1/5. melanoma of the face and mouth in nigeria. A review and comment on three cases.The absolute incidence of melanoma at all sites in blacks is higher than is commonly credited. There is a shift in site incidence to less pigmented areas including the mucosae but oral melanoma is still rarely reported in Africans. An unusual case of facial melanoma arising in a childhood naevus, and two oral melanomas, all in Nigerians, are described. The salient clinical features and the treatment of these cases are discussed, and the possible relationship between pigmented patches and melanomas in the mouths of blacks is examined.- - - - - - - - - - ranking = 1keywords = naevus (Clic here for more details about this article) |
2/5. A novel mutation in the keratin 4 gene causing white sponge naevus.BACKGROUND: White sponge naevus (WSN) is a rare, autosomal dominant disorder that predominantly affects noncornified stratified squamous epithelia, most commonly the buccal mucosa. Clinically, WSN manifests as thickened spongy mucosa with a white opalescent tint in the mouth and may be confused with other disorders that cause white lesions on oral mucosa. Recent studies have identified pathogenic mutations in KRT4 and KRT13, the genes encoding mucosa-specific keratins, in WSN. OBJECTIVES: To search for possible mutations in KRT4 and KRT13. methods: We report a case of WSN in a young man who presented with diffuse irregular whitish plaques involving the buccal and gingival mucosae and the tongue. Results Pathologically, the affected mucosa showed epithelial thickening, parakeratosis and extensive vacuolization of the suprabasal keratinocytes. mutation analysis revealed a heterozygous missense mutation 1345G-->A in KRT4, predicting an amino acid change, E449K, in the 2B domain of the K4 polypeptide. CONCLUSIONS: We report the first mutation analysis of a Taiwanese patient with WSN. Potentially this novel mutation could disrupt the stability of keratin filaments and result in WSN.- - - - - - - - - - ranking = 5keywords = naevus (Clic here for more details about this article) |
3/5. White sponge naevus with minimal clinical and histological changes: report of three cases.White sponge naevus (WSN) is a rare autosomal dominant disorder that predominantly affects non-cornified stratified squamous epithelia: oral mucosa, oesophagus, anogenital area. It has been shown to be related to keratin defects, because of mutations in the genes encoding mucosal-specific keratins K4 and K13. We illustrate three cases diagnosed as WSN, following the clinical and histological criteria, with unusual appearance. They presented with minimal clinical and histological changes that could be misleading in the diagnosis. The patients showed diffuse irregular plaques with a range of presentations from white to rose coloured mucosae involving the entire oral cavity. In one case the lesion was also present in the vaginal area. The histological findings included epithelial thickening, parakeratosis and extensive vacuolization of the suprabasal keratinocytes, confirming WSN diagnosis. Clinical presentation and histopathology of WSN are discussed in relation to the differential diagnosis of other oral leukokeratoses.- - - - - - - - - - ranking = 5keywords = naevus (Clic here for more details about this article) |
4/5. Acquired pigmentation simulating peutz-jeghers syndrome: initial manifestation of diffuse uveal melanocytic proliferation.A 74-year-old man with an occult carcinoma of the colon developed pigmentation of the mouth and penis typical of the peutz-jeghers syndrome as the first manifestation of bilateral diffuse uveal melanocytic proliferation. The simultaneous appearance of extraocular pigmented lesion and those in the uveal tract of both eyes of this patient provides further evidence that bilateral diffuse uveal melanocytic proliferation may be caused by activation of occult melanocytic naevus cells in response to either a hormone-producing carcinoma or to some other common oncogenic stimulus.- - - - - - - - - - ranking = 1keywords = naevus (Clic here for more details about this article) |
5/5. An intraoral combined blue naevus.A combined blue naevus is described which lay below the epithelial surface of the attached lingual gingiva and the anterior region of the floor of the mouth. There was no visible pigmentation due to the masking effect of the overlying hyperkeratotic mucosa. Histologically the lesion was composed of a mixture of intramucosal naevus cells and dendritic melanocytes typical of a common blue naevus. Prophylactic excision of intraoral naevi is advised.- - - - - - - - - - ranking = 7keywords = naevus (Clic here for more details about this article) |