Cases reported "Myoclonus"

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1/7. myokymia and facial contraction in multiple sclerosis.

    Continuous unilateral facial myokymia and facial contraction occurred in a patient with multiple sclerosis and there was subsequent resolution of these abnormalities. I compare abnormal facial movements of this type with those caused by other neurological diseases and discuss the possible mechanism of myokymia in diseases of the central and peripheral nervous systems.
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ranking = 1
keywords = myokymia
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2/7. Facial myokymia and brain stem tumor.

    An autoptic case of facial myokymia in glioma of the pons is described. The facial myokymia was the only symptom for many years. The authors emphasize the importance of the facial myokymia as a precocious sign of pons tumor and stress the meaning of the EMG in the differential diagnosis between facial myokymia in brain stem tumor and facial hyperkinesa in other diseases.
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ranking = 4
keywords = myokymia
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3/7. myokymia and impaired muscular relaxation with continuous motor unit activity.

    We have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhydrosis during their illness. myokymia was present over the entire body in both. On repetitive testing of muscle strength each patient showed initial fatigue followed by increasing strength as he continued his efforts. Both patinets improved on phenytoin therapy at high blood levels. Nerve conduction velocities were decreased. Electromyograms showed continuous electrical activity at rest which persisted during sleep and spinal anaesthesia but was diminished by curare. Intravital staining with methylene blue in one case demonstrated sprouting and beading of motor nerve terminals with multiple innervation of muscle fibres. The neurophysiological and pathological findings in these two cases indicate an abnormality of peripheral nerve in this disorder.
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ranking = 0.5
keywords = myokymia
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4/7. myokymia, muscle hypertrophy and percussion "myotonia" in chronic recurrent polyneuropathy.

    Three unusual features were observed in a patient with chronic relapsing polyneuropathy: myokymia, muscle hypertrophy, and prolonged contraction in response to muscle percussion. Low nerve conduction velocity and conduction block were demonstrated in all motor nerves tested, indicating a demyelinating peripheral neuropathy. myokymia was caused by spontaneous motor unit activity which was shown to originate in peripheral nerves, since it persisted after nerve block and was abolished by regional curarization. Muscle hypertrophy was attributed to increased peripheral nerve activity, and the prolonged contraction of muscle in response to direct percussion was attributed to irritability of intramuscular nerve terminals.
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keywords = myokymia
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5/7. calcium effect on generation and amplification of myokymic discharges.

    Maneuvers designed to manipulate ionized calcium (Ca ) were carried out in two patients with inflammatory polyradiculoneuropathy and myokymia. Increased clinical myokymia and myokymic burst amplification occurred when ionized Ca was lowered by plasma exchange or hyperventilation. Increasing ionized Ca (by intravenous infusion of CaCl2) decreased the myokymia. These findings indicate that myokymic discharges are altered by changes in serum ionized Ca and effects on axonal excitability.
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ranking = 1.5
keywords = myokymia
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6/7. Superior oblique myokymia. A possible etiologic factor.

    Two cases of superior oblique myokymia developed following superior oblique palsy. In some cases the condition may be due to abnormal discharges from the affected trochlear nucleus.
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ranking = 2.5
keywords = myokymia
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7/7. Localized myokymia caused by peripheral nerve injury.

    One year after a gunshot wound in the popliteal fossa, a 30-year-old man began to experience cramps and myokymia in the left gastrocnemius muscle. myokymia was characterized by vermicular fibrillary movements localized to the gastrocnemius muscle and accompanied by plantarflexion and dorsiflexion of the toes. neurologic examination, nerve conduction velocities, electromyograms, and muscle biopsy findings showed affection of left common peroneal and posterior tibial nerves. The myokymia disappeared during sleep, spinal anesthesia, and treatment with carbamazepine.
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ranking = 3
keywords = myokymia
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