1/105. Resolution of disseminated molluscum contagiosum with Highly Active Anti-Retroviral Therapy (HAART) in patients with AIDS. molluscum contagiosum (MC), a cutaneous infection caused by a dna virus belonging to the poxvirus group, affects about 5-10% of patients with HIV disease, often showing extensive, severe lesions, unresponsive to therapy [1]. During the follow-up of three patients with AIDS for MC recalcitrant to therapy, we noted their cutaneous lesions cleared 5-6 months after they had begun Highly Active Anti-Retroviral Therapy (HAART). This therapy includes an hiv protease inhibitor (indinavir) and two reverse transcriptase inhibitors [2, 3]. ( info) |
2/105. Pleomorphic T-cell infiltrate associated with molluscum contagiosum. The authors observed a pleomorphic lymphocytic infiltrate composed of CD8 cytotoxic/suppressor T-cells in two pediatric cases associated with molluscum contagiosum. T-cell clonality was not detected. In both cases, the lesions resolved after the biopsy was performed. The patients were otherwise healthy, and no evidence of lymphoproliferative process was detected on follow-up. The authors believe the pleomorphic lymphoid infiltrate is inflammatory and reactive in nature. The close apposition of lymphocytes to molluscum bodies and cytoid bodies with high expression of CD30 and the proliferating marker Ki67 is suggestive of a cytotoxic cell-mediate blastic reaction against poxvirus antigens. ( info) |
3/105. Interferon alpha treatment of molluscum contagiosum in immunodeficiency. A sister (aged 6 years) and brother (aged 8 years) presented four months apart with severe molluscum contagiosum. Both children demonstrated clinical and laboratory evidence of combined immunodeficiency. The extent of skin involvement by molluscum contagiosum precluded conventional treatment as well as intralesional interferon alpha (IFN alpha). Both subjects responded well to subcutaneous IFN alpha. ( info) |
| molluscum contagiosum spread by sexual contact may be mistaken for other venereal diseases. The occurrence of a penile lesion resembling herpes progenitalis, and successful therapy of genital mollusca with topical tretinoin (vitamin a acid) is described. ( info) |
5/105. molluscum contagiosum. A case report with fine needle aspiration cytologic diagnosis and ultrastructural features. BACKGROUND: Cytomorphologic and ultrastructural features of molluscum contagiosum, a rare skin lesion of viral etiology, are presented. CASE: A 4-month-old female was referred for fine needle aspiration cytology of papules over the back and chest wall. A Giemsa-stained preparation of whitish material aspirated from the chest wall nodule showed numerous large, intracytoplasmic, basophilic bodies that pushed the host cell nucleus to the periphery, giving a signet-ring appearance to a few cells. A cytologic diagnosis of molluscum contagiosum was suggested. On electron microscopy numerous intracytoplasmic viral particles were demonstrated, thus confirming the cytologic diagnosis. CONCLUSION: In clinically unsuspected cases, the cytologic diagnosis of molluscum contagiosum can be suggested by demonstrating pathognomonic molluscum bodies in aspirated material. ( info) |
| molluscum contagiosum (MC) is a self-limiting viral disease of the skin and the mucous membranes. Facial and perioral MC is seen with increasing frequency in human immunodeficiency (HIV) infection, particularly in HIV infected homosexual men. The purpose of this study was to describe clinical observations of facial and perioral MC in HIV infected patients. One hundred and eighty HIV-positive individuals (160 males and 20 females) were examined over a period of five years. Fifty-eight were homosexual men and 19 were bisexual men. Fifty-one of 180 patients at the time of the first examination had CD 4 count < 200 cells/mm3 and another 63 presented loss of CD 4 cells in this level, during this period. Three HIV infected patients (two homosexual and one bisexual) were affected with facial and perioral MC. At the time of MC diagnosis the CD 4 count was less than 200 cells/mm3 for all three patients. One patient died nine months after MC diagnosis and the other two are still alive. It is remarkable that in this study no clinical lesions were observed on other sites of the skin. ( info) |
7/105. Recalcitrant molluscum contagiosum in an HIV-afflicted male treated successfully with topical imiquimod. molluscum contagiosum is a common cutaneous infection complicating the course of patients afflicted with acquired immunodeficiency syndrome. We describe a human immunodeficiency virus-positive patient with a disfiguring molluscum contagiosum infection of the face. Conventional cytodestructive therapies failed in this patient, but imiquimod 5% cream, an immunomodulator, clinically cleared his cutaneous disease. ( info) |
8/105. The surgical treatment of molluscum contagiosum in a pediatric AIDS patient. molluscum contagiosum (MC) has arisen as an opportunistic pathogen in human immunodeficiency virus (HIV) disease. Recent reports have focused on the presentation of MC in adults who are HIV positive. The authors describe MC in a pediatric patient with acquired immmune deficiency syndrome. This particular patient showed the same atypical lesion morphology, distribution, and chronic course that is seen in the adult HIV patient. As in the adult patient, treatment in the pediatric patient also remains challenging, with limited success of traditional treatment modalities. The authors were able to achieve long-term remission and an excellent cosmetic result through meticulous superficial surgical excision of the patient's MC lesions. ( info) |
9/105. CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum. EMLA (eutectic mixture of local anesthetics) cream is used topically to provide local anesthesia for a variety of painful superficial procedures. Although the side effects of EMLA are usually mild and transient local skin reactions, potential life threatening complications can be encountered. We report a case of central nervous toxicity after EMLA application for curettage of molluscum contagiosum lesions in a pediatric patient. This complication was the result of a therapeutic misadventure that led to an excessive application of EMLA cream over an extensive area causing an overdose of lidocaine and prilocaine with their subsequent systemic toxicities. ( info) |
| Actinic granuloma of O'Brien and giant molluscum contagiosum in immunocompetent adults are rare skin disorders. There have been no previous reports of these two conditions occurring together. We report this occurrence in a 57-year-old Caucasian woman. ( info) |