1/3. Primary effusion lymphoma in an hiv-negative patient with no serologic evidence of Kaposi's sarcoma virus.Primary effusion lymphoma (PEL) is a newly described high-grade B cell lymphoma which develops in association with Kaposi's sarcoma-associated herpesvirus (KSV) in human immunodeficiency virus (hiv)-infected individuals. We hereby describe a very unusual presentation of PEL that developed in the abdominal cavity of an hiv negative, KSV negative patient with a 1-year history of refractory ascites due to alcohol-related liver cirrhosis. Possible factors aiding lymphomagenesis in the cirrhotic state are discussed.- - - - - - - - - - ranking = 1keywords = aid (Clic here for more details about this article) |
2/3. Large-cell "mixed-phenotype" lymphoma in AIDS. Identification of a CD5-expressing subset of B-cell non-Hodgkin's lymphoma.We have characterized cells from an AIDS-associated non-Hodgkin's lymphoma (NHL). We found a malignant CD5 B cell (approximately three-fourths of cells), with the balance of cells comprised of T cells having an activated phenotype. The lymphoma was unusual, in that all cells bear "T-lineage" markers, CD3 and CD5, and "B-lineage" markers, CD19 and CD20. Thus, conventional immunohistologic techniques were insufficient to type this mixture of cells; single-cell analysis was required. These "mixed-phenotype" lymphomas may occur frequently in AIDS-associated NHL. Our results show striking similarity to those obtained in the analysis of certain murine CD5 B-cell lymphomas, suggesting that the study of lymphomagenesis in the mouse may aid in the understanding of AIDS-associated NHL.- - - - - - - - - - ranking = 1keywords = aid (Clic here for more details about this article) |
3/3. Secondary pleural involvement by an AIDS-related anaplastic large cell (CD30 ) lymphoma simulating metastatic adenocarcinoma.We report a patient with acquired immunodeficiency syndrome with secondary pleural and pulmonary involvement by a CD30 anaplastic large cell lymphoma (ALCL) that morphologically simulated metastatic adenocarcinoma. We describe the morphologic findings in order to heighten awareness that CD30 ALCL may mimic metastatic adenocarcinoma in a body fluid or bronchial brushing and should be considered in the differential diagnosis. Primary body cavity based (PCBC) AIDS-related lymphoma is a relatively newly described disease entity with morphologic features bridging ALCL and large cell immunoblastic lymphoma with a CD30 null immunophenotype. A morphology mimicking adenocarcinoma has not been previously described in this entity but should be considered in a patient with AIDS presenting exclusively with a serous effusion. Appropriate immunoperoxidase staining should aid in these differential diagnoses.- - - - - - - - - - ranking = 1keywords = aid (Clic here for more details about this article) |