1/5. Partial lipodystrophy in a patient with systemic lupus erythematosus.A 54-year-old woman developed partial lipodystrophy on the left side of her face. She had been suffering from systemic lupus erythematosus (SLE) since 1985 when she was 45 years old, and she had been treated with 30 mg/day of oral prednisolone as an initial dose. Partial lipodystrophy appeared on her left lower jaw in 1994 when the SLE was inactive, and the dose of prednisolone was reduced to 5 mg/ 3 days. Gradually, the lipodystrophy spread toward her left cheek and her left forehead without any preceding skin symptoms. Histological examination showed a loss of fat tissue and mild lymphocytic infiltrations mainly around cutaneous appendages and vessels in the dermis and subcutaneous tissue. The dose of prednisolone was increased to 10 mg/day and the lesions stopped spreading. Such partial lipodystrophy is distinct from lipoatrophy of lupus profundus.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
2/5. The immunohistochemical observation of somatostatin-like and avian pancreatic polypeptide-like immunoreactivity in certain cellular elements of diabetic lipodystrophic skin.somatostatin-like and avian pancreatic polypeptide-like immunoreactivities were found to occur within certain cellular elements of the dermis of a patient having diabetic lipodystrophic skin lesions. No specific immunofluorescence could be seen in the epidermis.- - - - - - - - - - ranking = 2keywords = dermis (Clic here for more details about this article) |
3/5. Lipodystrophia centrifugalis abdominalis juvenilis.8 Korean children exhibited well-defined depressed lesions of the skin accompanied by slight redness of the surrounding area. First these lesions appeared in the inguinal area and then spread peripherally to the navel region and the ipsilateral vulval area. In these 8 cases, 7 occurred in girls and 1 in a boy. The age of onset ranged from 2 to 9 years. biopsy specimens taken from the well-depressed area showed a decrease in or absence of, subcutaneous fat and a mild inflammatory infiltrate of lymphocytes and histiocytes in the lower dermis and subcutis. These 8 cases are the first, to our knowledge, to be reported outside japan and considering the age of onset of the dermatosis it is not confined to infants. Therefore, we would like to describe this entity under the title of lipodystrophia centrifugalis abdominalis juvenilis instead of lipodystrophia centrifugalis abdominalis infantilis.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
4/5. Facial contour reconstruction in lipodystrophy using a double paddle dermis-fat radial forearm free flap.Facial lipodystrophy is a relatively rare disease and very little has been reported concerning the reconstruction of this facial deformity compared with Romberg's disease. In this article we report a new surgical procedure using a double paddle radial forearm dermis--fat free flap. By using this unique flap, we could reconstruct soft tissue defects on both cheeks in a one-stage operation using one flap. In the previous conventional procedure, two flaps are required for the reconstruction of bilateral defects on the face. Therefore, we also made a comparison between our flap and the conventional flap with regard to their advantages and disadvantages. Although this is a limited experience, we think using this flap is a preferable method of treating facial lipodystrophy.- - - - - - - - - - ranking = 5keywords = dermis (Clic here for more details about this article) |
5/5. Pseudoxanthomatous lesions with membranocystic changes of collagen fibers in an SLE patient receiving long-term steroid treatment.We report a 50-year-old Japanese woman with a 3-year history of systemic lupus erythematosus treated with prednisolone, who had diffuse plane yellowish macules mainly on the upper arm. The lesion was clinically diagnosed as diffuse plane xanthomatosis. However, the histopathological findings from both the yellowish macules and the normal-appearing skin revealed a heavy degeneration of collagen fibers with membranocystic structure throughout the entire dermis and the collagenous septum of the subcutaneous tissue. Ultrastructurally, the membranocystic structure was not due to the degenerative change of fat cells as seen in membranous lipodystrophy but was caused by the degenerative change of collagen fibers with fat deposit.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |