1/32. Extrahepatic manifestations of chronic hepatitis c.A by-product of increasing experience with patients infected with the hepatitis c virus is the awareness of a variety of extrahepatic syndromes that seem to be associated with HCV infection. Recent investigations into the relationship between the hepatitis c virus and human cells, particularly lymphocytes, have resulted in possible pathophysiological interactions that may begin to explain some of the extrahepatic manifestations of hepatitis c virus infection. In this review, we will discuss some of the potential interactions from both pathophysiological and clinical viewpoints.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
2/32. Two cases of lymphadenopathy with liver dysfunction due to mycoplasma pneumoniae infection with mycoplasmal bacteraemia without pneumonia.We present two cases of unusual manifestations of mycoplasma pneumoniae infection: lymphadenopathy with liver dysfunction without pneumonia. One was diagnosed as an infectious mononucleosis-like syndrome and the other as Kawasaki disease. polymerase chain reaction successfully detected mycoplasma pneumoniae dna using blood samples. mycoplasma pneumoniae can be included in the panel of aetiological agents in patients with lymphadenitis and hepatitis even in the absence of pneumonia.- - - - - - - - - - ranking = 0.14285714285714keywords = hepatitis (Clic here for more details about this article) |
3/32. Generalized lymphadenopathy as a marker of ongoing inflammation in prolonged cholestatic hepatitis a.Extrahepatic manifestations of hepatitis a are very unusual. We describe a case of prolonged cholestatic hepatitis a in a patient with generalized lymphadenopathy. With normalization of transaminases, there was an accompanying reduction in size of these lymph nodes. Lymphadenopathy reflects ongoing hepatic inflammation in prolonged cholestatic hepatitis a.- - - - - - - - - - ranking = 1keywords = hepatitis (Clic here for more details about this article) |
4/32. Development of multiple abscesses in an hiv/TB co-infected patient after initiation of antituberculous and highly active antiretroviral therapy.Since the use of Highly Active Antiretroviral Therapy (HAART) for hiv infection, there have been increasing reports of systemic manifestations of immune restoration. This new clinical syndrome among hiv-infected patients is associated with underlying co-infections with mycobacteria, cytomegalovirus, hepatitis b and C infections, etc.... We report on an hiv/tuberculosis (TB) co-infected patient who developed an immune restoration inflammatory syndrome after initiation of HAART and anti-TB treatment. She developed fever, large abscesses and pleural and peritoneal effusions. Systemic symptoms decreased during corticosteroid treatment, but abscesses only disappeared 8 months after the start of the anti-TB treatment.- - - - - - - - - - ranking = 0.14285714285714keywords = hepatitis (Clic here for more details about this article) |
5/32. Elevated interleukin-6 and gamma-globulin during interferon therapy of hepatitis B.A 49-yr-old man with chronic hepatitis b manifested hypergammaglobulinemia, lymphadenopathy, and a high serum interleukin-6 level following treatment with recombinant human alpha-interferon. One month later, when the patient was treated with natural beta-interferon, serum levels of interleukin-6 and gamma-globulin increased again. The serum gamma-globulin decreased to the pretreatment level after discontinuation of interferon therapy. The serum alanine aminotransferase level remained normal for 6 months. In this case, hypergammaglobulinemia and lymphadenopathy, as well as the elevated serum interleukin-6 level, were considered to be signs of highly enhanced humoral immunity related to alpha- and beta-interferon therapy.- - - - - - - - - - ranking = 0.71428571428571keywords = hepatitis (Clic here for more details about this article) |
6/32. coxiella burnetii: an unusual ENT pathogen.coxiella burnetii, the causative agent of q fever, is a prevalent zoonotic disease manifestating usually as atypical pneumonia or hepatitis. We describe 2 cases of serologically proven infection by coxiella burnetii whose primary manifestations arose from the upper respiratory tract and were initially referred to the ear, nose, and throat (ENT) department. This is the first related report in medical literature. A 20-year-old woman with fever, bilateral tonsillitis, lymphadenopathy, and mild aminotransferase elevation, and a 30-year old man with spiking fever and laryngitis are presented. diagnosis in both cases was achieved through evolving serological response to coxiella burnetii. The importance of including the pathogen in the differential diagnosis of ENT patients, in assorted epidemiological settings, and the significance of the proper antibiotic selection are further discussed.- - - - - - - - - - ranking = 0.14285714285714keywords = hepatitis (Clic here for more details about this article) |
7/32. Tumour-like inflammatory abdominal conditions in children.The presence of a tumour, poor general condition, features of anaemia, increased erythrocyte sedimentation rates and imaging suggesting malignancy were the common features in 4 different tumour-like abdominal conditions that are extremely rare in childhood. These conditions included: extensive retroperitoneal tumour with rib involvement that turned out to be an inflammatory lesion caused by actinomyces in a 12-year-old girl; multi-loculated tumour of the mesentery/ovary caused by mesenteric lymphadenopathy in the course of a salmonella enteritidis infection in a 2.5-year-old girl; tumour of the VII - VIII hepatic segments that turned out to be the focus of granuloma in the course of lambliasis in a 5.5-year-old boy with a history of purulent neck lymphadenopathy and a final suspicion of immunocompromise; and a multi-loculated tumour of the small pelvis and inguinal area that turned out to be an abscess of the iliopsoas muscle in a 16-year-old boy. Apart from the imaging, the lesions required cytological examination of the material harvested by fine-needle biopsies (liver tumour) or histopathological investigations (retroperitoneal tumour, mesenteric/ovarian tumour, liver tumour and--on second surgery--the pelvic tumour) and/or bacteriological examination (all cases), serological examination (liver tumour and mesenteric/ovarian tumour), protozoal investigation (liver tumour), and measurement of AFP levels (mesenteric/ovarian tumour). Surgical treatment (retroperitoneal tumour, mesenteric/ovarian tumour and tumour of the small pelvis) and guided antibiotic therapy (all cases including 15 weeks of antibiotics in the first case) allowed complete recovery in 3 patients (actinomycosis, mesenteric lymphadenopathy, abscess of the iliopsoas muscle). Antibiotic and antiprotozoal therapy cured the granulomatous hepatitis; however this patient tended to develop severe right-sided pleural/pulmonary changes (the child was referred for further diagnosis with suspicion of immunocompromise).- - - - - - - - - - ranking = 0.14285714285714keywords = hepatitis (Clic here for more details about this article) |
8/32. sarcoidosis occurring after interferon-alpha therapy for chronic hepatitis c: report of two cases.We report two patients who were diagnosed with sarcoidosis after receiving interferon (IFN)-alpha therapy for chronic hepatitis c, and conduct a review the relevant literature. The first patient was a 52-year-old female who developed multiple subcutaneous nodules 2 months after finishing IFN-alpha therapy. A skin biopsy from subcutaneous nodules on the right elbow joint revealed sarcoid granulomata. These lesions resolved spontaneously 4 months later. The second patient, a 57-year-old male, developed bilateral hilar and mediastinal lymph node enlargement 2 years after finishing IFN-alpha 2a therapy. A transbronchial lung biopsy demonstrated sarcoid granulomata. In addition, he had uveitis and left ulnar nerve involvement. His eye and nerve involvement gradually improved over 20 months. It is feasible that IFN therapy has been a trigger for sarcoidosis in these patients.- - - - - - - - - - ranking = 0.71428571428571keywords = hepatitis (Clic here for more details about this article) |
9/32. sarcoidosis caused by interferon therapy.Interferon alpha (IFN-alpha) is an immunomodulator that is used as an antiviral agent in active chronic viral hepatitis c. IFN therapy can cause an induction or exacerbation of sarcoidosis. Although several reports in the gastroenterology literature have suggested an association between IFN therapy and sarcoidosis, this association has rarely been described elsewhere. A 47-year-old woman developed sarcoidosis after cessation of treatment with IFN and ribavirin for chronic hepatitis c. Her sarcoidosis showed liver, pulmonary and skin involvement. She continues to be monitored regularly in the Department of Pulmonary Diseases without steroid therapy. Her sarcoidosis improved spontaneously. We conclude that patients should be monitored for sarcoidosis during and after IFN therapy.- - - - - - - - - - ranking = 0.28571428571429keywords = hepatitis (Clic here for more details about this article) |
10/32. Atypical American visceral leishmaniasis caused by disseminated Leishmania amazonensis infection presenting with hepatitis and adenopathy.Leishmania amazonensis is widely recognised as a cause of cutaneous leishmaniasis in latin america, but it can also disseminate to produce atypical visceral leishmaniasis with hepatitis and lymphadenopathy. The patient, an 8-year-old Brazilian boy, presented with a febrile illness and hepatosplenomegaly, elevated liver enzymes and generalised adenopathy. Serological tests using antigens of L. chagasi, the typical cause of visceral leishmaniasis in latin america, were inconclusive. Leishmania amazonensis was eventually isolated in a culture of a lymph node. The patient recovered fully after treatment with meglumine antimoniate. As this case illustrates, L. amazonensis produces a spectrum of disease that includes atypical American visceral leishmaniasis with evidence of hepatocellular injury and generalised lymphadenopathy.- - - - - - - - - - ranking = 0.71428571428571keywords = hepatitis (Clic here for more details about this article) |
| | Next -> |