1/6. Type-3 von willebrand's disease in a rhesus monkey (macaca mulatta).Severe type-3 von Willebrand's disease (vWD) was diagnosed in a young male rhesus monkey that had excessive bleeding from minor wounds. plasma samples from the monkey had no detectable quantitative or functional von willebrand factor (vWF), low Factor-VIII coagulant activity, and moderate prolongation of activated partial thromboplastin time. Testing of the affected monkey's extended family revealed a likely hereditary basis for the vWD, in that the sire and a paternal half-sister had markedly reduced plasma vWF concentration. Fresh whole blood was transfused to control frequent bleeding episodes throughout the monkey's life. Although vWD is the most common inherited bleeding disorder in humans and dogs, this is the first report of vWD in a nonhuman primate.- - - - - - - - - - ranking = 1keywords = rhesus (Clic here for more details about this article) |
2/6. Ampullary carcinoma in a group of aged rhesus macaques (macaca mulatta).Ampullary carcinoma was diagnosed in 6 rhesus macaques that ranged in age from 20 to 35 years. Signalment, premonitory signs of disease, and results of clinical biochemical and hematologic analyses varied among animals. Histologically, the neoplastic cells obliterated the ampulla, with regional spread to the duodenum in all 6 animals and to the pancreas in one animal. Two animals had metastases to the lung, and another two had metastases to the pancreoduodenal lymph nodes and liver. One animal had mesocolonic metastasis. Malignant tumors of the ampullary region are rare in domestic animals, and account for less than 5% of all cancers of the digestive tract in humans.- - - - - - - - - - ranking = 1keywords = rhesus (Clic here for more details about this article) |
3/6. Oral papillomas and papilliform lesions in rhesus macaques (macaca mulatta).Oral papillomas in two male rhesus macaques that were diagnosed morphologically as filiform and squamous types are described. Two additional macaques had oral papilliform lesions consistent histologically with papillary hyperplasia. immunohistochemistry, along with electron microscopy and PCR assays, failed to demonstrate evidence of papillomavirus in any of the tumors; however, such results are often lacking when suspect oral lesions in humans and other species are assessed. Other potential causes of the papillary masses include chronic irritation and perhaps a genetic susceptibility. Benign tumors of the oral epithelium in macaques have not been reported previously; they appear to be rare and of variable clinical significance.- - - - - - - - - - ranking = 1keywords = rhesus (Clic here for more details about this article) |
4/6. amniotic band syndrome in a rhesus monkey: a case report.A rhesus monkey fetus was examined by ultrasound at 110, 111, and 113 gestational days (GD) and showed features suggestive of amniotic band syndrome (ABS). These included an unusual craniofacial configuration, cortical distortion, asymmetrical hydrocephalus, a right occipital porencephalic cyst, and hydropic membranes with several free strands attached to the fetal head, neck, and scapular regions. The fetus remained fixed in the same position with the head retroflexed during each consecutive exam. A hysterotomy was performed and ABS was confirmed.- - - - - - - - - - ranking = 1keywords = rhesus (Clic here for more details about this article) |
5/6. Villus atrophy and malabsorption in a rhesus monkey.Villus atrophy involving the proximal small intestine was diagnosed in a rhesus monkey (macaca mulatta) at necropsy. A juvenile, male, captive-born monkey exhibited weight loss, hypoalbuminemia, patchy alopecia, eosinophilia, and vomiting. D-xylose absorption was impaired. Contrast radiography revealed thickening of the gastric and intestinal walls, gaseous distension of intestines and a rapid transit rate. There was no clinicopathologic evidence of involvement of organs other than the gastrointestinal tract. The intestinal villus atrophy was similar in distribution and morphology to that of human celiac disease.- - - - - - - - - - ranking = 1keywords = rhesus (Clic here for more details about this article) |
6/6. dirofilaria immitis infection in a rhesus monkey (macaca mulatta).A spontaneously occurring dirofilaria immitis infection was diagnosed in a rhesus monkey at necropsy. A single immature worm was found in the right ventricle. Granulomatous eosinophilic arteritis was present within pulmonary arteries in the lung. No microfilariae were found.- - - - - - - - - - ranking = 1keywords = rhesus (Clic here for more details about this article) |