1/3. Simultaneous bilateral occurrence of a mixed mesodermal tumor and cystadenocarcinoma in the ovary.The mixed mesodermal tumor is a very uncommon malignancy. The aggressiveness of this lesion is illustrated by extremely poor prospects for afflicted patients: postoperative survival is usually shorter than 24 months. According to the literature, malignant mixed tumor of the ovary is rather rare and its occurrence with other malignancy is exceptional. We report here a case of a 62-years old woman with serous cystadenocarcinoma in the right ovary and a heterologous malignant mixed mesodermal tumor in the left one. Both tumors expressed cytokeratins, while only the mesodermal tumor expressed S-100 and focal NSE.- - - - - - - - - - ranking = 1keywords = cystadenocarcinoma (Clic here for more details about this article) |
2/3. Histological evaluation of mixed mesodermal tumor of the ovary.Mixed mesodermal tumor (MMT) arising from the ovary is very rare, but we recently encountered two cases of this tumor. The tumors were examined histologically using hematoxylin-eosin, alcian blue, periodic acid-Schiff (PAS), and toluidine blue staining, as well as immunohistochemical staining for S-100 protein. The two patients were postmenopausal women aged 68 and 58 years, respectively. The carcinomatous region of the mixed tumor was endometrioid carcinoma in Patient 1 and serous cystadenocarcinoma in Patient 2, while the sarcomatous region was chondrosarcoma in both patients. The chondrosarcoma tissue was positive for PAS, alcian blue, toluidine blue, and S-100 protein.- - - - - - - - - - ranking = 0.2keywords = cystadenocarcinoma (Clic here for more details about this article) |
3/3. Mixed mesodermal tumor of the ovary: immunohistochemical study with histogenetic consideration.The clinical, histological and immunohistochemical features of three cases of ovarian mixed mesodermal tumor (MMT) were examined. The epithelial component was serous papillary cystadenocarcinoma in case 1 and 3, and endometrioid adenocarcinoma in case 2. In case 1, undifferentiated adenocarcinoma was also seen. The mesenchymal component was fibrosarcomatous and chondrosarcomatous in case 1 and 2. In case 3, only fibrosarcomatous area was seen. No endometriosis was observed. Immunohistochemically, the epithelial component showed positivity for epithelial membrane antigen in all three cases. S-100 protein was positive in two cases with chondrosarcomatous differentiation. The fibrosarcomatous area showed positivity for vimentin in all three cases. However desmin, myosin and myoglobin were negative. The antibodies thought to be epithelial or mesenchymal markers unexpectedly reacted positively in some cells; for example, EMA was positive in fibrosarcomatous and chondrosarcomatous cells. Therefore, it was speculated that because the undifferentiated tumor cells had a biphasic character, MMT might originate from immature multipotential cells of surface epithelium and subcapsular connective tissue of the ovary.- - - - - - - - - - ranking = 0.2keywords = cystadenocarcinoma (Clic here for more details about this article) |