1/53. Treatment of central giant cell granuloma of the jaw with calcitonin.Giant cell granuloma of the jaw is a benign lesion that may cause local destruction of bone and displacement of teeth. The common therapy is curettage or resection, which may be associated with loss of teeth and, in younger patients, loss of dental germs. An alternative treatment has recently been introduced, in which patients receive a daily dose of calcitonin. Four patients who have been treated with calcitonin in various concentrations for at least 1 year are reported. In all patients, complete remission of the giant cell granuloma was observed, without signs of recurrence. The working mechanism of calcitonin is discussed, as are length of treatment and optimal dose.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/53. Preservation of the dentition following removal of a central giant cell granuloma: a case presentation.Clinical and radiographic presentation of a child with central giant cell granuloma in the early mixed dentition and a suggested conservative management technique for preserving the developing dentition is presented.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
3/53. Foreign body granuloma following placement of hard tissue replacement material: a case report.The placement of grafting material in extraction sites for ridge preservation is an increasingly common practice among clinicians. This is a case report of a patient presenting with a symptomatic, foreign body granuloma following the placement of hard tissue replacement (HTR) in extraction sockets. The surgical specimen revealed numerous histiocytes and foreign body type giant cells. The grafting material was surgically removed and the patient's symptoms were alleviated. Although biocompatibility of HTR has previously been shown, specific applications may be contraindicated or some patients may exhibit sensitivity to this material.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
4/53. Brown tumour of hyperparathyroidism in the mandible associated with atypical parathyroid adenoma.The brown tumour of hyperparathyroidism is a localized bone tumour and an uncommon manifestation of hyperparathyroidism. A 27-year-old woman presented with a mandibular 8 x 10 cm solid mass diagnosed as central giant cell granuloma. Chemical blood analysis revealed increased serum calcium levels of 12.46 mg/dL and the parathyroid hormone level was 124 pg/dL. The patient underwent surgery with removal of a parathyroid mass. Histologically, this parathyroid tissue was seen to be limited by a fibrous capsule with morphological features consistent with atypical parathyroid adenoma. The mandibular tumour has receded and the patient declined further procedures. This is the first case reported of brown tumour as the primary manifestation of an atypical parathyroid adenoma, a lesion that shares some features with parathyroid carcinoma without the unequivocal properties of malignancy.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
5/53. Intralesional corticosteroid injection for treatment of central giant-cell granuloma.BACKGROUND: The central giant cell granuloma, or CGCG, is a benign intraosseous lesion of the jaw. It is found predominantly in children and young adults. It is an asymptomatic lesion, which often becomes evident on routine radiographic examination. Giant cell lesions have been described as both nonaggressive and aggressive in nature, with recurrence noted in cases of aggressive lesions. Central giant cell lesions present as unilocular or multilocular radiolucent defects on radiographs. Multinucleated giant cells within a collagenous stroma are the characteristic histopathologic feature of CGCG. CASE DESCRIPTION: The authors describe a 10-year-old girl with an expansile lesion of the mandible. The panoramic radiograph showed a well-circumscribed mixed radiolucent-radiopaque lesion of the left mandibular body. An incisional biopsy of the lesion was performed to establish a histologic diagnosis. The specimen was submitted for frozen-section examination, and a diagnosis of CGCG was made. serum calcium, parathyroid hormone and phosphorous levels were normal. The patient was treated successfully with intralesional corticosteroid injections. CLINICAL IMPLICATIONS: Central giant cell lesions have been treated surgically with aggressive curettage. More aggressive and recurrent lesions require resection, which leads to major defects of the jaws. This form of surgical treatment can be particularly disfiguring for a child or young adult. An alternative nonsurgical approach is the intralesional administration of corticosteroids, which have been effective in the treatment of CGCG. If a dentist suspects a patient may have CGCG, he or she should refer the patient to an oral surgeon for follow-up.- - - - - - - - - - ranking = 1.6keywords = giant (Clic here for more details about this article) |
6/53. Foreign-body granuloma occurring in the mandible subsequent to orthognathic surgery: a case report.We report the first case of foreign-body granuloma occurring in the mandible of a patient with a history of orthognathic surgery. A 20-year-old male patient had a hard swelling and pain in the left mandibular angle and the parotid area. Plain radiographs showed a radiolucent lesion extending from the buccal area under the left sigmoid notch of the mandible to the mandibular angle. Computed tomographs showed an expanded osteolytic mass in the same area, with destruction of most of the bone on the buccal side. A microscopic examination revealed filamentous foreign material associated with chronic inflammatory cell infiltration and an aggregation of multinucleated giant cells. Foreign-body granuloma in the mandible, although rare, should be included in the differential diagnosis in cases of postoperative masses.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
7/53. Experience with anti-angiogenic therapy of giant cell granuloma of the facial bones.Interferon alfa-2a inhibits angiogenesis and was discovered through a series of laboratory experiments that began in 1980. It was first used in 1989 in the management of a child with pulmonary haemangiomatosis. Interferon alfa A was then subsequently use to treat life threatening haemangiomas and other vascular tumours in various organs. Kaban reported on anti-angiogenic therapy of a recurrent giant cell tumour of the mandible in a 5 year old girl with interferon alfa-2a reasoning that as it was a rapidly proliferating vascular lesion it could be treated as an haemangioma. This paper reviews the history and role of interferon alfa-2a as an angiogenesis inhibitor in the treatment of complex haemangiomas and presents its use in the successful management of a rapidly growing central giant cell granuloma in a 4 year old boy in australia.- - - - - - - - - - ranking = 1.2keywords = giant (Clic here for more details about this article) |
8/53. Central giant cell granuloma.The central giant cell granuloma (CGCG) is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in tooth-bearing areas. Its etiology is unknown and its biological behavior is poorly understood. This condition is a slow-growing, asymptomatic lesion that usually affects children and young adults, predominantly females. The following report illustrates the differential diagnosis, surgery, final diagnosis and pathology of a fast-growing CGCG in a 4-year-old girl.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
9/53. cherubism in siblings: a case report.cherubism is a non-neoplastic bone disease characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a cherubic appearance. cherubism may appear in solitary cases or in many members of the same family, often in multiple generations. On radiography, the lesions exhibit bilateral multilocular radiolucent areas. Histopathologic evaluation reveals proliferating fibrous connective tissue containing numerous multinucleated giant cells. Since the first description of this condition in 1933, almost 200 cases have been reported. We describe cherubism in 2 siblings and briefly review the literature on this subject.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
10/53. oral manifestations of renal osteodystrophy: case report and review of the literature.renal osteodystrophy, characterized by uneven bone growth and demineralization, is described. oral manifestations of the disorder are described, and the value of dental radiographs in early detection of renal osteodystrophy is noted. A case report of a patient with severe oral complications, which resulted from long-standing end-stage renal disease and secondary hyperparathyroidism, is presented. Giant cell lesions of hyperparathyroidism, referred to as brown tumors (which may be associated with pain and swelling), are the key clinical oral manifestations and are the most dramatic dental radiographic finding in patients with renal osteodystrophy. Bone changes may include loss of lamina dura, giant cell lesions of hyperparathyroidism, and bone demineralization. The dentist's role in detection, assessment, and treatment is stressed.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
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