1/13. An unusual renal tumour.Primary renal lymphoma is a rare disease. The basis for diagnosis of this entity has been described and its existence is widely accepted. Localized deposition of amyloid is also a rare phenomenon. A case of primary lymphoma with localized amyloid deposition is reported here.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
2/13. Primary central nervous system lymphoma and subcutaneous metastases.Primary central nervous system lymphoma (PCNSL) is a rare disease with a poor prognosis. It usually remains confined to central nervous system (CNS). Reports of metastases outside of the CNS are rare. We report a patient with well-documented PCNSL who responded to treatment, but subsequently developed a histologically confirmed subcutaneous metastasis to the left leg without local failure.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
3/13. Prostatic adenocarcinoma masquerading as lymphoma and presentation with axillary-subclavian vein thrombosis.Axillary and/or subclavian vein thrombosis is a relatively rare disease, constituting about 2% of all cases of deep venous thrombosis (DVT). We report on a patient who presented with axillary-subclavian vein thrombosis and had metastatic prostatic adenocarcinoma.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
4/13. Uterine adenomyoma with lymphoid infiltration simulating lymphoma.BACKGROUND: Uterine leiomyoma with lymphoid infiltration is a rare disease that simulates malignant lymphoma with only nine cases reported to date. We describe the first case of uterine adenomyoma with lymphoid infiltration simulating lymphoma. CASE: The specimen resected from a 30-year-old Chinese woman was a well-defined firm nodule measuring 5 x 5.5 x 5.5 cm. The cut surface was similar to that of adenomyoma, which contained dark brown spots and a cyst. Microscopically, the tumor comprised smooth muscle cells intermixed with many lymphocytes. Many lymphoid follicles were present, just locating beside one side of thin-walled blood vessels and protruding into the vessels. Endometrial-type glands and stroma were visible in the tumor. CONCLUSION: We describe the first case of uterine adenomyoma with lymphoid infiltration simulating lymphoma.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
5/13. Neurological presentation of intravascular lymphoma: report of two cases and discussion of diagnostic challenges.About a third of patients with intravascular lymphoma (IVL) present to the neurologist with symptoms mimicking thromboembolic events. Diagnosis is difficult, and often made postmortem. As remission may be induced in almost half of patients with combination chemotherapy, early diagnosis of this rare disease is essential. We report two cases of IVL. A 62-year-old male presented with hyperacute myelopathy followed by cortical ischaemic events. The diagnosis was reached with frontal cortical and meningeal biopsy. A 56-year-old female had symptoms of transient ischaemic events, subacute dementia, weight loss and fever. As the disease progressed, she developed nephrotic syndrome and thrombocytopenia. Diagnosis was made postmortem. Our cases illustrate that IVL should be considered in the differential diagnosis of cerebral and systemic vasculitis and subacute bacterial endocarditis. literature suggests IVL can also mimic Creutzfeld-Jakob disease and paraneoplastic encephalomyelitis.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
6/13. Intravascular lymphoma and thyroid gland.Intravascular lymphoma (IVL) is a rare disease characterized by the proliferation of neoplastic cells in the small blood vessels that frequently goes undiagnosed until the time of autopsy. The neoplastic cells are usually of B-cell origin. The clinical course was examined to determine factors that would facilitate antemortem diagnosis. IVL is observed with clinical, histopathological and immunohystochemical methods. This is a unique case because the thyroid gland is a rare place for IVL. Accent is given on immunohystochemical methods and tissue biopsy in the differential diagnosis of IVL when nervous system and thyroid gland dysfunction occur This report indicates that micro-ecosystem of multinodular goitrous might influence the expression of chemokines and/or adhesion moleculs on endothelial and lymphoma cells, leading to heavy infiltration of thyroid gland. Concurrently, that may guide the physician to tissue biopsy facilitating antemortem diagnosis and institution of appropriate therapy.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
7/13. lymphoma of the thyroid. Report of five cases and review.Thyroid lymphoma is a rare disease seen most commonly in elderly women and associated with Hashimoto's thyroiditis. Five cases of thyroid lymphoma seen and treated at Hahnemann University Hospital between 1979 and 1988 are retrospectively reviewed. All patients underwent a staging workup, including chest radiograph, intravenous pyelography, abdominal/pelvic computed tomogram (CT) scan and/or lymphangiogram, and bone marrow. An extensive review of the literature is presented. risk factors for thyroid lymphoma are discussed, enabling the clinician to differentiate thyroid lymphoma from thyroid carcinoma. thyroidectomy may be indicated in a small number of cases, provided that the patient has disease localized within the thyroid such that total gross resection can be achieved. It is proposed that patients with bad prognostic factors may benefit from the administration of chemotherapy initially before or after radiotherapy rather than using chemotherapy as salvage therapy. Irradiating the patient to the neck and mediastinum to 40 Gy, in 4-5 weeks, is recommended, except possibly for tumor that is extremely well localized in the neck. Finally, the necessity of a full staging work-up, including lymphangiogram and/or abdominal/pelvic CT is emphasized.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
8/13. Ofuji papuloerythroderma. Report of a case with T cell skin lymphoma and discussion of the nature of this disease.This report concerns a white woman with characteristic manifestations of Ofuji papuloerythroderma. This erythroderma results from a coalescence of papular sheets that completely spare skin folds. This rare disease is associated with high blood eosinophilia. In this case superficial lymph nodes appeared a few months later and peripheral T cell nonepidermotropic skin lymphoma occurred, which raises questions as to the nosologic implications of papuloerythroderma.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
9/13. Primary lymphoma of the breast.Four cases of lymphoma of the breast are described seen over a period of 2 years amongst 362 cases of breast carcinoma and one of carcinosarcoma. All four were diffuse non-Hodgkin's lymphomas, two of IgM-Kappa secreting follicle centre cell and two of histiocyte origin. Routine histological and enzyme histochemical methods were unhelpful but the application of a panel of antisera for the demonstration of immunoglobulin heavy and light chains, lysozyme, alpha-1-antitrypsin as well as carcinoembryonic antigen and epithelial membrane antigen, enabled a confident diagnosis to be made. Primary lymphoma of the breast may not be a rare disease and the possibility exists that it is misdiagnosed as anaplastic carcinoma as indeed two of these cases were on the initial biopsies. Correct diagnosis is essential so that appropriate treatment may be applied.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
10/13. Successful treatment of recurrent primary central nervous system lymphoma with high-dose methotrexate.Primary central nervous system (CNS) lymphoma is a rare disease, usually resistant to therapy. In the case presented, a 51-year-old woman with documented primary cerebellar CNS lymphoma, lymphoplasmacytoid type, underwent surgical resection and whole brain irradiation and then recurred within the CNS. Treatment with 17 courses of high-dose methotrexate resulted in complete disappearance of the tumor and clearing of all neurologic signs and symptoms. She is now free of disease 12 months after beginning chemotherapy. The potential usefulness of systemic anti-metabolites for treatment of CNS lymphoma, primary or disseminated, is discussed.- - - - - - - - - - ranking = 1keywords = rare disease (Clic here for more details about this article) |
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