1/10. Verrucous carcinoma occurring in a lesion of oral lichen planus.Verrucous carcinoma of the oral cavity is relatively rare. Well-documented associations include human papillomavirus and carcinogens such as tobacco. Less well understood is the association with chronic inflammation, such as seen in lichen planus. Verrucous carcinoma has previously been described occurring in lesions of lichen planus of the foot and penis. We report the first case, to our knowledge, of verrucous carcinoma occurring in a lesion of oral lichen planus.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
2/10. Cancer of the oral cavity- a growing concern in the micronesia: a case report from the Marshall islands.Cancer of the oral cavity is of growing concern worldwide. In the micronesia, there has been a recent increase in use of betel nut and tobacco chewing in addition to already existing problem of smoking and alcohol drinking. These deleterious habits have further added the risk for development of oral cancers in the Marshall islands. The oral cancers have good prognosis, which is directly related to the early diagnosis and treatment. Advanced staged cancers need mutilating surgery in addition to radiotherapy and carry high mortality rate. The epidemiology, etiology and recent approaches in the management of oral cavity cancer has been discussed along with a case report of advanced cancer of the floor of the mouth from the Marshall islands.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
3/10. Detecting oral cancer: a new technique and case reports.The VELscope is an important aid in patient assessment, and when added to a well-thought out clinical assessment process that takes into consideration the age of the patient and risk factors that include tobacco, alcohol, and immunologic status, it increases the clinician's ability to detect oral changes that may represent premalignant or malignant cellular transformation. False positive findings are possible in the presence of highly inflamed lesions, and it is possible that use of the scope alone may result in failure to detect regions of dysplasia, but it has been our experience that use of the VELscope improves clinical decision making about the nature of oral lesions and aids in decisions to biopsy regions of concern. Where tissue changes are generalized or cover significant areas of the mouth, use of the scope has allowed us to identify the best region for biopsy. As with all clinical diagnostic activities, no single system or process is enough, and all clinicians are advised to use good clinical practice to assess patients and to recall and biopsy lesions that do not resolve within a predetermined time frame. Lesions that are VELscope-positive and absorb light need to be followed with particular caution, and if they do not resolve within a 2-week period, then further assessment and biopsy are generally advised. It is much better to occasionally sample tissue that turns out to be benign than to fail to diagnose dysplastic or malignant lesions. In our fight to protect patients from cancer, the VELscope improves our odds for early detection, hopefully resulting in fewer deaths from oral cancer.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
4/10. Smokeless tobacco addiction: a threat to the oral and systemic health of the child and adolescent.The use of smokeless tobacco (ST) within the united states has increased greatly in recent years, especially among adolescent boys and young men. Recent national data completed from several large scale studies indicate that 10-12 million Americans use some form of ST. Representing a significant systemic and oral health risk, ST usage can produce a wide range of negative effects on both soft and hard oral tissues. These oral conditions include bad breath, discolored teeth and restorative materials, excessive tooth surface wear (abrasion), decreased ability to taste and smell, gingival (gum) recession, advanced periodontal soft and hard tissue destruction, tooth loss, soft tissue erythema and leukoplakia. Long-term ST usage is directly correlated to an increased risk of cancer of the mouth, larynx, throat and esophagus. Much of the destruction of oral tissues is related to the localization of the tobacco quid; i.e., it is habitually held in only one spot in the mouth. nicotine from ST can activate the sympathetic nervous system thereby significantly increasing heart rate, blood pressure, cardiac stroke volume and output and coronary blood flow. A common misconception is that ST is a 'safe' alternative to smoking cigarettes. Several recent Surgeon General's Reports list ST as being addictive. It is highly possible that ST users will 'graduate' to cigarettes if they eventually conclude that these products are socially unacceptable, inconvenient or out of vogue. Health professionals, educators, parents and schoolchildren need to be informed about the significant health risks associated with ST use.- - - - - - - - - - ranking = 6keywords = tobacco (Clic here for more details about this article) |
5/10. Mouthwash and oral cancer: carcinogen or coincidence?Among 200 patients with squamous cell cancer of the head and neck, 11 persons abstained from all alcoholic beverages and tobacco. All but one of these 11 patients had used mouthwash many times daily for more than 20 years. Most of them used a brand of mouthwash that contained 25% alcohol. This evidence, along with information from other patients, may be used to confirm or refute the theory that mouthwash may be carcinogenic for susceptible persons.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
6/10. Oral squamous cell carcinoma in identical twins: report of a case.This case report describes two middle-aged identical female twins with a mild to moderate history of tobacco and alcohol abuse who developed squamous cell carcinomas in the same anatomic sites. By exclusion of major factors, a correlation between heredity and the incidence of cancer in these cases appears likely; however, carcinogenic agents (tobacco and alcohol) must also be considered as contributing factors. Close observation of siblings (and certainly twins) is recommended when head and neck carcinoma occurs prior to middle age. Although no genetic population prone to oral cancer is known, the disease is rare enough in younger individuals to raise the question of a possible genetic predisposition.- - - - - - - - - - ranking = 2keywords = tobacco (Clic here for more details about this article) |
7/10. Four primary malignant neoplasms in a single patient.A 60-year-old Caucasian male, with a previous history of a 10-year occupational exposure to ionizing radiation, chemical carcinogens, and a long history of tobacco and alcohol abuse, developed synchronous squamous cell carcinoma of the floor of the mouth and adenocarcinoma of the lung. Four years later, squamous cell carcinoma of the larynx followed by squamous cell carcinoma of the tongue were diagnosed. In this case report, we suggest that increased exposure to multiple carcinogenic factors may result in an increased incidence of both synchronous and metachronous primary malignant neoplasms.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
8/10. Oral verrucous carcinoma: report of two cases and review of literature.Verrucous carcinoma is a rare and distinct pathological and clinical variant of well-differentiated squamous cell carcinoma. Two case reports of histologically proven oral verrucous carcinoma are presented. One case presented with a history of tobacco chewing, snuff taking and miraa chewing. While the relationship between tobacco chewing or snuff dipping and verrucous carcinoma has been investigated and described, the role played by miraa chewing is still unknown and thus requires further study. Both cases were successfully managed by only conservative surgical excision. No radiotherapy was used. Clinical and histo-pathological examination of verrucous carcinoma is therefore very important in its diagnosis and treatment planning.- - - - - - - - - - ranking = 2keywords = tobacco (Clic here for more details about this article) |
9/10. Concurrent verrucous carcinomas of the lip and buccal mucosa.Florid oral papillomatosis presents a picture of multiple squamous papillary lesions found in the oral pharynx. Multiple risk factors associated with the development of these lesions include possible association with papilloma virus, the use of tobacco products, and chronic inflammation or irritation such as that caused by poorly fitted dentures. The major risk factor of these benign squamous lesions is the dedifferentiation into a well-differentiated verrucous carcinoma. However, treatment in the early stage of the disease is usually successful. Surgical excision has been favored as the initial approach. The use of radiotherapy for verrucous carcinoma is controversial. In numerous reported cases dedifferentiation of the tumor has produced an anaplastic squamous cell carcinoma. More recent articles, however, indicate that the risk for dedifferentiation of verrucous carcinoma due to radiotherapy may be overstated.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
10/10. Is oral cancer susceptibility inherited? Report of five oral cancer families.All the oral cancer patients registered at the Regional Cancer Centre, Trivandrum, during January to July 1995 were subjected to detailed pedigree analysis. This revealed that oral cancer tends to aggregate in families. Like other familial cancers, a family history of oral cancer was associated mostly with an early age of onset of the disease. family members without habits such as tobacco chewing, smoking or alcohol consumption were also affected. These observations prompt us to suggest the probable inheritance of an oral cancer susceptibility gene in these families. The familial aggregation, mostly site-specific, with an autosomal dominant mode of inheritance, was observed in 0.94% of the total oral cancers. This necessitates the need to undertake studies to elucidate the molecular lesions responsible for oral cancer susceptibility in families.- - - - - - - - - - ranking = 1keywords = tobacco (Clic here for more details about this article) |
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