1/23. Previous tuberculosis, hepatitis c virus and lichen planus. A report of 10 cases, a causal or casual link?We report 10 cases of lichen planus (LP) and chronic liver disease linked to HCV. The mean age was 63.4 /- 5.1 years (range 51-73), five were female; six patients had an established cirrhosis of the liver, as shown by either a liver biopsy or the ultrasonographic and biohumoral evidence. The remaining four patients had chronic hepatitis. Histological examination confirmed the presence of LP: the localization of the dermatosis was restricted to the skin in four patients, to the mucous membranes in five (4 atrophic erosive and one erosive) while the remaining had mucous-cutaneous localization. A type II cryoglobulinemia was demonstrated in two and a type III in one of the patients, while no one had otherwise circulating autoantibodies (anti-nuclear, anti-smooth muscle, anti-liver kidney microsomal type 1 and anti-mitochondrial antigens) such as other etiological factors of liver disease. In six of the patients the history was positive for previous mycobacterium tuberculosis infection. In clinical practice the patients with chronic liver disease and HCV infection can also suffer from severe extrahepatic manifestations, including lichen planus.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
2/23. lichen planus after HBV vaccination in a child: a case report from nepal.vaccination against hepatitis b virus has rarely been associated with lichen planus. We report a case of this kind in a child from nepal. A 12-year-old boy had developed generalized itchy violaceous papules and plaques six weeks after the second dose of hepatitis b virus vaccine. serum HBsAg and HBeAb were negative, but HBsAb was positive. New crops of generalized, similar eruptions developed after the booster dose of vaccine. All the lesions resolved within three months of systemic steroid therapy. There was no recurrence after one year of follow up. awareness of such an association is necessary, especially in children, because vaccination campaigns are increasing.- - - - - - - - - - ranking = 0.4keywords = hepatitis (Clic here for more details about this article) |
3/23. lichen planus, erythema nodosum, and erythema multiforme in a patient with chronic hepatitis c.After identification of the hepatitis c virus (HCV) in 1989, evidence was established supporting its role in the pathogenesis of a number of cutaneous diseases. This evidence ranges from mere epidemiologic associations, such as lichen planus, to molecular biological investigations that have identified the virus in the pathologic tissues of cutaneous vasculitis, vasculitis with mixed cryoglobulinemia, and porphyria cutanea tarda. We describe a 52-year-old man who was diagnosed with chronic hepatitis c, preceding the appearance of lichen planus, erythema nodosum, and erythema multiforme that coincided with the reactivation of viral replication.- - - - - - - - - - ranking = 1.2keywords = hepatitis (Clic here for more details about this article) |
4/23. lichen planus occurring after hepatitis B vaccination: a new case.lichen planus is a pruritic inflammatory dermatosis of unknown origin. An increased prevalence of a wide range of liver disease in lichen planus has been observed by many authors. Most recently, many reports appeared of the occurrence of lichen planus after administration of different types of hepatitis b vaccines. We report one case and briefly review this intriguing observation.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
5/23. lichen planus following hepatitis B vaccination in an African girl.lichen planus is a papulosquamous disorder with distinctive clinical features. Until now the aetiology has been largely unknown, however, several postulations have been proposed. The immunopathogenic basis has been most favoured. We report a case of a 13-year-old girl who presented with lichen planus after receiving the second dose of hepatitis b virus (HBV) vaccination. This report, similar to earlier reports, appears to support the immunopathogenic basis of lichen planus.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
6/23. lichen planus and leukocytoclastic vasculitis induced by interferon alpha-2b in a subject with HCV-related chronic active hepatitis.lichen planus (LP) has been reported in association with chronic active hepatitis, primary biliary cirrhosis and other chronic liver diseases. The occurrence of LP in persons with hepatitis c virus (HCV) was reported by Robert et al., and the possible relationship between LP and hepatitis virus has also been supported by cases of LP following hepatitis B vaccination. Exacerbation or appearance of LP during the treatment of chronic hepatitis c, lymphoproliferative diseases and melanoma with alpha-interferon (IFN-alpha) and improvement of these diseases after discontinuation of this drug indicate that IFN-alpha may possibly induce LP. We present a case of cutaneo-mucous LP in a woman with chronic active hepatitis treated with IFN-alpha and in whom local leukocytoclastic vasculitis was induced by the intradermal injection of a very low dose of IFN-alpha.- - - - - - - - - - ranking = 2keywords = hepatitis (Clic here for more details about this article) |
7/23. Hepatocellular carcinoma and lichen planus: report of two cases.A patient with lichen planus (LP) who developed a hepatocellular carcinoma as a consequence of a postviral chronic hepatitis is described. Its possible noncoincidental association with LP is discussed on the basis of a recent large case-control study in which the association of LP with chronic, possibly postviral, liver disorders has been confirmed. In the same study 1 case out of 577 LP patients was found to have hepatocellular carcinoma versus none of the 1,031 controls, a prevalence which is higher than expected in a western population.- - - - - - - - - - ranking = 0.2keywords = hepatitis (Clic here for more details about this article) |
8/23. The relation between lichen planus and hepatitis c: a case report.A case of simultaneous occurrence of lichen planus (LP) and hepatitis c in the same patient is presented. The patient had received treatment with interferon alpha for her chronic liver disease, and the association between LP, hepatitis c and interferon alpha treatment is discussed.- - - - - - - - - - ranking = 1.2keywords = hepatitis (Clic here for more details about this article) |
9/23. lichen planus and the vulvovaginal-gingival syndrome.lichen planus is a dermatologic disease that affects both skin and mucosa. Here we report five cases of lichen planus that presented as the oral component of the vulvovaginal-gingival syndrome. Four of the cases were associated with biopsy-proven oral lichen planus, and all five patients had oral lesions that clinically resembled lichen planus. Three patients were taking medications that are associated with lichenoid drug reactions; four patients were postmenopausal; and all five patients had desquamative vulvovaginitis. Clinicians may see these patients when they show persistent signs and symptoms of oral lichen planus. We report five case histories and review the 127 cases found in the literature to make the practicing clinician aware of this unusual clinical entity. The hepatitis c virus association and drug-induced lichenoid mucositis are topics that are addressed. In addition, clarification of the issues surrounding the premalignant potential of oral lichen planus is provided with evidence, rationale, and data from the literature to support the position that true oral lichen planus has no inherent predisposition to become malignant.- - - - - - - - - - ranking = 0.2keywords = hepatitis (Clic here for more details about this article) |
10/23. lichen planus induced by hepatitis B vaccination: a new case and review of the literature.In May 1996, as part of his routine antihepatitis B (hepB) vaccination plan, a 28-year-old HbsAg-negative man, hospital worker, received his first dose (20 microg) of a recombinant vaccine (EngerixB-B, Smith Kline and Beecham, belgium), administered via deltoid injection. The patient was otherwise healthy and taking no medication. Thirty days after the 2nd booster dose, several pruritic, polygonal, purple, papules appeared on the volar aspect of the patient's wrists. New lesions gradually spread to the arms and trunk (Fig. 1). The clinical diagnosis of lichen planus (LP) was confirmed by histology, which revealed hyperorthokeratosis, hypergranulosis, vacuolar degeneration of the basal layer cells and a dense, band-like lymphocytic infiltrate in the superficial dermis. The disease started to heal after treatment with topical clobetasol propionate 0.05% and sun exposure during the following summer. Five days after the 3rd booster dose, in November 1996, the dermatosis relapsed on the forearms, trunk, and legs. On that occasion, routine laboratory tests, including a complete blood count, blood chemistry and liver function tests, were within normal limits. Screening serologic tests for autoantibodies including antinuclear antibodies, antidouble-stranded dna, anti-SS-A, anti-SS-B and anti-Sm were all negative. As a result of the inadequate levels of antihepatitis B antibodies, less than 10 IU/l in May 1998, in a high-risk patient who was frequently exposed to blood and its products, an additional booster dose was performed. Three days later a new recurrence of disseminated lichen planus occurred. The patient was successfully treated with prednisone 1 mg/kg/day for 2 weeks. There was no recurrence the following year.- - - - - - - - - - ranking = 1.2keywords = hepatitis (Clic here for more details about this article) |
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