteristics which justify creating a new name or even a new entity. AB may be the same as LS, a well-known acquired linear inflammatory dermatosis, which--as has been shown now--does not occur so rarely in adults. However, the etiology of this entity remains obscure.- - - - - - - - - - ranking = 4.0191322573379keywords = dermatosis (Clic here for more details about this article) |
10/26. Treatment of gingival lichen planus with a free gingival graft: a case report.lichen planus is an inflammatory dermatosis affecting the skin and mucous membrane. In oral lichen planus, the gingival tissue is often involved. Treatment is symptomatic and depends mostly on the administration of corticosteroids and tranquilizers. This report presents the case of a patient with gingival lichen planus who was treated with free gingival graft. Followup after 3 1/2 years showed that the lesions had completely disappeared.- - - - - - - - - - ranking = 2.009566128669keywords = dermatosis (Clic here for more details about this article) |
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