1/10. Pulmonary toxoplasmosis in bone marrow transplant recipients: report of two cases and review.toxoplasma gondii may cause disseminated disease in bone marrow transplant (BMT) recipients. Pulmonary toxoplasmosis in BMT patients is rarely described. mortality rates of >90% have been previously reported. Since pulmonary toxoplasmosis is extremely difficult to diagnose, it is very often detected only at autopsy. Two cases of pulmonary toxoplasmosis in BMT recipients that were diagnosed by visualization of T. gondii tachyzoites in bronchoalveolar lavage fluid and by a new semi-nested PCR method amplifying 18S rRNA from bronchoalveolar lavage fluid are presented, and the literature on pulmonary toxoplasmosis in BMT patients is reviewed.- - - - - - - - - - ranking = 1keywords = toxoplasmosis (Clic here for more details about this article) |
2/10. toxoplasma pneumonitis: fatal presentation of disseminated toxoplasmosis in a patient with AIDS.toxoplasma gondii infection is an uncommon cause of pneumonitis in patients with acquired immune deficiency syndrome (AIDS). We report a case of fatal pulmonary toxoplasmosis, which clinically resembled pneumocystis carinii pneumonia (PCP). Conventional diagnostic methods for toxoplasmosis lack sensitivity. bronchoscopy and histological evaluation of transbronchial biopsy specimens failed to identify the infecting organism. At autopsy there was evidence of disseminated infection.- - - - - - - - - - ranking = 0.75keywords = toxoplasmosis (Clic here for more details about this article) |
3/10. Disseminated toxoplasmosis after bone marrow transplantation: high-resolution CT appearance.A 16-year-old female patient, who had undergone bone marrow transplantation 35 days earlier, presented with dry cough, dyspnea, and fever for 4 days. Chest radiography showed poorly-defined bilateral opacities. High-resolution CT revealed bilateral ground glass opacities with superimposed septal thickening and intralobular linear opacities. Laboratory results were nonspecific and empiric treatment with multiple drugs was initiated. The patient had no response to therapy and died 12 days after the admission. At autopsy the patient had disseminated toxoplasmosis with involvement of the central nervous system, myocardium, bone marrow, and lungs.- - - - - - - - - - ranking = 0.625keywords = toxoplasmosis (Clic here for more details about this article) |
4/10. Disseminated toxoplasmosis with pulmonary involvement after heart transplantation.We report a case of pulmonary toxoplasmosis after heart transplant despite the prophylactic anti-toxoplasmic treatment that was given but was not sufficient to prevent toxoplasmosis. However, the patient survived thanks to early diagnosis confirmed by polymerase chain reaction on blood and by serological techniques, and early treatment.- - - - - - - - - - ranking = 0.75keywords = toxoplasmosis (Clic here for more details about this article) |
5/10. Fatal pulmonary microsporidiosis due to encephalitozoon cuniculi following allogeneic bone marrow transplantation for acute myelogenous leukemia.microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of microsporidiosis have been reported during the past 20 years, in patients with hiv/AIDS, while only relatively rare cases have been described in immunocompetent individuals. However, microsporidia infections are being increasingly reported in patients following solid-organ transplanation, where the main symptom has been diarrhea. The authors report the first case of pulmonary microsporidial infection in an allogeneic bone marrow transplant recipient in the united states and only the second case in the world. The patient, with a history of hodgkin disease followed by acute myelogenous leukemia received a T-cell-depleted graft, but succumbed to respiratory failure 63 days post transplantation. An open lung biopsy, taken just before death, was originally thought to show toxoplasmosis. The correct diagnosis of microsporidiosis was made postmortem by light and electron microscopy. dna polymerase chain reaction analysis confirmed the diagnosis and furthermore revealed it to be the dog strain of the microsporidia species encephalitozoon cuniculi. Although to date rarely diagnosed, microsporidial infection should also be considered in the differential diagnosis of, e.g., unexplained pulmonary infection in bone marrow transplant patients.- - - - - - - - - - ranking = 0.125keywords = toxoplasmosis (Clic here for more details about this article) |
6/10. Case report: fatal pulmonary toxoplasmosis following chemotherapy.A 41-year-old woman with acute myelomonocytic leukemia in remission died of a rapidly progressive necrotizing pneumonia while in the recovery phase following consolidation chemotherapy. autopsy revealed disseminated toxoplasmosis. Although this syndrome has been well described to present as a neurologic complication in certain immunocompromised patients, it is rare in acute leukemia, and non-neurologic presentations are even more unusual. This case emphasizes the need to be suspicious of toxoplasmosis in immunocompromised patients even in the absence of neurologic signs or symptoms.- - - - - - - - - - ranking = 0.75keywords = toxoplasmosis (Clic here for more details about this article) |
7/10. Pulmonary toxoplasmosis in AIDS.In contrast to toxoplasmosis in non-AIDS immunocompromised hosts, AIDS patients rarely have been reported to be infected at extra-CNS sites. We report the case of a 45-year-old homosexual male with AIDS who presented with pneumonitis caused by toxoplasma gondii following a previous illness consistent with CNS toxoplasmosis.- - - - - - - - - - ranking = 0.75keywords = toxoplasmosis (Clic here for more details about this article) |
8/10. Small nodular pattern in the lungs due to opportunistic toxoplasmosis.We report a patient with widespread nodular densities in the lungs complicating massive infestation by toxoplasma gondii in an immunologically compromised host.- - - - - - - - - - ranking = 0.5keywords = toxoplasmosis (Clic here for more details about this article) |
9/10. lung toxoplasmosis after HLA mismatched bone marrow transplantation.We report a clinically isolated toxoplasma pneumonitis in a child treated by HLA haplo-mismatched BMT. Conditioning consisted of TBI, cytarabine and melphalan. The BM graft was T-depleted and the boy received iv moAb antiLFA1 and antiCD2. The clinical course of pneumonitis was characterised by an early onset (day 28) and a rapidly overwhelming course. Donor and recipient had pre-graft IgG Ab against toxoplasma without IgM. These Abs had completely disappeared from the serum of the patient at the time of pneumonitis. PCR amplification detected the B1 gene of toxoplasma gondii in the patient's PBMC from day 28.- - - - - - - - - - ranking = 0.5keywords = toxoplasmosis (Clic here for more details about this article) |
10/10. Pulmonary toxoplasmosis after allogeneic bone marrow transplantation: case report and review.We report an isolated case of toxoplasma pneumonitis in a 27-year-old man. This acute infection occurred after induction chemotherapy for AMLo relapsing 3 years post-allogeneic BMT. The detection of toxoplasma gondii in the bronchoalvolar lavage (BAL), by culture in fibroblast cell line MRC5 enabled us to make the diagnosis. pyrimethamine and sulfadiazine were effective.- - - - - - - - - - ranking = 0.5keywords = toxoplasmosis (Clic here for more details about this article) |
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